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MLXIPL promotes the migration, invasion, and glycolysis of hepatocellular carcinoma cells by phosphorylation of mTOR
BackgroundHepatocellular carcinoma (HCC) is associated with a high occurrence, mortality, and poor prognosis. MLX interacting protein like (MLXIPL)...
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AMPK/mTOR/p70S6K axis prevents apoptosis of Porphyromonas gingivalis-infected gingival epithelial cells via BadSer136 phosphorylation
Epithelial disruption is the initiation of most infectious disease. Regulation of epithelium apoptosis may play a key role in balance the survival...
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FMOD Alleviates Depression-Like Behaviors by Targeting the PI3K/AKT/mTOR Signaling After Traumatic Brain Injury
Depression frequently occurs following traumatic brain injury (TBI). However, the role of Fibromodulin (FMOD) in TBI-related depression is not yet...
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Autophagy inhibition mediated by trillin promotes apoptosis in hepatocellular carcinoma cells via activation of mTOR/STAT3 signaling
Apoptosis and autophagy have been shown to act cooperatively and antagonistically in self-elimination process. On the one side, apoptosis and...
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Expression of mTOR in normal and pathological conditions
The mechanistic/mammalian target of rapamycin (mTOR), a protein discovered in 1991, integrates a complex pathway with a key role in maintaining...
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AdipoRon Ameliorates Synaptic Dysfunction and Inhibits tau Hyperphosphorylation through the AdipoR/AMPK/mTOR Pathway in T2DM Mice
There is growing evidence showing that adiponectin (APN) can improve Alzheimer’s disease(AD)-like pathological changes by improving insulin...
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MALT1 Protease Regulates T-Cell Immunity via the mTOR Pathway in Oral Lichen Planus
Oral lichen planus (OLP) is a T cell–mediated immune mucosal disease of unknown pathogenesis. Whether mucosa-associated lymphoid tissue lymphoma...
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Knockdown of SETD5 Inhibits Colorectal Cancer Cell Growth and Stemness by Regulating PI3K/AKT/mTOR Pathway
SET domain-containing 5 (SETD5), a member of protein lysine methyltransferase family, is expressed in multiple cancers, making it potential...
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Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop
The meniscus is vital for maintaining knee homeostasis and function. Meniscal calcification is one of the earliest radiological indicators of knee...
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PRKAA2, MTOR, and TFEB in the regulation of lysosomal damage response and autophagy
Lysosomes function as critical signaling hubs that govern essential enzyme complexes. LGALS proteins (LGALS3, LGALS8, and LGALS9) are integral to the...
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EV71 5’UTR interacts with 3D protein affecting replication through the AKT-mTOR pathway
BackgroundEV71 is one of the important pathogens of Hand-foot-and-mouth disease (HFMD), which causes serious neurological symptoms. Several studies...
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Interaction of lncRNAs with mTOR in colorectal cancer: a systematic review
Colorectal cancer (CRC) is the third most widespread cancer and the fourth leading lethal disease among different societies. It is thought that CRC...
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TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury
BackgroundNecroptosis of macrophages is a necessary element in reinforcing intrapulmonary inflammation during acute lung injury (ALI). However, the...
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PI3K/Akt/mTOR-immunoreactive neurons in the rat mediobasal hypothalamus during aging
The hypothalamus is the regulatory hub controlling homeostasis, reproduction, circadian rhythms and endocrine system. It is also involved in the...
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Targeting the PI3K/AKT/mTOR and RAF/MEK/ERK pathways for cancer therapy
The PI3K/AKT/mTOR and RAF/MEK/ERK pathways are commonly activated by mutations and chromosomal translocation in vital targets. The PI3K/AKT/mTOR...
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DENV-2 NS1 promotes AMPK-LKB1 interaction to activate AMPK/ERK/mTOR signaling pathway to induce autophagy
The global incidence of dengue fever has gradually increased in recent years, posing a serious threat to human health. In the absence of specific...
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Inhibiting Caveolin-1-Related Akt/mTOR Signaling Pathway Protects Against N-methyl-D-Aspartate Receptor Activation-Mediated Dysfunction of Blood–Brain Barrier in vitro
BackgroundThe aim of this study was to further explore the role of caveolin-1 (Cav-1) related Akt/mTOR signaling pathway in blood brain barrier (BBB)...
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Intravesical instillation-based mTOR-STAT3 dual targeting for bladder cancer treatment
BackgroundRecent intravesical administration of adenoviral vectors, either as a single injection or in combination with immune checkpoint inhibitors,...
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The PI3K-Akt-mTOR pathway mediates renal pericyte-myofibroblast transition by enhancing glycolysis through HKII
BackgroundPericyte-myofibroblast transition (PMT) has been confirmed to contribute to renal fibrosis in several kidney diseases, and transforming...
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SLITRK6 promotes the progression of lung adenocarcinoma by regulating PI3K/AKT/mTOR signaling and Warburg effect
To investigate the role of SLITRK6 in lung adenocarcinoma (LUAD) and the underlying mechanism in it, clinical tissues and tissue microarray of LUAD...
