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Enhancing therapeutic anti-cancer responses by combining immune checkpoint and tyrosine kinase inhibition
Over the past decade, immune checkpoint inhibitor (ICI) therapy has been established as the standard of care for many types of cancer, but the...
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Targeting protein phosphatases in cancer immunotherapy and autoimmune disorders
Protein phosphatases act as key regulators of multiple important cellular processes and are attractive therapeutic targets for various diseases....
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A CD22–Shp1 phosphatase axis controls integrin β7 display and B cell function in mucosal immunity
The integrin α 4 β 7 selectively regulates lymphocyte trafficking and adhesion in the gut and gut-associated lymphoid tissue (GALT). Here, we describe...
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Fas ligand intracellular signaling: does PSTPIP mediate T cell death?
Fas and Fas ligand (FasL)-induced cell death is critical for the appropriate regulation of immune responses, especially those mediated by T cells. In...
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PTEN in Immunity
The tumor suppressor PTEN (Phosphatase and Tensin homolog deleted on Chromosome 10) executes critical biological functions that limit cellular growth...
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Expression analysis of Carassius auratus-leukocyte-immune-type receptors (CaLITRs) during goldfish kidney macrophage development and in activated kidney leukocyte cultures
Carassius auratus leukocyte immune-type receptors (CaLITRs) were recently discovered immunoregulatory receptors in goldfish that have diverse...
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A novel subclonal rearrangement of the STRN3::PDGFRB gene in de novo acute myeloid leukemia with NPM1 mutation and its leukemogenic effects
Chromosome translocations in the 5q31-33 region are associated with a range of hematologic malignancies, some of which involve the platelet-derived...
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Cancer Pathways
Proliferation, differentiation, and survival of normal cells are regulated by interlinked pathways that transmit and integrate signals from growth...
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New small molecules in dermatology: for the autoimmunity, inflammation and beyond
Objective and designThe discovery of new inflammatory pathways and the mechanism of action of inflammatory, autoimmune, genetic, and neoplastic...
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Oncogenes
Oncogenes are one important type of cancer gene and act in a dominant mode. They were first discovered in cancer-causing viruses. Retroviral...
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Targeting Pim kinases in hematological cancers: molecular and clinical review
Decades of research has recognized a solid role for Pim kinases in lymphoproliferative disorders. Often up-regulated following JAK/STAT and tyrosine...
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TCR Signals Controlling Adaptive Immunity against Toxoplasma and Cancer
T cells play a crucial role in adaptive immunity by recognizing and eliminating foreign pathogens and abnormal cells such as cancer cells. T cell...
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Immunohistochemistry in the Diagnosis of Primary and Secondary Cancers
In everyday practice, pathologists often have to face the challenging task of labeling primary and secondary malignancies, sometimes on a small...
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B Cell Immunity: BCRs, Antibodies and Their Effector Functions
In this chapter, we will explain that B cells respond to antigen stimulation of their BCR with the production of antibodies. This is a key feature of...
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Role of C-Type Lectins in the Tumor Microenvironment
C-type lectin receptors (CLRs) represent a broad and diversified family of pattern recognition receptors (PRRs) that are mainly expressed on the...
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PD-1 receptor outside the main paradigm: tumour-intrinsic role and clinical implications for checkpoint blockade
Blocking the inhibitory receptor PD-1 on antitumour T lymphocytes is the main rationale underlying the clinical successes of cancer immunotherapies...
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Helicobacter pylori Virulence Factors, Pathogenicity, and Gastric Cancer
Gastric cancer is a common cancer with a high incidence and mortality rate worldwide. Unfortunately, early-stage gastric cancer is asymptomatic....
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Assessment of the FRET-based Teen sensor to monitor ERK activation changes preceding morphological defects in a RASopathy zebrafish model and phenotypic rescue by MEK inhibitor
BackgroundRASopathies are genetic syndromes affecting development and having variable cancer predisposition. These disorders are clinically related...
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[18F]FDG PET/CT Imaging in Cancer Treatment with Checkpoint Inhibitors
In the last decade, the development of new therapeutic agents modulating the activity of the immune system and boosting its response against cancer...