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Engineered exosomes loaded with miR-449a selectively inhibit the growth of homologous non-small cell lung cancer
As an efficient drug carrier, exosome has been widely used in the delivery of genetic drugs, chemotherapeutic drugs, and anti-inflammatory drugs. As...
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TGF-β-induced CD4+ FoxP3+ regulatory T cell-derived extracellular vesicles modulate Notch1 signaling through miR-449a and prevent collagen-induced arthritis in a murine model
CD4 + FOXP3 + Treg cells are central to the maintenance of self-tolerance and can be defective in autoimmunity. In autoimmune rheumatic diseases,...
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RETRACTED ARTICLE: Tripterine ameliorates monosodium urate crystal-induced gouty arthritis by altering macrophage polarization via the miR-449a/NLRP3 axis
ObjectiveTripterine (Trip) is frequently applied to alleviate inflammation in various diseases such as rheumatoid arthritis. Macrophages have both...
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LncRNA SNHG7 sponges miR-449a to promote pituitary adenomas progression
This study aimed to characterize the expression status and potentially mechanistic involvement of SNHG7 in pituitary adenoma. Relative expression of...
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CDK13 upregulation-induced formation of the positive feedback loop among circCDK13, miR-212-5p/miR-449a and E2F5 contributes to prostate carcinogenesis
BackgroundBoth E2F transcription factor and cyclin-dependent kinases (CDKs), which increase or decrease E2F activity by phosphorylating E2F or its...
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MicroRNA-449a delays lung cancer development through inhibiting KDM3A/HIF-1α axis
BackgroundIt has been established that microRNA (miR)-449a is anti-tumorigenic in cancers, including lung cancer. Therefore, this study further...
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Expression and regulation of miR-449a and AREG in cerebral ischemic injury
Rodent focal ischemia models are widely used to mimic and examine human strokes. To the best of our knowledge, no investigation has systematically...
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ncRNAs-mediated high expression of TIMM8A correlates with poor prognosis and act as an oncogene in breast cancer
BackgroundBreast cancer is notorious for its increasing incidence for decades. Ascending evidence has demonstrated that translocase of inner...
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Transcriptome analysis reveals lung-specific miRNAs associated with impaired mucociliary clearance induced by cigarette smoke in an in vitro human airway tissue model
Exposure to cigarette smoke (CS) is strongly associated with impaired mucociliary clearance (MCC), which has been implicated in the pathogenesis of...
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MiR-449a-5p mediates mitochondrial dysfunction and phenotypic transition by targeting Myc in pulmonary arterial smooth muscle cells
AbstractMicroRNAs have been considered to participate in pulmonary arterial hypertension (PAH) and regulate numerous disease pathways in pulmonary...
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Circulating microRNAs as promising testicular translatable safety biomarkers: current state and future perspectives
Drug-induced testicular injury (DITI) is one of the often-observed and challenging safety issues seen during drug development. Semen analysis and...
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Assessment of expression profile of microRNAs in multiple sclerosis patients treated with fingolimod
Fingolimod is an immunotherapeutic drug approved in certain countries as first-line therapy for relapsing–remitting multiple sclerosis (RRMS). The...
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Epigenetic Connections of the TRPA1 Ion Channel in Pain Transmission and Neurogenic Inflammation — a Therapeutic Perspective in Migraine?
Persistent reprogramming of epigenetic pattern leads to changes in gene expression observed in many neurological disorders. Transient receptor...
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Transcriptome profiling of microRNAs reveals potential mechanisms of manual therapy alleviating neuropathic pain through microRNA-547-3p-mediated Map4k4/NF-κb signaling pathway
BackgroundLocal neuroinflammation secondary to spinal nerve compression in lumbar disk herniation (LDH) is a key driver contributing to neuropathic...
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miRNA Dysregulation in Schizophrenia
Schizophrenia is a complex neuropsychiatric disorder that alters synapse activity as well as neural circuits. An intricate intracellular network of...
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The strict regulation of HIF-1α by non-coding RNAs: new insight towards proliferation, metastasis, and therapeutic resistance strategies
The hypoxic environment is prominently witnessed in most solid tumors and is associated with the promotion of cell proliferation,...
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miRNAs as potential diagnostic biomarkers and pharmacogenomic indicators in psychiatric disorders
The heterogeneity of psychiatric disorders and the lack of reliable biomarkers for prediction and treatments follow-up pose difficulties towards...
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m6A genotypes and prognostic signature for assessing the prognosis of patients with acute myeloid leukemia
BackgroundN6-methyladenosine (m6A) has been confirmed to function critically in acute myeloid leukemia (AML) progression. Hitherto, the subty** and...
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Osteoarthritis related epigenetic variations in miRNA expression and DNA methylation
Osteoarthritis (OA) is chronic arthritis characterized by articular cartilage degradation. However, a comprehensive regulatory network for OA-related...
