Search
Search Results
-
Liraglutide Reduces Alcohol Consumption, Anxiety, Memory Impairment, and Synapse Loss in Alcohol Dependent Mice
Glucagon-like peptide 1 (GLP-1) analogues have been commercialized for the management of type 2 diabetes. Recent studies have underscored GLP-1’s...
-
Effect of the glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide on alcohol consumption in alcohol-preferring male vervet monkeys
RationaleGlucagon-like peptide-1 (GLP-1) receptor agonists reduce alcohol consumption in rodents and non-human primates. Semaglutide is a new...
-
Alcohol: Neurobiology of Alcohol Addiction
Consumption of alcohol is the third leading cause of preventable deaths worldwide making it a major public health issue. After a brief account of the...
-
Psilocybin prevents reinstatement of alcohol seeking by disrupting the reconsolidation of alcohol-related memories
BackgroundFor most psychiatric conditions, including alcohol use disorder (AUD), FDA-approved pharmacological treatments are limited and their...
-
Differential effects of early exposure to alcohol on alcohol preference and blood alcohol levels in low- and high-anxious rats
Emotional disturbances emerge following alcohol withdrawal. The anxiolytic effect of alcohol may be one important motivation for its consumption in...
-
Anti-inflammatory drugs prevent memory and hippocampal plasticity deficits following initial binge-like alcohol exposure in adolescent male rats
RationaleBinge drinking during adolescence impairs learning and memory on the long term, and many studies suggest a role of neuroinflammation....
-
Details in Conducting Human Laboratory Alcohol Administration and Self-Administration Experiments to Assess Subjective Response and Craving for Alcohol
Human laboratory methods are valuable approaches to studying the etiology of alcohol misuse and interventions to ameliorate misuse because they offer...
-
Intravenous Alcohol Administration Studies in Humans: Investigator-Prescribed and Self-Administration Paradigms
Alcohol administration experiments, or sometimes termed alcohol challenges, fall into two classes: those in which the investigator determines the...
-
Subthalamic high-frequency deep brain stimulation reduces addiction-like alcohol use and the possible negative influence of a peer presence
RationaleThe immediate social context significantly influences alcohol consumption in humans. Recent studies have revealed that peer presence could...
-
The anterior insula and its projection to amygdala nuclei modulate the abstinence-exacerbated expression of conditioned place preference
RationaleRelapse into substance use is often triggered by exposure to drug-related environmental cues. The magnitude of drug seeking depends on the...
-
GDNF gene therapy for alcohol use disorder in male non-human primates
Alcohol use disorder (AUD) exacts enormous personal, social and economic costs globally. Return to alcohol use in treatment-seeking patients with AUD...
-
Behavioral economic analysis of topiramate pharmacotherapy for alcohol: a placebo-controlled investigation of effects on alcohol reinforcing value and delayed reward discounting
RationalePharmacotherapies are an important clinical strategy for treating alcohol use disorder and an understanding of their functional mechanisms...
-
Intravenous Alcohol Self-Administration Using a Progressive Ratio Schedule of Reinforcement in Clinical Studies
Operant self-administration paradigms are commonly used in preclinical and clinical studies as a way to experimentally observe individuals’ alcohol...
-
Excessive alcohol consumption after exposure to two types of chronic social stress: intermittent episodes vs. continuous exposure in C57BL/6J mice with a history of drinking
RationaleThe attraction to alcohol can be greatly increased when it is consumed in a social context. While pro-social interactions can potentiate...
-
Histone Methyltransferase G9a Plays an Essential Role on Nicotine Preference in Zebrafish
Psychostimulants regulate behavioral responses in zebrafish via epigenetic mechanisms. We have previously shown that DNA methylation and histone...
-
Changes in Sociability and Preference for Social Novelty in Female Rats in Prolonged Social Isolation
Chronic stress due to social isolation (SI) can lead to distress with negative consequences for both humans and animals. Numerous disorders caused by...
-
Detrimental Effects of Alcohol-Induced Inflammation on Brain Health: From Neurogenesis to Neurodegeneration
AbstractAlcohol consumption is known to cause several brain anomalies. The pathophysiological changes associated with alcohol intoxication are...
-
The ad-libitum taste test as measure of momentary alcohol use in the laboratory: an investigation of construct validity and confounding factors
RationaleThe ad-libitum taste test is a widely used covert measure of motivation to consume alcohol in the laboratory. However, studies on its...
-
Does alcohol automatically capture drinkers’ attention? Exploration through an eye-tracking saccadic choice task
RationaleDominant theoretical models postulate the presence of an automatic attentional bias (AB) towards alcohol-related stimuli in alcohol use...
-
Alcohol-induced damage to the fimbria/fornix reduces hippocampal-prefrontal cortex connection during early abstinence
IntroductionAlcohol dependence is characterized by a gradual reduction in cognitive control and inflexibility to contingency changes. The...
