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Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo
AbstractCytoplasmic aggregation and concomitant nuclear clearance of the RNA-binding protein TDP-43 are found in ~ 90% of cases of amyotrophic...
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Intrinsic and extrinsic actions of human neural progenitors with SUFU inhibition promote tissue repair and functional recovery from severe spinal cord injury
Neural progenitor cells (NPCs) derived from human pluripotent stem cells(hPSCs) provide major cell sources for repairing damaged neural circuitry and...
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Neurogenesis and neuronal differentiation in the postnatal frontal cortex in Down syndrome
Although Down syndrome (DS), the most common developmental genetic cause of intellectual disability, displays proliferation and migration deficits in...
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CD36 deletion prevents white matter injury by modulating microglia polarization through the Traf5-MAPK signal pathway
BackgroundWhite matter injury (WMI) represents a significant etiological factor contributing to neurological impairment subsequent to Traumatic Brain...
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Immunology of Neuro-Behcet’s Disease (NBD)
A complex genetic background leading to a pro-inflammatory, innate immune system-derived activation perpetuated by adaptive immune responses against...
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Treating Traumatic Brain Injury with Minocycline
Traumatic brain injury (TBI) results in both rapid and delayed brain damage. The speed, complexity, and persistence of TBI present large obstacles to...
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BI1 Activates Autophagy and Mediates TDP43 to Regulate ALS Pathogenesis
Amyotrophic lateral sclerosis (ALS) is the most prevalent motor neuron disease in adults. Currently, there are no known drugs or clinical approaches...
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The neuropathologic findings in a case of progressive cavitating leukoencephalopathy due to NDUFV1 pathogenic variants
Pathogenic variants in the NDUFV1 gene, which codes for complex I of the mitochondrial respiratory chain, have been associated with a variety of...
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Calpain as a Therapeutic Target for Hypoxic-Ischemic Encephalopathy
Hypoxic-ischemic encephalopathy (HIE) is a complex pathophysiological process with multiple links and factors. It involves the interaction of...
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An Understanding of Different Mechanisms Leading to Neurodegenerative Diseases
The prevalence of neurodegenerative disorders is rapidly increasing causing high morbidity and cognitive deterioration in the elder population....
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Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease
Neurofilament light chain (NfL) is a promising fluid biomarker of disease progression for various cerebral proteopathies. Here we leverage the unique...
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Long Non-coding RNA ANRIL and Its Role in the Development of Age-Related Diseases
ANRIL is known as a lncRNA that has many linear and circular isoforms and its polymorphisms are observed to be associated with the pathogenesis of...
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Molecular Biomarkers of Neuronal Injury in Epilepsy Shared with Neurodegenerative Diseases
In neurodegenerative diseases, changes in neuronal proteins in the cerebrospinal fluid and blood are viewed as potential biomarkers of the primary...
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Plasma neurofilament light as a potential biomarker of neurodegeneration in Alzheimer’s disease
BackgroundA growing body of evidence suggests that the plasma concentration of the neurofilament light chain (NfL) might be considered a plasma...
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Selective targeting and modulation of plaque associated microglia via systemic hydroxyl dendrimer administration in an Alzheimer’s disease mouse model
BackgroundIn Alzheimer’s disease (AD), microglia surround extracellular plaques and mount a sustained inflammatory response, contributing to the...
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Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia
BackgroundProgranulin (PGRN) haploinsufficiency due to progranulin gene ( GRN ) variants can cause frontotemporal dementia (FTD) with aberrant TAR...
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Driving Mitochondrial Fission Improves Cognitive, but not Motor Deficits in a Mouse Model of Ataxia of Charlevoix-Saguenay
Autosomal-recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is caused by loss-of-function mutation in the SACS gene, which encodes sacsin, a...
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Enterovirus-A71 exploits RAB11 to recruit chaperones for virus morphogenesis
BackgroundEnterovirus 71 (EV-A71) causes Hand, Foot and Mouth Disease (HFMD) in children and has been associated with neurological complications. The...
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Activation of P2Y2 Receptors Promotes Neuromuscular Junction Formation during Muscle Reinnervation
AbstractExtracellular adenosine 5′-triphosphate (ATP), as neurotransmitter, is known to be an activity-dependent signaling molecule that regulates...
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Exposure to Aluminum in Daily Life and Alzheimer’s Disease
Aluminum has often been regarded as not having a significant health hazard. Consequently, aluminum-containing agents have been used in the...