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Mammary tumors alter the fecal bacteriome and permit enteric bacterial translocation
BackgroundCancer patients experience gastrointestinal and behavioral symptoms, and are at increased risk of systemic infection and inflammation....
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Alterations in the mammary gland and tumor microenvironment of formerly obese mice
BackgroundObesity is a risk factor for breast cancer, and women with obesity that develop breast cancer have a worsened prognosis. Within the mammary...
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Loss of Brca1 and Trp53 in adult mouse mammary ductal epithelium results in development of hormone receptor-positive or hormone receptor-negative tumors, depending on inactivation of Rb family proteins
BackgroundBreast cancer is a heterogenous disease with several histological and molecular subtypes. Models that represent these subtypes are...
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Human basal-like breast cancer is represented by one of the two mammary tumor subtypes in dogs
BackgroundAbout 20% of breast cancers in humans are basal-like, a subtype that is often triple-negative and difficult to treat. An effective...
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Ketogenic diet does not promote triple-negative and luminal mammary tumor growth and metastasis in experimental mice
Ketogenic diets (KDs) can improve the well-being and quality of life of breast cancer patients. However, data on the effects of KDs on mammary tumors...
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ADAMTS18 deficiency associates extracellular matrix dysfunction with a higher risk of HER2-positive mammary tumorigenesis and metastasis
BackgroundHuman epidermal growth factor receptor 2 (HER2)-positive breast cancer accounts for about 20% of all breast cancer cases and is correlated...
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Alpha-6 integrin deletion delays the formation of Brca1/p53-deficient basal-like breast tumors by restricting luminal progenitor cell expansion
BackgroundThe aberrant amplification of mammary luminal progenitors is at the origin of basal-like breast cancers associated with BRCA1 mutations....
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SerpinB2 deficiency is associated with delayed mammary tumor development and decreased pro-tumorigenic macrophage polarization
The in vivo functions of SerpinB2 in tumor cells and tumor-associated macrophages (TAMs) during breast cancer development and metastasis remain...
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Fibroblast Isolation from Mammary Gland Tissue and Syngeneic Murine Breast Cancer Models
Cancer-associated fibroblasts (CAFs) are vital within the tumor ecosystem, regulating tumor growth, dissemination, and response to therapy through...
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ERCC6L facilitates the onset of mammary neoplasia and promotes the high malignance of breast cancer by accelerating the cell cycle
BackgroundBreast cancer (BC) is the leading cause of morbidity and the second leading cause of death among female malignant tumors. Although...
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Elevated expression of wildtype RhoC promotes ErbB2- and Pik3ca-induced mammary tumor formation
Copy number gains in genes coding for Rho activating exchange factors as well as losses affecting genes coding for RhoGAP proteins are common in...
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mTOR inhibition abrogates human mammary stem cells and early breast cancer progression markers
BackgroundMammary physiology is distinguished in containing adult stem/progenitor cells that are actively amending the breast tissue throughout the...
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TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity
The transcription factor TRPS1 is a context-dependent oncogene in breast cancer. In the mammary gland, TRPS1 activity is restricted to the luminal...
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Lactation-associated macrophages exist in murine mammary tissue and human milk
Macrophages are involved in immune defense, organogenesis and tissue homeostasis. Macrophages contribute to the different phases of mammary gland...
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Lineage plasticity enables low-ER luminal tumors to evolve and gain basal-like traits
Stratifying breast cancer into specific molecular or histologic subtypes aids in therapeutic decision-making and predicting outcomes; however, these...
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PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development
BackgroundParathyroid hormone-related protein (PTHrP) is required for embryonic breast development and has important functions during lactation, when...
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Clinicopathologic and genomic features of lobular like invasive mammary carcinoma: is it a distinct entity?
This study describes “lobular-like invasive mammary carcinomas” (LLIMCas), a group of low- to intermediate-grade invasive mammary carcinomas with...
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Breast metastatic tumors in lung can be substituted by lung-derived malignant cells transformed by alternative splicing H19 lncRNA
Metastasis accounts for most cancer-associated deaths; yet, this complex process remains poorly understood, particularly the relationship between...
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Multiple roles for Bcl-3 in mammary gland branching, stromal collagen invasion, involution and tumor pathology
BackgroundThe Bcl-3 protein is an atypical member of the inhibitor of -κB family that has dual roles as a transcriptional repressor and a coactivator...
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Extracellular Matrix Glycation and Crosslinking in Mammary Tumor Progression
Breast cancer progression is accompanied by profound extracellular matrix (ECM) remodeling. A greater abundance of aligned fibrillar collagen is...