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Neuroprotection by Kynurenine Metabolites
The overexcitation of excitatory amino acid receptors generates excitotoxicity, which plays an important role in the pathophysiology of various...
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Tryptophan-kynurenine metabolic pathway and daytime dysfunction in women with HIV
Sleep disturbances are prevalent in women with HIV (WWH). Tryptophan-kynurenine (T-K) pathway metabolites are associated with alterations in...
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Frontostriatal circuitry and the tryptophan kynurenine pathway in major psychiatric disorders
RationaleAn imbalance of the tryptophan kynurenine pathway (KP) commonly occurs in psychiatric disorders, though the neurocognitive and network-level...
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Tryptophan catabolism via the kynurenine pathway regulates infection and inflammation: from mechanisms to biomarkers and therapies
Backgroundl -Tryptophan ( l -Trp), an essential amino acid, is the only amino acid whose level is regulated specifically by immune signals. Most...
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Stress and Kynurenine-Inflammation Pathway in Major Depressive Disorder
Major depressive disorder (MDD) is one of the most prevalent disorders and causes severe damage to people’s quality of life. Lifelong stress is one...
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Dysregulation of the Kynurenine Pathway, Cytokine Expression Pattern, and Proteomics Profile Link to Symptomology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Dysregulation of the kynurenine pathway (KP) is believed to play a significant role in neurodegenerative and cognitive disorders. While some evidence...
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MM165 - A Small Hybrid Molecule Modulates the Kynurenine Pathway and Attenuates Lipopolysaccharide-Induced Memory Deficits and Inflammation
Cognitive dysfunctions are now recognized as core symptoms of various psychiatric disorders e.g., major depressive disorder. Sustained immune...
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Association Study Between Kynurenine 3-Monooxygenase (KMO) Gene and Parkinson’s Disease Patients
The influence of various risk factors such as aging, intricate cellular molecular processes, and lifestyle factors like smoking, alcohol consumption,...
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Involvement of the kynurenine pathway in breast cancer: updates on clinical research and trials
Breast cancer (BrCa) is the leading cause of cancer incidence and mortality in women worldwide. While BrCa treatment has been shown to be highly...
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First trimester human umbilical cord perivascular cells (HUCPVC) modulate the kynurenine pathway and glutamate neurotransmission in an LPS-induced mouse model of neuroinflammation
BackgroundThe Kynurenine Pathway (KP) of tryptophan degradation and glutamate toxicity is implicated in several neurological disorders, including...
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Kynurenine Metabolism and Alzheimer’s Disease: The Potential Targets and Approaches
l -tryptophan, an essential amino acid, regulates protein homeostasis and plays a role in neurotransmitter-mediated physiological events. It also...
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Involvement of kynurenine pathway between inflammation and glutamate in the underlying etiopathology of CUMS-induced depression mouse model
Inflammation and glutamate (GLU) are widely thought to participate in the pathogenesis of depression, and current evidence suggests that the...
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Ido2 Deficiency Exacerbates Motor Impairment and Reduces Aryl Hydrocarbon Receptor Activity through Decreased Kynurenine in a Chronic Demyelinating Mouse Model
Demyelinating diseases including multiple sclerosis (MS) are chronic inflammatory diseases of the central nervous system. Indoleamine 2,3-dioxygenase...
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Increased Hippocampal Afterdischarge Threshold in Ketogenic Diet is Accompanied by Enhanced Kynurenine Pathway Activity
The efficacy of a ketogenic diet (KD) in controlling seizure has been shown in many experimental and clinical studies, however, its mechanism of...
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IDO/kynurenine pathway in cancer: possible therapeutic approaches
Cancer is one of the leading causes of death in both men and women worldwide. One of the main changes associated with cancer progression, metastasis,...
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High-fat diet-disturbed gut microbiota-colonocyte interactions contribute to dysregulating peripheral tryptophan-kynurenine metabolism
BackgroundAberrant tryptophan (Trp)-kynurenine (Kyn) metabolism has been implicated in the pathogenesis of human disease. In particular, populations...
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Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR–RUNX1
Tumor-derived factors are thought to regulate thrombocytosis and erythrocytopenia in individuals with cancer; however, such factors have not yet been...
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Acute administration of ibuprofen increases serum concentration of the neuroprotective kynurenine pathway metabolite, kynurenic acid: a pilot randomized, placebo-controlled, crossover study
RationaleAt least six different types of antidepressant treatments have been shown to either increase the neuroprotective kynurenine pathway (KP)...
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A pilot investigation of the association between HIV-1 Vpr amino acid sequence diversity and the tryptophan-kynurenine pathway as a potential mechanism for neurocognitive impairment
HIV infection compromises both the peripheral and central immune systems due to its pathogenic and neuropathogenic features. The mechanisms driving...
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Kynurenine in IDO1high cancer cell-derived extracellular vesicles promotes angiogenesis by inducing endothelial mitophagy in ovarian cancer
BackgroundMitophagy, a prominent cellular homeostasis process, has been implicated in modulating endothelial cell function. Emerging evidence...
