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Case Study 11: Considerations for Enzyme Map** Experiments—Interaction Between the Aldehyde Oxidase Inhibitor Hydralazine and Glutathione
Often it may be convenient and efficient to address multiple research questions with a single experiment. In many instances, however, the best...
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Role of Pharmacogenomics in Reducing the Risk of Drug-Related Iatrogenesis
Purpose of ReviewDrug-related iatrogenesis includes medication errors, adverse drug events, and adverse drug reactions and is among the most...
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Simvastatin therapy attenuates memory deficits that associate with brain monocyte infiltration in chronic hypercholesterolemia
Evidence associates cardiovascular risk factors with unfavorable systemic and neuro-inflammation and cognitive decline in the elderly. Cardiovascular...
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Drugs Used in Heart Failure
Congestive heart failure (CHF) is a systolic dysfunction of the heart in which the pum** efficiency or ejection fraction reduces and the body...
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Novel Multiplexed High Throughput Screening of Selective Inhibitors for Drug-Metabolizing Enzymes Using Human Hepatocytes
Selective chemical inhibitors are critical for reaction phenoty** to identify drug-metabolizing enzymes that are involved in the elimination of...
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Acrolein Aggravates Secondary Brain Injury After Intracerebral Hemorrhage Through Drp1-Mediated Mitochondrial Oxidative Damage in Mice
Clinical advances in the treatment of intracranial hemorrhage (ICH) are restricted by the incomplete understanding of the molecular mechanisms...
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Characterization of Divergent Metabolic Pathways in Elucidating an Unexpected, Slow-Forming, and Long Half-Life Major Metabolite of Iclepertin
PurposeAfter single oral dosing of the glycine reuptake transporter (GlyT1) inhibitor, iclepertin (BI 425809), a single major circulating metabolite,...
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Drugs Acting on Renal and Cardiovascular Function
Cardiovascular medications play a crucial role in medical practice by influencing the functionality of the heart and blood vessels. These medications...
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Pharmacogenomics Informs Cardiovascular Pharmacotherapy
Precision medicine exemplifies the emergence of personalized treatment options which may benefit specific patient populations based upon their...
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Clinical trials of new drugs for Alzheimer disease: a 2020–2023 update
Alzheimer's disease (AD) is the leading cause of dementia, presenting a significant unmet medical need worldwide. The pathogenesis of AD involves...
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Epigenetic regulation of major histocompatibility complexes in gastrointestinal malignancies and the potential for clinical interception
BackgroundGastrointestinal malignancies encompass a diverse group of cancers that pose significant challenges to global health. The major...
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N-acetyltransferase 2 acetylator genotype-dependent N-acetylation and toxicity of the arylamine carcinogen β-naphthylamine in cryopreserved human hepatocytes
We used cryopreserved human hepatocytes that express rapid, intermediate, and slow acetylator N -acetyltransferase 2 (NAT2) genotypes to measure the N -...
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Mechanisms of vascular damage in ANCA vasculitis
The discovery of anti-neutrophil cytoplasmic antibodies (ANCA) and their antigenic targets, myeloperoxidase (MPO) and proteinase 3 (PR3), has led to...
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Renin Angiotensin System Inhibitors in Heart Failure with Reduced Ejection Fraction: Clinical Evidence and Considerations for Use
The renin angiotensin systemRenin angiotensin system (RAS) plays an important role in the regulation of body fluids and blood pressure. Therapy with...