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1. The Inflammasome Methods and Protocols

   This volume provides inflammasome instructions and tips to study different aspects of inflammasome biology. Chapters guide readers through how to...

   Ali A. Abdul-Sater in Methods in Molecular Biology

   Book 2022
   

2. Mechanistic insights from inflammasome structures

   Inflammasomes are supramolecular complexes that form in the cytosol in response to pathogen-associated and damage-associated stimuli, as well as...

   Jianing Fu, Kate Schroder, Hao Wu in Nature Reviews Immunology

   Article 19 February 2024
   

3. Atranorin inhibits NLRP3 inflammasome activation by targeting ASC and protects NLRP3 inflammasome-driven diseases

   Aberrant NLRP3 activation has been implicated in the pathogenesis of numerous inflammation-associated diseases. However, no small molecular inhibitor...

   Hao-yu Wang, ** Lin, ... Wei Tang in Acta Pharmacologica Sinica

   Article 24 March 2023
   

4. VCP Inhibition Augments NLRP3 Inflammasome Activation

   Lysosomal membrane permeabilization caused either via phagocytosis of particulates or the uptake of protein aggregates can trigger the activation of...

   Ankita Sharma, Dhruva D. Dhavale, ... Conrad C. Weihl in Inflammation

   Article 02 April 2024
   

5. Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets

   Diseases associated with chronic inflammation constitute a major health burden across the world. As central instigators of the inflammatory response...

   Lieselotte Vande Walle, Mohamed Lamkanfi in Nature Reviews Drug Discovery

   Article 29 November 2023
   

6. Structuring Inflammasome-Epigenome: Phenotypic Axis in Gynecological Cancers

   Inflammasomes are made up of sensor proteins, caspase domain having adaptor protein, and caspase-1 aka pro-inflammatory caspase present in the...

   Shivani Sharda, Anupama Avasthi, Navkiran Kaur in Handbook of Oncobiology: From Basic to Clinical Sciences

   Reference work entry 2024
   

7. Mitochondrial damage activates the NLRP10 inflammasome

   Upon detecting pathogens or cell stress, several NOD-like receptors (NLRs) form inflammasome complexes with the adapter ASC and caspase-1, inducing...

   Tomasz Próchnicki, Matilde B. Vasconcelos, ... Eicke Latz in Nature Immunology

   Article 20 March 2023
   

8. Integrated NLRP3, AIM2, NLRC4, Pyrin inflammasome activation and assembly drive PANoptosis

   Inflammasomes are important sentinels of innate immune defense; they sense pathogens and induce the cell death of infected cells, playing key roles...

   SuHyeon Oh, Jihye Lee, ... SangJoon Lee in Cellular & Molecular Immunology

   Article 27 November 2023
   

9. NLRP1 inflammasome promotes senescence and senescence-associated secretory phenotype

   Background

   Senescence is a cellular aging-related process triggered by different stresses and characterized by the secretion of various inflammatory...

   Inés Muela-Zarzuela, Juan Miguel Suarez-Rivero, ... Mario D. Cordero in Inflammation Research

   Article Open access 21 June 2024
   

10. New Insights on NLRP3 Inflammasome: Mechanisms of Activation, Inhibition, and Epigenetic Regulation

    Abstract

    Inflammasomes are important modulators of inflammation. Dysregulation of inflammasomes can enhance vulnerability to conditions such as...

    Triveni kodi, Runali Sankhe, ... Anoop Kishore in Journal of Neuroimmune Pharmacology

    Article Open access 29 February 2024
    

11. A Streamlined Method for Detecting Inflammasome-Induced ASC Oligomerization Using Chemical Crosslinking

    The apoptosis-associated speck-like protein containing a caspase activation and recruitment domain (ASC) functions as the integral adaptor protein...

    Sebastian A. Hughes, James E. Vince in Inflammation and Cancer

    Protocol 2023
    

12. Inflammasome functional activities in B lymphocytes

    Studies in animal models and human subjects have shown that, in addition to their implication in innate immunity, inflammasomes also can play a role...

    Man Lun Hsu, Kai Fu Jhuang, Moncef Zouali in Immunologic Research

    Article 23 May 2024
    

13. The Role of Inflammasome in Cancers and Potential Therapeutic Targets

    Inflammasome is a multi-protein complex that govern the maturation of the pro-inflammatory cytokines such as interleukin-1β (IL-1β) and IL-18 in...

    Pooya Farhangnia, Amir Reza Safdarian, Mahzad Akbarpour in Handbook of Cancer and Immunology

    Living reference work entry 2023
    

14. The role of NLRP3 inflammasome in aging and age-related diseases

    The gradual aging of the global population has led to a surge in age-related diseases, which seriously threaten human health. Researchers are...

    Ruikai Liang, **nrui Qi, ... Peng Yu in Immunity & Ageing

    Article Open access 05 February 2024
    

15. cFLIP_S regulates alternative NLRP3 inflammasome activation in human monocytes

    The innate immune responses, including inflammasome activation, are paramount for host defense against pathogen infection. In contrast to canonical...

    Yuhui Gao, Shi Yu, ... Guangxun Meng in Cellular & Molecular Immunology

    Article 17 August 2023
    

16. Elucidating the Role of miRNA in Inflammasome-Mediated Immune Response in Leishmaniasis

    The inflammasome is a cell cytoplasm-localized multimeric protein complex of host defense mechanism which gets activated due to infection in the...

    Ria Bhar, Kuntal Pal, ... Joydeep Paul in Pathobiology of Parasitic Protozoa: Dynamics and Dimensions

    Chapter 2023
    

17. In Vitro Study of TLR4-NLRP3-Inflammasome Activation in Innate Immune Response

    Toll-like receptors (TLRs) are pivotal players in mediating immune responses. TLR4 is the main receptor for LPS, a strong activator of immune cells....

    Letizia Mezzasoma, Carsten B. Schmidt-Weber, Francesca Fallarino in Toll-Like Receptors

    Protocol 2023
    

18. NLRP3 inflammasome in cognitive impairment and pharmacological properties of its inhibitors

    Cognitive impairment is a multifactorial and multi-step pathological process that places a heavy burden on patients and the society....

    Yi Xu, Yanling Yang, ... Jialing Hu in Translational Neurodegeneration

    Article Open access 02 November 2023
    

19. Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation

    Unlike other nucleotide oligomerization domain-like receptors, Nlrp10 lacks a canonical leucine-rich repeat domain, suggesting that it is incapable...

    Dan** Zheng, Gayatree Mohapatra, ... Eran Elinav in Nature Immunology

    Article 20 March 2023
    

20. Inflammasome Activation Mediates Apoptotic and Pyroptotic Death in Astrocytes Under Ischemic Conditions

    Inflammation is a hallmark mechanism of ischemic stroke-induced brain injury. Recent studies have shown that an intracellular multimeric protein...

    Lap Jack Wong, Bernice Woon Li Lee, ... David Y. Fann in NeuroMolecular Medicine

    Article 30 August 2023