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Programmed Evolution by miRNA Memory
Diseases are deeply implicated in the aberrant expression of microRNA (miRNA) genes. The RNA Wave 2000 dogma consists of four criteria, as first...
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Systems genetics identifies miRNA-mediated regulation of host response in COVID-19
BackgroundIndividuals infected with SARS-CoV-2 vary greatly in their disease severity, ranging from asymptomatic infection to severe disease. The...
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Phenome-wide association study on miRNA-related sequence variants: the UK Biobank
BackgroundGenetic variants in the coding region could directly affect the structure and expression levels of genes and proteins. However, the...
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Identification and bioinformatic characterization of a serum miRNA signature for early detection of laryngeal squamous cell carcinoma
BackgroundThe growing understanding of cancer biology and the establishment of new treatment modalities has not yielded the expected results in terms...
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Machine Learning Using Gene-Sets to Infer miRNA Function
miRNA are regulators of cell phenotype, and there is clear evidence that these small posttranscriptional modifiers of gene expression are involved in...
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A miRNA screening identifies miR-192-5p as associated with response to azacitidine and lenalidomide therapy in myelodysplastic syndromes
BackgroundmiRNAs are small non-coding RNAs that regulate gene expression and are linked to cancer development and progression. miRNA profiles are...
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Identification of Metabolic Syndrome-Related miRNA–mRNA Regulatory Networks and Key Genes Based on Bioinformatics Analysis
Metabolic syndrome, which affects approximately one-quarter of the world’s population, is a combination of multiple traits and is associated with...
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miRkit: R framework analyzing miRNA PCR array data
ObjectiveThe characterization of microRNAs (miRNA) in recent years is an important advance in the field of gene regulation. To this end, several...
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A modified protocol for successful miRNA profiling in human precision-cut lung slices (PCLS)
ObjectiveHuman precision cut lung slices (PCLS) are widely used as an ex vivo model system for drug discovery and development of new therapies. PCLS...
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Genetic regulation and variation of expression of miRNA and mRNA transcripts in fetal muscle tissue in the context of sex, dam and variable fetal weight
BackgroundImpaired skeletal muscle growth in utero can result in reduced birth weight and pathogenesis of intrauterine growth restriction. Fetal and...
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microRNA Isolation, Expression Profiling, and Target Identification for Neuroprotection in Alzheimer’s Disease
Millions of people throughout the world are affected by neurodegenerative disorders like Alzheimer’s disease (AD), making them a major public health...
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Roles of miRNA dysregulation in the pathogenesis of multiple myeloma
Multiple myeloma (MM) is a malignant disease of plasma cells with complex pathology, causing significant morbidity due to its end-organ destruction....
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Identification of miRNA-Target Gene Pairs in the Parietal and Frontal Lobes of the Brain in Patients with Alzheimer’s Disease Using Bioinformatic Analyses
Alzheimer’s disease (AD) is a growing health concern worldwide. MicroRNAs (miRNAs) have been extensively studied in many diseases, including AD. To...
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MicroRNAs signatures, bioinformatics analysis of miRNAs, miRNA mimics and antagonists, and miRNA therapeutics in osteosarcoma
MicroRNAs (miRNAs) involved in key signaling pathways and aggressive phenotypes of osteosarcoma (OS) was discussed, including PI3K/AKT/MTOR, MTOR AND...
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The molecular and gene/miRNA expression profiles of radioiodine resistant papillary thyroid cancer
BackgroundPapillary thyroid cancer (PTC) is the most frequent endocrine tumor. Radioiodine (RAI) treatment is highly effective in these tumors, but...
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Inflammatory gene silencing in activated monocytes by a cholesterol tagged-miRNA/siRNA: a novel approach to ameliorate diabetes induced inflammation
There is a major unmet need for the development of effective therapies for diabetes induced inflammation. Increased adenosine-uridine rich elements...
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Analysis of lncRNA-miRNA-mRNA expression pattern in heart tissue after total body radiation in a mouse model
BackgroundRadiation therapy is integral to effective thoracic cancer treatments, but its application is limited by sensitivity of critical organs...
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miRNA Profile and Bioinformatic Analysis for Diagnosis in Patients with Stage IIIA Colon Cancer
Early diagnosis is a critical factor in deciding the outcome of colon cancer, as is the case with other types of cancers. Recent scientific...
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MiR-574-5P, miR-1827, and miR-4429 as Potential Biomarkers for Schizophrenia
Schizophrenia is a severe chronic debilitating disorder with millions of affected individuals. Diagnosis is based on clinical presentations, which...
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Profiling Host MicroRNA Responses to Henipavirus Infection
Diseases caused by henipaviruses feature incubation periods of up to 16 days, during which infected animals may show no apparent signs of disease yet...