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The Neurobiological Role of Lithium Salts
Lithium salts have been the mainstay of treatment for bipolar disorder for more than 50 years, since approval by the FDA in 1970 for the treatment of...
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Metabolic effects of diclofenac on the aquatic food chain – 1 H-NMR study of water flea-zebrafish system
In the environment, aquatic organisms are not only directly exposed to pollutants, but the effects can be exacerbated along the food chain. In this...
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Future Prospects on Synergistic Herb-Drug Interactions
In the recent decades, a substantial progress has been made in the field of drug-drug and adverse herb-drug interactions. Synergistic herb-drug...
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Systematic analysis based on the cuproptosis-related genes identifies ferredoxin 1 as an immune regulator and therapeutic target for glioblastoma
Glioblastoma multiforme (GBM) is recognized as the prevailing malignant and aggressive primary brain tumor, characterized by an exceedingly...
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NMR-Based Metabolomics of Rat Hippocampus, Serum, and Urine in Two Models of Autism
Autism spectrum disorders (ASDs) are increasingly diagnosed as developmental disabilities of unclear etiology related to genetic, epigenetic, or...
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Metabolomics in Depression: What We Learn from Preclinical and Clinical Evidences
Depression is one of the predominant common mental illnesses that affects millions of people of all ages worldwide. Random mood changes, loss of...
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Multi-omics Analysis of Young Portulaca oleracea L. Plants’ Responses to High NaCl Doses Reveals Insights into Pathways and Genes Responsive to Salinity Stress in this Halophyte Species
Soil salinity is among the abiotic stressors that threaten agriculture the most, and purslane ( Portulaca oleracea L.) is a dicot species adapted to...
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The subacute toxicity and underlying mechanisms of biomimetic mesoporous polydopamine nanoparticles
Recently, mesoporous nanomaterials with widespread applications have attracted great interest in the field of drug delivery due to their unique...
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The Promise of Niacin in Neurology
Niacin (vitamin B3) is an essential nutrient that treats pellagra, and prior to the advent of statins, niacin was commonly used to counter...
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Research progress on the mechanism of curcumin in cerebral ischemia/reperfusion injury: a narrative review
Cerebral ischemia/reperfusion (I/R) injury can result in different levels of cerebral impairment, and in severe cases, death. Curcumin, an essential...
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Exploring novel cap** framework: high substituent pyridine-hydroxamic acid derivatives as potential antiproliferative agents
PurposeHistone deacetylases (HDACs) play a vital role in the epigenetic regulation of gene expression due to their overexpression in several cancer...
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Metabolomics of Glioma
Metabolic reprogramming is an important characteristics of glioma, the most common form of malignant brain tumor. In this chapter, we aim to discuss...
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Profiles of urine and blood metabolomics in autism spectrum disorders
Early diagnosis and treatment for autism spectrum disorder (ASD) pose challenges. The current diagnostic approach for ASD is mainly clinical...
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Untargeted serum metabolic profiling of diabetes mellitus among Parkinson’s disease patients
Type 2 diabetes mellitus (T2DM) is a common comorbidity among Parkinson’s disease (PD) patients. Yet, little is known about dysregulated pathways...
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Behavioral, Hormonal, Inflammatory, and Metabolic Effects Associated with FGF21-Pathway Activation in an ALS Mouse Model
In amyotrophic lateral sclerosis (ALS), motor neuron degeneration occurs simultaneously with systemic metabolic dysfunction and neuro-inflammation....
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Comparison of Metabolic Profiling of Arabidopsis Inflorescences Between Landsberg erecta and Columbia, and Meiosis-Defective Mutants by 1H-NMR Spectroscopy
With the rapid development of omics technologies during the last several decades, genomics, transcriptomics, and proteomics have been extensively...
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Anthocyanin improves kidney function in diabetic kidney disease by regulating amino acid metabolism
BackgroundDiabetic kidney disease (DKD) is among the most important causes for chronic kidney disease. Anthocyanins (ANT) are polyphenolic compounds...
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Metabolic alterations in the erythrocyte during blood-stage development of the malaria parasite
BackgroundHuman blood cells (erythrocytes) serve as hosts for the malaria parasite Plasmodium falciparum during its 48-h intraerythrocytic...
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Salivary and Urinary Metabolome in Pediatric Obesity and Metabolic Syndrome
Childhood obesity is reaching alarming rates in many countries, posing an urgent and serious challenge. Adipose tissue is a key endocrine organ that...
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Computational analysis of receptor tyrosine kinase inhibitors and cancer metabolism: implications for treatment and discovery of potential therapeutic signatures
BackgroundReceptor tyrosine kinase (RTK) inhibitors are frequently used to treat cancers and the results have been mixed, some of these small...
