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Combination effects of amino acid transporter LAT1 inhibitor nanvuranlat and cytotoxic anticancer drug gemcitabine on pancreatic and biliary tract cancer cells
BackgroundCytotoxic anticancer drugs widely used in cancer chemotherapy have some limitations, such as the development of side effects and drug...
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Blockade of the amino acid transporter SLC6A14 suppresses tumor growth in colorectal Cancer
BackgroundThe amino acid transporter SLC6A14, which transports 18 of the 20 proteinogenic amino acids, is too low to be detected in healthy normal...
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Olig2-astrocytes express neutral amino acid transporter SLC7A10 (Asc-1) in the adult brain
We have reported that the transcription factor Olig2 labels a subpopulation of astrocytes (Olig2-astrocytes), which show distribution patterns...
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Amino acid metabolism reprogramming: shedding new light on T cell anti-tumor immunity
Metabolic reprogramming of amino acids has been increasingly recognized to initiate and fuel tumorigenesis and survival. Therefore, there is emerging...
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Plasmodium falciparum: Transporter and Drug Target
Malaria will continue to be a concern for public health well into the future, as it is responsible for more than 50 million fatalities annually...
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Protein kinase C activation upregulates human L-type amino acid transporter 2 function
L-type amino acid transporter 2 (LAT2) is a Na + -independent neutral amino acid transporter, whose function regulation system remains unclarified....
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Constructing a Novel Amino Acid Metabolism Signature: A New Perspective on Pheochromocytoma Diagnosis, Immune Landscape, and Immunotherapy
Pheochromocytoma/paraganglioma (PGPG) is a rare neuroendocrine tumor. Amino acid metabolism is crucial for energy production, redox balance, and...
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Vitamin C transporter SVCT1 serves a physiological role as a urate importer: functional analyses and in vivo investigations
Uric acid, the end product of purine metabolism in humans, is crucial because of its anti-oxidant activity and a causal relationship with...
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Astrocyte Glutamate Transporter EAAT2 in Alzheimer Dementia
Glutamate is an amino acid and also the major synaptic signaling molecule of neurons, essential in cognition, learning, and memory. Glutamate is...
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Glutathione transporter as a target for brain drug delivery
Inability to achieve therapeutic concentrations of a medication in the brain due to the blood brain barrier (BBB) is the major cause of treatment...
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MicroRNA-mediated reprogramming of glucose, fatty acid and amino acid metabolism in cancer
Cancer cells possess a unique metabolic phenotype, rewiring their metabolic pathways to support energy-intensive and biosynthetic requirements for...
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Kinetic profiling of novel spirobenzo-oxazinepiperidinone derivatives as equilibrative nucleoside transporter 1 inhibitors
Evaluation of kinetic parameters of drug-target binding, k on , k off , and residence time (RT), in addition to the traditional in vitro parameter of...
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L-Type amino acid transporter 1 as a target for drug delivery
Our growing understanding of membrane transporters and their substrate specificity has opened a new avenue in the field of targeted drug delivery....
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Coordinated Regulation of Myelination by Growth Factor and Amino-acid Signaling Pathways
Myelin-forming oligodendrocytes in the central nervous system (CNS) and Schwann cells in the peripheral nervous system (PNS) are essential for...
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Functional characterization of Clonorchis sinensis sodium-bile acid co-transporter (CsSBAT) as a steroid sulfate transporter
Clonorchis sinensis (Cs) is a common trematode in Asian countries. Infection by Cs can result in many clinical symptoms. Here, a cDNA encoding a Cs...
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Exploiting Apical Sodium-Dependent Bile Acid Transporter (ASBT)-Mediated Endocytosis with Multi-Functional Deoxycholic Acid Grafted Alginate Amide Nanoparticles as an Oral Insulin Delivery System
ObjectiveOral administration of insulin is a potential candidate for managing diabetes. However, it is obstructed by the gastrointestinal tract...
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Proteomic Analysis of the Amygdala Reveals Dynamic Changes in Glutamate Transporter-1 During Progression of Complete Freund’s Adjuvant-Induced Pain Aversion
Pain sufferer usually show an aversion to the environment associated with pain, identified as pain aversion. The amygdala, an almond-shaped limbic...
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Mast Cells are Dependent on Glucose Transporter 1 (GLUT1) and GLUT3 for IgE-mediated Activation
Mast cells (MCs) are known to have a pathological impact in a variety of settings, in particular in allergic conditions. There is also limited...
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Interaction of the chemotherapeutic agent oxaliplatin and the tyrosine kinase inhibitor dasatinib with the organic cation transporter 2
Oxaliplatin (OHP) is effective in colorectal cancer treatment but induces peripheral neurotoxicity (OHP-induced peripheral neurotoxicity, OIPN),...
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Protein Expression of Amino Acid Transporters Is Altered in Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer’s Disease
Membrane transporters such as ATP-binding cassette (ABC) and solute carrier (SLC) transporters expressed at the neurovascular unit (NVU) play an...
