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High-Throughput Screening to Identify Modulators of Sarcospan
High-throughput screening enables the discovery of disease-modifying small molecules. Here, we describe the development of a scalable, cell-based...
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High-Throughput Screening Assays in Toxicology
This second edition volume expands on the previous edition by exploring the latest advancements in high throughput screening (HTS) in toxicity...
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Fluorescence-Based Peptidolytic Assay for High-Throughput Screening of MMP14 Inhibitors
The membrane-bound matrix metalloproteinase 14 (MMP14, also known as MT1-MMP) plays important roles in the remodeling of the extracellular matrix...
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Novel Multiplexed High Throughput Screening of Selective Inhibitors for Drug-Metabolizing Enzymes Using Human Hepatocytes
Selective chemical inhibitors are critical for reaction phenoty** to identify drug-metabolizing enzymes that are involved in the elimination of...
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A high-throughput screening system for SARS-CoV-2 entry inhibition, syncytia formation and cell toxicity
BackgroundThe entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the host cell is mediated through the binding of the...
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Peptide-encoding mRNA barcodes for the high-throughput in vivo screening of libraries of lipid nanoparticles for mRNA delivery
Develo** safe and effective nanoparticles for the delivery of messenger RNA (mRNA) is slow and expensive, partly due to the lack of predictive...
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Exploring Allosteric Inhibitors of Protein Tyrosine Phosphatases Through High-Throughput Screening
High-throughput screening (HTS) using a natural or synthetic chemical or natural product library is a powerful technique for discovering novel...
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High-throughput screening of genetic and cellular drivers of syncytium formation induced by the spike protein of SARS-CoV-2
Map** mutations and discovering cellular determinants that cause the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)...
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A high-throughput screening assay to identify inhibitory antibodies targeting alphavirus release
BackgroundSeveral studies have demonstrated neutralizing antibodies to be highly effective against alphavirus infection in animal models, both...
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Acetylcholinesterase Inhibition Assays for High-Throughput Screening
Acetylcholinesterase (AChE) hydrolyzes acetylcholine (ACh), a vital neurotransmitter that regulates muscle movement and brain function, including...
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A Quantitative High-Throughput Screening Data Analysis Pipeline for Activity Profiling
The U.S. Tox21Tox21 program has developed in vitro assaysIn vitro assays to test large collections of environmental chemicals in a quantitative...
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A Dual-Readout High-Throughput Screening Assay for Small Molecules Active Against Aspergillus Fumigatus
Human fungal infections caused by molds have been on the rise in recent years. These infections have high mortality rates compared to other fungal...
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Development of an in chemico high-throughput screening method for the identification of skin sensitization potential
It is well established that chemical-peptide conjugation represents the molecular initiating event (MIE) in skin sensitization. This MIE has been...
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A NF-κB-Based High-Throughput Screening for Immune Adjuvants and Inhibitors
The nuclear factor-κB (NF-κB) family is crucial for regulating immune and inflammatory responses. The activation of the immune cell signaling pathway...
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High-Throughput Screening Assay Profiling for Large Chemical Databases
High-throughput screening (HTS) techniques are increasingly being adopted by a variety of fields of toxicology. Notably, large-scale research efforts...
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3D Hydrogel Cultures for High-Throughput Drug Discovery
Our increased understanding of how a cell’s microenvironment influences its behavior has fueled an interest in three-dimensional (3D) cell cultures...
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A high-throughput screening campaign against PFKFB3 identified potential inhibitors with novel scaffolds
The growth of solid tumors depends on tumor vascularization and the endothelial cells (ECs) that line the lumen of blood vessels. ECs generate a...
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Optogenetic and High-Throughput Drug Discovery
Optogenetics, a technique based on natural or genetically engineered light-sensitive proteins, combines genetic manipulation and optics offering...
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A 384-Well Microtiter Plate Model for Candida Biofilm Formation and Its Application to High-Throughput Screening
Candidiasis, infections caused by Candida spp., represents one of the most common nosocomial infections afflicting an expanding number of compromised...
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MAC-Seq: Coupling Low-Cost, High-Throughput RNA-Seq with Image-Based Phenotypic Screening in 2D and 3D Cell Models
Transcriptomic profiling has fundamentally influenced our understanding of cancer pathophysiology and response to therapeutic intervention and has...