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Spatial multi-omics at subcellular resolution via high-throughput in situ pairwise sequencing
Technology for spatial multi-omics aids the discovery of new insights into cellular functions and disease mechanisms. Here we report the development...
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Computational Pipeline for the Detection of Plant RNA Viruses Using High-Throughput Sequencing
In this chapter, we describe a computational pipeline for the in silico detection of plant viruses by high-throughput sequencing (HTS) from total RNA...
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Viromes of Plants Determined by High-Throughput Sequencing of Virus-Derived siRNAs
Plants growing in open airfields can be infected by several viruses even as a multiple infection. Virus infection in crops can lead to a serious...
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High-throughput sequencing reveals Jatrorrhizine inhibits colorectal cancer growth by ferroptosis-related genes
BackgroundColorectal cancer is a malignant tumor that poses a serious threat to human health. The main objective of this study is to investigate the...
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Validation of High-Throughput Sequencing (HTS) for Routine Detection of Citrus Viruses and Viroids
The management of plant diseases relies on the accurate identification of pathogens that requires a robust and validated tool in terms of...
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EGFR-Activated JAK2/STAT3 Pathway Confers Neuroprotection in Spinal Cord Ischemia–Reperfusion Injury: Evidence from High-Throughput Sequencing and Experimental Models
This study aimed to investigate the molecular mechanisms underlying spinal cord ischemia–reperfusion (SCI/R) injury. Through RNA-Seq high-throughput...
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Deciphering the virome of Chunkung (Cnidium officinale) showing dwarfism-like symptoms via a high-throughput sequencing analysis
BackgroundViruses have notable effects on agroecosystems, wherein they can adversely affect plant health and cause problems (e.g., increased...
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Exploring the Diversity of the B-Cell Receptor Repertoire Through High-Throughput Sequencing
Repertoire sequencing of B cells is the high-throughput profiling of B cell receptors (BCR) expressed on the surface of B cells and of...
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High-throughput circular RNA sequencing reveals the profiles of circular RNA in non-cirrhotic hepatocellular carcinoma
BackgroundLiver cirrhosis is a well-known risk factor for hepatocellular carcinoma (HCC). However, some HCC cases can also originate from...
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High-Throughput Screening to Identify Modulators of Sarcospan
High-throughput screening enables the discovery of disease-modifying small molecules. Here, we describe the development of a scalable, cell-based...
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MicroRNA expression profiling of cerebrospinal fluid/serum exosomes in children with human herpesvirus 6-associated encephalitis/encephalopathy by high-throughput sequencing
Primary human herpesvirus 6 (HHV-6) infection is sometimes accompanied by acute encephalopathy with reduced subcortical diffusion (AED) in...
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High-Throughput Combined Analysis of Saliva Microbiota and Metabolomic Profile in Chinese Periodontitis Patients: A Pilot Study
The onset and progression of periodontitis involves complicated interactions between the dysbiotic oral microbiota and disrupted host...
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Omic-Based Biomarkers Discovery in Alzheimer’s Disease: High-Throughput Approaches
The discovery of novel metabolomic, proteomic, lipidomic, and transcriptomic (mRNA and miRNA) biomarkers in serum, plasma, brain, and CSF is a...
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Omic-Based Biomarkers Discovery in Alzheimer’s Disease: High-Throughput Approaches
The discovery of novel metabolomic, proteomic, lipidomic, and transcriptomic (mRNA and miRNA) biomarkers in serum, plasma, brain, and CSF is a...
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High-throughput biochemistry in RNA sequence space: predicting structure and function
RNAs are central to fundamental biological processes in all known organisms. The set of possible intramolecular interactions of RNA nucleotides...
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Evaluation of exosomal non-coding RNAs in cancer using high-throughput sequencing
Clinical oncologists need more reliable and non-invasive diagnostic and prognostic biomarkers to follow-up cancer patients. However, the existing...
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Next-Generation Sequencing
The next-generation sequencing platforms can generate a large amount of high-throughput sequencing data in a short span of time. Reference-based...
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Isolation of high-quality RNA for high throughput applications from secondary metabolite-rich Crocus sativus L.
ObjectiveIsolating high-quality RNA is a basic requirement while performing high throughput sequencing, microarray, and various other molecular...
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Identification of druggable regulators of cell secretion via a kinome-wide screen and high-throughput immunomagnetic cell sorting
The identification of genetic regulators of cell secretions is challenging because it requires the sorting of a large number of cells according to...
