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Prenatal diagnosis of 1408 foetuses at risk of DMD/BMD by MLPA and Sanger sequencing combined with STR linkage analysis
ObjectiveThis study is a retrospective analysis of the prenatal genetic diagnosis results of 1408 foetuses at high risk of DMD/BMD to provide...
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Application of the PGT-M strategy using single sperm and/or affected embryos as probands for linkage analysis in males with hereditary tumor syndromes without family history
Hereditary tumor syndromes have garnered substantial attention due to their adverse effects on both the physical and psychological health of...
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Genome-wide linkage analysis combined with genome sequencing in large families with intracranial aneurysms
Rupture of an intracranial aneurysm (IA) leads to aneurysmal subarachnoid haemorrhage (ASAH), a severe type of stroke. Some rare variants that cause...
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Fine map** of the Cepaea nemoralis shell colour and mid-banded loci using a high-density linkage map
Molluscs are a highly speciose phylum that exhibits an astonishing array of colours and patterns, yet relatively little progress has been made in...
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Self-reported HPV vaccination and vaccination record linkage in the Australian Oral Diversity Study
PurposeAustralia has a school-based human papillomavirus (HPV) vaccination scheme that was implemented for girls in 2007 and for boys in 2013. HPV...
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Record linkage based patient intersection cardinality for rare disease studies using Mainzelliste and secure multi-party computation
BackgroundThe low number of patients suffering from any given rare diseases poses a difficult problem for medical research: With the exception of...
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Genome-wide linkage search for cancer susceptibility loci in a cohort of non BRCA1/2 families in Sri Lanka
ObjectiveAlthough linkage studies have been utilized for the identification of variants associated with cancer in the world, little is known about...
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Noninvasive fetal genoty** of single nucleotide variants and linkage analysis for prenatal diagnosis of monogenic disorders
BackgroundHigh-cost, time-consuming and complex processes of several current approaches limit the use of noninvasive prenatal diagnosis (NIPD) for...
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Adjuvant radiation therapy and health-related quality of life among older women with early-stage endometrial cancer: an analysis using the SEER-MHOS linkage
PurposeRadiation therapy (RT) has been associated with decreased health-related quality of life (HRQOL) in clinical trials of early-stage endometrial...
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Linkage Map Construction and QTL Map** for Salt Tolerance in the Seedlings of Dongxiang Wild Rice (Oryza rufipogon Griff.)
AbstractSalt stress causes significant reductions in rice production worldwide; thus, improving salt tolerance is a promising approach to meet the...
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ReporTree: a surveillance-oriented tool to strengthen the linkage between pathogen genetic clusters and epidemiological data
BackgroundGenomics-informed pathogen surveillance strengthens public health decision-making, playing an important role in infectious diseases’...
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Linkage Analysis of Genes Controlling the Qualitative Characteristics of Barley Plants in Chromosome 6
AbstractOn the basis of the genetic analysis of F 2 by F 3 in the combination M13 × r “e” + o, the recombination frequencies between genetic factors...
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Extremely sparse models of linkage disequilibrium in ancestrally diverse association studies
Linkage disequilibrium (LD) is the correlation among nearby genetic variants. In genetic association studies, LD is often modeled using large...
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Development of first linkage map for Silphium integrifolium (Asteraceae) enables identification of sporophytic self-incompatibility locus
Silphium integrifolium ( Asteraceae ) has been identified as a candidate for domestication as a perennial oilseed crop and is assumed to have...
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Establishing a framework for privacy-preserving record linkage among electronic health record and administrative claims databases within PCORnet®, the National Patient-Centered Clinical Research Network
ObjectiveThe aim of this study was to determine whether a secure, privacy-preserving record linkage (PPRL) methodology can be implemented in a...
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A Recombination Suppressed Region of Sunflower (Helianthus annuus L.) Linkage Group 13 Covers Restoration of Fertility (Rf1) and Downy Mildew Resistance (Pl) Gene Clusters
AbstractA number of genes that control traits that are valuable for breeding introgressed from wild relatives, i.e., pollen-fertility restoration and...
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The linkage of NF-κB signaling pathway-associated long non-coding RNAs with tumor microenvironment and prognosis in cervical cancer
BackgroundNF-κB signaling pathway participate closely in regulating inflammation and immune response in many cancers. Long non-coding RNAs (lncRNAs)...
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Optimization of the Mainzelliste software for fast privacy-preserving record linkage
BackgroundData analysis for biomedical research often requires a record linkage step to identify records from multiple data sources referring to the...
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Combined effects of glycan chain length and linkage type on the immunogenicity of glycoconjugate vaccines
The development and use of antibacterial glycoconjugate vaccines have significantly reduced the occurrence of potentially fatal childhood and adult...
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A Pyrene Coupled Azaine-linkage Chromo-fluorogenic Probe for Specific Detection of Sarin Gas Stimulant, Diethylchlorophosphate
Owing to the extreme toxicity and easy synthesis protocol of G-series nerve agents, develo** an efficient sensor for selective detection is...
