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LncRNA HCG11 Accelerates Atherosclerosis via Regulating the miR-224-3p/JAK1 Axis
Atherosclerosis (AS) is the typical cardiovascular disease, which is the main underlying inducement of cardiovascular diseases. Aberrant expression...
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The Expression Analysis of Long Non-coding RNAs Related to Wnt/β-Catenin Signaling in Pancreatic Cancer Patients
Background The oncogenic Wnt/ β -catenin signaling plays a critical role in carcinogenesis, prognosis, and resistance to therapy. Pancreatic cancer...
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The Role of lncRNA-miR-26a-mRNA Network in Cancer Progression and Treatment
The role of non-coding RNAs in regulating biological processes associated with cancer progression, such as proliferation, migration, and apoptosis,...
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LncRNA weighted gene co-expression network analysis reveals novel biomarkers related to prostate cancer metastasis
BackgroundMost prostate cancer patients die from metastasis and lack accurate efficacious biomarkers to monitor the disease behavior, optimize...
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LncRNA HCG11 promotes proliferation and migration in gastric cancer via targeting miR-1276/CTNNB1 and activating Wnt signaling pathway
BackgroundGastric cancer (GC) is one common cancer which occurs in the stomach leading to high mortality around the world. Long non-coding RNAs...
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A Novel Cuprotosis-Related lncRNA Signature Effectively Predicts Prognosis in Glioma Patients
Cuprotosis is a novel and different cell death mechanism from the existing known ones that can be used to explore new approaches to treating cancer....
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Expression and regulatory roles of lncRNAs in G-CIMP-low vs G-CIMP-high Glioma: an in-silico analysis
BackgroundClinically relevant glioma subtypes, such as the glioma-CpG island methylator phenotype (G-CIMP), have been defined by epigenetics. In this...
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Pivotal functions and impact of long con-coding RNAs on cellular processes and genome integrity
Recent advances in uncovering the mysteries of the human genome suggest that long non-coding RNAs (lncRNAs) are important regulatory components....
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Emerging role of RNA modification and long noncoding RNA interaction in cancer
RNA modification, especially N6-methyladenosine, 5-methylcytosine, and N7-methylguanosine methylation, participates in the occurrence and progression...
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Role of long non-coding RNAs in metabolic reprogramming of gastrointestinal cancer cells
Metabolic reprogramming, which is recognized as a hallmark of cancer, refers to the phenomenon by which cancer cells change their metabolism to...
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Novel insights into mutual regulation between N6-methyladenosine modification and LncRNAs in tumors
N 6 -methyladenosine (m 6 A), one of the most common RNA methylation modifications, has emerged in recent years as a new layer of the regulatory...
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AI as a Novel Approach for Exploring ccfNAs in Personalized Clinical Diagnosis and Prognosis: Providing Insight into the Decision-Making in Precision Oncology
For many years the idea of personalized medicine has toyed around. It is characterized as an innovative method to alter disease treatment and...
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Long Non-coding RNAs: Potential Players in Cardiotoxicity Induced by Chemotherapy Drugs
One of the most important side effects of chemotherapy is cardiovascular complications, such as cardiotoxicity. Many factors are involved in the...
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Molecular Landscape of LncRNAs in Prostate Cancer: A focus on pathways and therapeutic targets for intervention
BackgroundOne of the most malignant tumors in men is prostate cancer that is still incurable due to its heterogenous and progressive natures. Genetic...
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G-quadruplexes from non-coding RNAs
Non-coding RNAs (ncRNAs) are significant regulators of gene expression in a wide range of biological processes, such as transcription, RNA...
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Notch-associated lncRNAs profiling circuiting epigenetic modification in colorectal cancer
BackgroundColorectal cancer (CRC) is one of the most prevalent digestive cancers, ranking the 2nd cause of cancer-related fatality worldwide. The...
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Osteosarcoma in a ceRNET perspective
Osteosarcoma (OS) is the most prevalent and fatal type of bone tumor. It is characterized by great heterogeneity of genomic aberrations, mutated...
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Long non-coding RNA profiling of pediatric Medulloblastoma
BackgroundMedulloblastoma (MB) is one of the most common malignant cancers in children. MB is primarily classified into four subgroups based on...
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The roles and molecular mechanisms of non-coding RNA in cancer metabolic reprogramming
One of the key features of cancer is energy metabolic reprogramming which is tightly related to cancer proliferation, invasion, metastasis, and...
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Computational Analysis of lncRNA Function in Cancer
Long noncoding RNAs (lncRNAs) have been shown to play crucial roles in cancer biology. With the help of computational analysis illustrated here, the...