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Food XenomiRNA Arise: MicroRNA Storm and Space
MicroRNAs (miRNAs) are mobile and protein noncoding genes. Therefore, miRNA genes are informational. RNA informational genes (Rigs) can regulate most...
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Systematic integration of molecular and clinical approaches in HCV-induced hepatocellular carcinoma
BackgroundMicroRNAs (miRNAs) play a crucial role in gene expression and regulation, with dysregulation of miRNA function linked to various diseases,...
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Functionalized siRNA-chitosan nanoformulations promote triple-negative breast cancer cell death via blocking the miRNA-21/AKT/ERK signaling axis: in-silico and in vitro studies
Oncogenic microRNA (miRNA), especially miRNA-21 upregulation in triple-negative breast cancer (TNBC), suggests a new class of therapeutic targets. In...
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Tumoral periprostatic adipose tissue exovesicles-derived miR-20a-5p regulates prostate cancer cell proliferation and inflammation through the RORA gene
BackgroundFrom the first steps of prostate cancer (PCa) initiation, tumours are in contact with the most-proximal adipose tissue called periprostatic...
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miR-9-5p is Downregulated in Serum Extracellular Vesicles of Patients Treated with Biperiden After Traumatic Brain Injury
Traumatic brain injury (TBI) is a prevalent and debilitating condition, which often leads to the development of post-traumatic epilepsy (PTE), a...
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Identification of exosomal microRNA panel as diagnostic and prognostic biomarker for small cell lung cancer
BackgroundSmall cell lung cancer (SCLC) has an exceptionally poor prognosis; as most of the cases are initially diagnosed as extensive disease with...
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Expression Signature of Immune-Related MicroRNAs in Autoimmune Skin Disease: Psoriasis and Vitiligo Insights
BackgroundPsoriasis and vitiligo are both chronic, skin-specific diseases classified as autoimmune diseases due to the involvement of several...
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Exonized Alu repeats in the 3’UTR of a CYP20A1_Alu-LT transcript act as a miRNA sponge
ObjectiveAlu repeats have gained huge importance in the creation and modification of regulatory networks. We previously reported a unique isoform of...
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The siRNA-mediated knockdown of AP-1 restores the function of the pulmonary artery and the right ventricle by reducing perivascular and interstitial fibrosis and key molecular players in cardiopulmonary disease
BackgroundPulmonary hypertension (PH) is a complex multifactorial vascular pathology characterized by an increased pulmonary arterial pressure,...
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Curcumin piperidone derivatives induce caspase-dependent apoptosis and suppress miRNA-21 expression in LN-18 human glioblastoma cells
BackgroundPreviously, we have reported on the two curcuminoid analogues with piperidone derivatives, namely FLDP-5 and FLDP-8 have more potent...
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Identification of Peripheral Blood miRNA Biomarkers in First-Episode Drug-Free Schizophrenia Patients Using Bioinformatics Strategy
Schizophrenia (SCZ) is a polygenic, complex mental disorder of which a diagnosis is often made based on psychiatric history and clinical observation...
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MiRNA/mRNA network topology in hepatitis virus B-related liver cirrhosis reveals miR-20a-5p/340-5p as hubs initiating fibrosis
BackgroundThe pathophysiology of hepatitis B-related liver cirrhosis (HBV-LC) remains unclear. This study aimed to explore the disease mechanisms...
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miRNA Therapy in Laboratory Models of Acute Spinal Cord Injury in Rodents: A Meta-analysis
miRNA therapy is popularly investigated in treating acute spinal cord injury (SCI) and offers a significant prospect for the treatment of acute SCI....
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Uncovering essential anesthetics-induced exosomal miRNAs related to hepatocellular carcinoma progression: a bioinformatic investigation
BackgroundAnesthetic drugs may alter exosomal microRNA (miRNA) contents and mediate cancer progression and tumor microenvironment remodeling. Our...
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MiRNA expression deregulation correlates with the Oncotype DX® DCIS score
BackgroundCurrent clinical criteria do not discriminate well between women who will or those who will not develop ipsilateral invasive breast cancer...
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Construction of CeRNA regulatory network based on WGCNA reveals diagnosis biomarkers for colorectal cancer
BackgroundColorectal cancer is the third most common cause of death among cancers in the world. Although improvements in various treatments have...
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Investigating genomic, proteomic, and post-transcriptional regulation profiles in colorectal cancer: a comparative study between primary tumors and associated metastases
IntroductionApproximately 50% of patients with primary colorectal carcinoma develop liver metastases. This study investigates the possible molecular...
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Bioinformatic Analysis of the Significance of the KIR2DL4 Gene in Recurrent Implantation Failure
Related studies have pointed out that Killer immunoglobulin-like receptor 2DL4 (KIR2DL4) was associated with vascular remodeling in early pregnancy,...
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Light-intensity exercise improves memory dysfunction with the restoration of hippocampal MCT2 and miRNAs in type 2 diabetic mice
Cognitive decline associated with type 2 diabetes mellitus (T2DM) is a risk factor to impair human health. Although light-intensity exercise prevents...
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A blood-based noninvasive miRNA signature for predicting survival outcomes in patients with intrahepatic cholangiocarcinoma
BackgroundThe prognosis in patients with intrahepatic cholangiocarcinoma (ICC) is generally poor. To improve treatment selection, we sought to...
