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Optimal adjuvant therapy in older (≥70 years of age) women with low-risk early-stage breast cancer
Older women are under-represented in breast cancer (BC) clinical trials, and treatment guidelines are primarily based on BC studies in younger women....
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Current Treatment Approaches to Breast Cancer
Breast cancer is a familiar malignancy and the major reason for cancer mortality among females worldwide. Research on breast carcinoma has led to...
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Effects of systemic inflammation on relapse in early breast cancer
Chronic inflammation has been a proposed mechanism of resistance to aromatase inhibitors in breast cancer. Stratifying by HER2 status, a matched...
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Hypofractionated radiotherapy with simultaneous tumor bed boost (Hi-RISE) in breast cancer patients receiving upfront breast-conserving surgery: study protocol for a phase III randomized controlled trial
BackgroundThe effectiveness and safety of moderately hypofractionated radiotherapy (HFRT) in patients undergoing breast-conserving surgery (BCS) has...
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Toxicity of external beam accelerated partial-breast irradiation (APBI) in adjuvant therapy of early-stage breast cancer: prospective randomized study
BackgroundAccelerated partial breast irradiation (APBI) is an alternative breast-conserving therapy approach where radiation is delivered in less...
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Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors
BackgroundTriple-negative breast cancer (TNBC) is an aggressive subtype that exhibits a high incidence of distant metastases and lacks targeted...
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Prediction of pathologic complete response after single-dose MR-guided partial breast irradiation in low-risk breast cancer patients: the ABLATIVE-2 trial—a study protocol
BackgroundPartial breast irradiation (PBI) is standard of care in low-risk breast cancer patients after breast-conserving surgery (BCS)....
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Efficacy and safety analysis of hypofractionated and conventional fractionated radiotherapy in postoperative breast cancer patients
ObjectivesIn this meta-analysis, we conducted a comparative analysis of the safety and efficacy of hypofractionated and conventional fractionated...
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Serum protein profiling reveals an inflammation signature as a predictor of early breast cancer survival
BackgroundBreast cancers exhibit considerable heterogeneity in their biology, immunology, and prognosis. Currently, no validated, serum protein-based...
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Distribution, dynamic evolution, and clinical outcomes of patients with advanced breast cancer according to HER2 expression
BackgroundNovel antibody‒drug conjugates (ADC) have shown great efficacy in HER2-low advanced breast cancer. However, the clinical features of...
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The impact of bolus on clinical outcomes for post-mastectomy breast cancer patients treated with IMRT: data from China
PurposeThis study aims to investigate the effects of chest wall bolus in intensity-modulated radiotherapy (IMRT) technology on clinical outcomes for...
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Impact of time to distant recurrence on breast cancer-specific mortality in hormone receptor-positive breast cancer
Women with hormone receptor (HR)-positive early-stage breast cancer (BC) have five-year survival rates of > 90% but remain at serious risk for...
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Intraoperative electron radiotherapy in early invasive ductal breast cancer: 6-year median follow-up results of a prospective monocentric registry
BackgroundIntraoperative electron radiotherapy (IOERT) can be used to treat early breast cancer during the conservative surgery thus enabling shorter...
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Associations amongst genes, molecules, cells, and organs in breast cancer metastasis
This paper is a cross fertilization of ideas about the importance of molecular aspects of breast cancer metastasis by basic scientists, a...
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Development and validation of an AI-enabled digital breast cancer assay to predict early-stage breast cancer recurrence within 6 years
BackgroundBreast cancer (BC) grading plays a critical role in patient management despite the considerable inter- and intra-observer variability,...
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MMP-11 expression in early luminal breast cancer: associations with clinical, MRI, pathological characteristics, and disease-free survival
BackgroundEarly hormone-positive breast cancers typically have favorable outcomes, yet long-term surveillance is crucial due to the risk of late...
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Breast Cancer Recurrence and Survival
Recurrence of breast cancer is a major cause of the disease-specific death. In general, it occurs within 5 years or even up to 10–20 years after...
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MRI-based breast cancer radiogenomics using RNA profiling: association with subtypes in a single-center prospective study
BackgroundThere are few prospective studies on the correlations between MRI features and whole RNA-sequencing data in breast cancer according to...
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Pathological complete response, category change, and prognostic significance of HER2-low breast cancer receiving neoadjuvant treatment: a multicenter analysis of 2489 cases
BackgroundHER2-low breast cancers (BC) show a good response to novel anti-HER2 antibody-drug conjugates (ADCs) in advanced setting. Nevertheless,...
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Epigenetic activation of SOX11 is associated with recurrence and progression of ductal carcinoma in situ to invasive breast cancer
BackgroundRisk of recurrence and progression of ductal carcinoma in situ (DCIS) to invasive cancer remains uncertain, emphasizing the need for...
