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Leonurine Hydrochloride Suppresses Inflammatory Responses and Ameliorates Cartilage Degradation in Osteoarthritis via NF-κB Signaling Pathway
Leonurine hydrochloride (LH) has been reported to exhibit a number of biological properties such as suppression of inflammation. This study aimed to...
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Phytochemicals as potential target on thioredoxin-interacting protein (TXNIP) for the treatment of cardiovascular diseases
Cardiovascular diseases (CVDs) are currently the major cause of death and morbidity on a global scale. Thioredoxin-interacting protein (TXNIP) is a...
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Pathway and Genomics of Immunomodulator Natural Products
Immune dysfunction has become a major public health problem, so the search for natural products with efficacy, safety, and therapeutic effects on the...
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New Data on the Pathophysiology of Ischemic Stroke: Epigenetic Mechanisms in Focus
Epigenetics is a branch of molecular biology studying modifications able to change the expression of genes without altering their DNA sequences....
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Soy isoflavones induces mitophagy to inhibit the progression of osteosarcoma by blocking the AKT/mTOR signaling pathway
BackgroundSoy isoflavones (SI) is a natural bioactive substance exhibiting beneficial effects on human health. This study aims to elucidate the...
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Acacetin targets STING to alleviate the destabilization of the medial meniscus-induced osteoarthritis in mice
Osteoarthritis (OA) is a common joint disorder affecting about 7% of the global population, primarily characterized by the gradual loss of articular...
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Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression
Major depressive disorder is a highly debilitating psychiatric disorder involving the dysfunction of different cell types in the brain. Microglia are...
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TRPA1 promotes cisplatin-induced acute kidney injury via regulating the endoplasmic reticulum stress-mitochondrial damage
BackgroundCisplatin is a widely used and effective chemotherapeutic agent against cancer. However, nephrotoxicity is one of the most common side...
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Ferroptosis and cuproptposis in kidney Diseases: dysfunction of cell metabolism
Metal ions play an important role in living organisms and are involved in essential physiological activities. However, the overload state of ions can...
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Traditional Indian Knowledge of Immunity from Plants
The traditional Indian medicine like Ayurveda and Siddha and traditional Chinese medicine remain the most ancient therapies. While Ayurveda...
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Phytochemicals as potential IKK-β inhibitor for the treatment of cardiovascular diseases in plant preservation: terpenoids, alkaloids, and quinones
Modulation of inhibitor kappa B kinase-beta (IKK-β) kinase activity could be useful for preventing inflammation that serves an efficient role in...
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Mono-macrophage-Derived MANF Protects Against Lipopolysaccharide-Induced Acute Kidney Injury via Inhibiting Inflammation and Renal M1 Macrophages
The outburst of renal inflammatory response has been found to be a crucial cause of acute kidney injury (AKI). Attenuating the renal inflammation is...
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Anti-apoptosis effect of traditional Chinese medicine in the treatment of cerebral ischemia–reperfusion injury
Cerebral ischemia, one of the leading causes of neurological dysfunction of brain cells, muscle dysfunction, and death, brings great harm and...
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Clematichinenoside AR Alleviates Foam Cell Formation and the Inflammatory Response in Ox-LDL-Induced RAW264.7 Cells by Activating Autophagy
Foam cell formation and inflammation in macrophages contribute to the development of atherosclerosis (AS). Clematichinenoside AR (AR) is a major...
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The Cardiovascular Effects of Hydrogen Sulfide: The Epigenetic Mechanisms
Hydrogen sulfide (H2S), known as a gas signal molecule, plays an important role in the development of cardiovascular diseases (CVD) through...
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Medicinal Herbs Used in Herbal Medicine for Neurological Disorders
A. julibrissin is native to Asia and popularly known as Persian silk tree. In traditional Chinese medicine, it is used to treat anxiety and...
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Stem Cell Transplants in the Aged Stroke Brain: Microenvironment Factors
In aged humans, stroke is a major cause of disability for which no neuroprotective measures are available. The incidence of stroke increases...
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Yimu San improves obstetric ability of pregnant mice by increasing serum oxytocin levels and connexin 43 expression in uterine smooth muscle
Prolonged farrowing remains one of the critical challenges in intensive pig farming. This study aims to explore the effects and mechanism of Yimu San...
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A study on the PK and BA profiles in the mouse body for leonurine O/O microemulsion with determination by the LC-MS/MS method
Leonurine (LE) has been found to have therapeutic efficacy in cerebral thrombosis, but its poor solubility in water leads to very low...
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Leonurine Exerts Anti-Inflammatory Effect by Regulating Inflammatory Signaling Pathways and Cytokines in LPS-Induced Mouse Mastitis
Bovine mastitis is defined as the inflammation of mammary gland and is the most multiple diseases in dairy cattle. There is still no effective...
