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Dissolution Kinetics of Nifedipine—Ionizable Polymer Amorphous Solid Dispersion: Comparison Between Bicarbonate and Phosphate Buffers
PurposeThe intestinal fluid pH is maintained by the bicarbonate buffer system that shows unique properties regarding drug dissolution. Nevertheless,...
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Impact of Processing Methods on the Physico-chemical Properties of Posaconazole Amorphous Solid Dispersions
Background & PurposeDifferent methods have been exploited to generate amorphous solid dispersions (ASDs) of poorly water-soluble drugs. However, the...
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ASD Formation Prior to Material Characterization as Key Parameter for Accurate Measurements and Subsequent Process Simulation for Hot-Melt Extrusion
Process simulation facilitates scale-up of hot-melt extrusion (HME) and enhances proper understanding of the underlying critical process parameters....
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Influence of Particle Size and Drug Load on Amorphous Solid Dispersions Containing pH-Dependent Soluble Polymers and the Weak Base Ketoconazole
Among the great number of poorly soluble drugs in pharmaceutical development, most of them are weak bases. Typically, they readily dissolve in an...
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Precipitation Technologies for Nanoparticle Production
Precipitation technologies have been widely studied for nanoparticle production because they provide more control over particle size, shape, and...
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Third Generation Solid Dispersion-Based Formulation of Novel Anti-Tubercular Agent Exhibited Improvement in Solubility, Dissolution and Biological Activity
The long treatment period and development of drug resistance in tuberculosis (TB) necessitates the discovery of new anti-tubercular agents. The drug...
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Multivariate Analysis of Solubility Parameters for Drug-Polymer Miscibility Assessment in Preparing Raloxifene Hydrochloride Amorphous Solid Dispersions
The success of obtaining solid dispersions for solubility improvement invariably depends on the miscibility of the drug and polymeric carriers. This...
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Machine Learning in Additive Manufacturing of Pharmaceuticals
The application of machine learning and deep learning in additive manufacturing, also called 3D printing, is expected in industrial fields to be an...
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Advancements of hot-melt extrusion technology to address unmet patient needs and pharmaceutical quality aspects
BackgroundHot-melt extrusion (HME) significantly affects pharmaceutical manufacturing by enhancing drug solubility and bioavailability. Advancements...
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Flux-Based Formulation Development—A Proof of Concept Study
The work aimed to develop the Absorption Driven Drug Formulation (ADDF) concept, which is a new approach in formulation development to ensure that...
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Identification of a Multi-Component Formulation for Intestinal Delivery of a GLP-1/Glucagon Co-agonist Peptide
PurposeOral delivery of therapeutic peptides has been challenging due to multiple physiological factors and physicochemical properties of peptides....
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Preparation and Characterization of Ibrutinib Amorphous Solid Dispersions: a Discussion of Interaction Force
The aim of this study was to improve the solubility and dissolution of Ibrutinib (IBR), a biopharmaceutical classification system (BCS) class II...
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Application of Liquisolid Pellets Technology for Improving Dissolution of Posaconazole: A DoE Based Process Optimization
PurposePosaconazole (PSZ) is BCS class-II drug that displays variable bioavailability upon oral administration due to extremely low and pH-dependent...
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Continuous Manufacturing and Molecular Modeling of Pharmaceutical Amorphous Solid Dispersions
Amorphous solid dispersions enhance solubility and oral bioavailability of poorly water-soluble drugs. The escalating number of drugs with poor...
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Therapeutic Polymer Conjugates and Their Characterization
Drugs, proteins, and nanoparticles delivered into the body are exposed to numerous mechanisms for premature elimination and deterioration within the...
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The Development of a Novel Pharmaceutical Formulation of D-Tagatose for Spray-Drying
PurposeD-tagatose is an alternative sweetener with superior properties for reducing overall sugar absorption, which is especially important in the...
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Application of Insoluble Excipients in Solid Dispersion of Chinese Medicines
In recent years, as the great success of arteannuin in the area of antimalarial treatment and commercial benefit, traditional Chinese medicine (TCM)...
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Combination of co-crystal and nanocrystal techniques to improve the solubility and dissolution rate of poorly soluble drugs
PurposeSolubility and dissolution rate are essential for the oral absorption and bioavailability of poorly soluble drugs. The aim of this study was...
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Osmolality of Excipients for Parenteral Formulation Measured by Freezing Point Depression and Vapor Pressure – A Comparative Analysis
PurposeTo investigate the difference in methods to determine the osmolality in solutions of stabilizers used for long-acting injectable suspensions.
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Impact of Surfactants on the Performance of Clopidogrel-Copovidone Amorphous Solid Dispersions: Increased Drug Loading and Stabilization of Nanodroplets
PurposeSurfactants are increasingly being added to amorphous solid dispersion (ASDs) formulations to enhance processability and release performance....
