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In Vitro and In Vivo Metabolism Studies
Drug metabolism studies play a critical role in the discovery and development of new chemical entities. These studies provide in-depth understanding...
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In vitro to in vivo extrapolation to derive a metabolism factor for estimating the aggregate exposure to salicylic acid after dermal exposure of its esters
As part of the safety assessment of salicylate esters in cosmetics, we developed a metabolism factor based on in vitro to in vivo extrapolation...
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In Vivo, Ex Vivo, and In Vitro Model Systems for Liver Cancer Research
Cancer claims the lives of millions of people worldwide. Liver cancer represents one such form of cancer that has a high incidence with a poor...
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Use of innovative, cross-disciplinary in vitro, in silico and in vivo approaches to characterize the metabolism of chloro-alpha-pyrrolidinovalerophenone (4-Cl-PVP)
Synthetic cathinones constitute a family of new psychoactive substances, the consumption of which is increasingly worldwide. A lack of metabolic...
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In Vitro and In Silico ADME Prediction
Pharmacokinetic issues have been identified as a major cause for the attrition of new chemical entities in drug discovery. High development costs and...
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Tumor Models of Retinoblastoma: In Vivo, Ex Vivo, and In Vitro Models
In the initial simplistic understanding, childhood retinal cancer retinoblastoma is due to the defect in the retinoblastoma gene. However, the deep...
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Impact of therapeutic inhibition of oncogenic cell signaling tyrosine kinase on cell metabolism: in vivo-detectable metabolic biomarkers of inhibition
BackgroundInhibition of kinases is the ever-expanding therapeutic approach to various types of cancer. Typically, assessment of the treatment...
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Pyrroloquinoline quinone drives ATP synthesis in vitro and in vivo and provides retinal ganglion cell neuroprotection
Retinal ganglion cells are highly metabolically active requiring strictly regulated metabolism and functional mitochondria to keep ATP levels in...
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In Vivo, Ex Vivo, and In Vitro Models Systems for Liver Cancer Research
Cancer claims the lives of millions of people worldwide. Liver cancer represents one such form of cancer that has a high incidence with a poor...
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Uridine 5′-Diphospho-glucuronosyltransferase 1A3 (UGT1A3) Prediction of Hepatic Clearance of Organic Anion Transporting Polypeptide 1B3 (OATP1B3) Substrate Telmisartan by Glucuronidation Using In Vitro–In Vivo Extrapolation (IVIVE)
Background and ObjectiveThe prediction of pharmacokinetic parameters for drugs metabolised by cytochrome P450 enzymes has been the subject of active...
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In silico and in vitro metabolism studies of the new synthetic opiate AP-237 (bucinnazine) using bioinformatics tools
The recent emergence of new synthetic opioids (NSOs) compounds in the illicit market is increasingly related to fatal cases. Identification and...
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Skeletal Muscle Satellite Cell Physiology and Function: Complimentary In Vitro and In Vivo Models and Methods
Skeletal muscle is a highly adaptable tissue, displaying features of hypertrophy (growth) and atrophy (loss), as a result of both internal and...
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In vitro models to detect in vivo bile acid changes induced by antibiotics
Bile acid homeostasis plays an important role in many biological activities through the bile–liver–gut axis. In this study, two in vitro models were...
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QbD-driven development of phospholipid-embedded lipidic nanocarriers of raloxifene: extensive in vitro and in vivo evaluation studies
Raloxifene (RLX) is popularly indicated in treatment of osteoporosis and prevention of breast cancer. Owing to its poor aqueous solubility, high...
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Mouse organoids as an in vitro tool to study the in vivo intestinal response to cytotoxicants
Cross-species comparison of drug responses at the organoid level could help to determine the human relevance of findings from animal studies. To this...
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β-hydroxybutyrate resensitizes colorectal cancer cells to oxaliplatin by suppressing H3K79 methylation in vitro and in vivo
BackgroundKetone β-hydroxybutyrate (BHB) has been reported to prevent tumor cell proliferation and improve drug resistance. However, the...
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An expedited screening platform for the discovery of anti-ageing compounds in vitro and in vivo
BackgroundRestraining or slowing ageing hallmarks at the cellular level have been proposed as a route to increased organismal lifespan and...
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Gut microbiota response to in vitro transit time variation is mediated by microbial growth rates, nutrient use efficiency and adaptation to in vivo transit time
BackgroundTransit time is an important modulator of the human gut microbiome. The inability to modify transit time as the sole variable hampers...
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Mirtazapine loaded polymeric micelles for rapid release tablet: A novel formulation—In vitro and in vivo studies
Major depression is a prevalent disorder characterized by sadness, lack of interest or pleasure, interrupted sleep or food, and impaired...
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Preclinical Pharmacokinetics and in vitro Metabolism of FHND5071, a Novel Selective RET Kinase Inhibitor
Background and ObjectivesRearranged during transfection (RET) is a transmembrane receptor tyrosine kinase that plays a crucial role in tumorigenesis....
