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An Understanding of the Relationship Between Mixing Performance and Power Consumption in a High-Shear Wet Granulation Pre-mixing
IntroductionHigh-shear wet granulation (HSWG) is most commonly used in the pharmaceutical industry, with the advantages of being fully enclosed,...
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Application of Twin-Screw Melt Granulation to Overcome the Poor Tabletability of a High Dose Drug
Pharmaceutical tablet manufacturing has seen a paradigm shift toward continuous manufacturing and twin-screw granulation-based technologies have...
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An Evaluation of Wet Granulation Process Selection for API Prone to Polymorphic Form Conversion in the Presence of Moisture and Heat
PurposeWet granulation (WG) is one of the most versatile processes to improve blend properties for processing. However, due to its need for moisture...
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Effect of Manufacturing Conditions on Particle Characteristics in the Drug-Layering Process of a Novel Melt Granulation Technology, MALCORE®, Using a Design of Experiments
PurposeMALCORE ® , a manufacturing technology of drug-containing particles (DCPs) for coating, consists of a 2-step melt granulation process. The...
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Polymer Characteristics for Drug Layering on Particles Using a Novel Melt Granulation Technology, MALCORE®
MALCORE ® , a novel manufacturing technology for drug-containing particles (DCPs), relies on the melt granulation method to produce spherical particles...
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Metamorphosis of Twin Screw Extruder-Based Granulation Technology: Applications Focusing on Its Impact on Conventional Granulation Technology
In order to be at pace with the market requirements of solid dosage forms and regulatory standards, a transformation towards systematic processing...
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Development of prediction model with machine learning in continuous twin screw granulation
PurposeThis study aimed to use machine learning to predict the quality of a drug product prepared through continuous manufacturing.
Methods ...
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QbD-Guided Traditional Chinese Medicine Manufacturing Process: Development and Optimization of Fluid-Bed Granulation and Drying Processes for **aochaihu Capsules
Traditional methods of producing **aochaihu (XCH) capsules, a traditional Chinese medicine, are time-consuming, costly, and labor-intensive, which is...
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Assessment of Abrasion-Induced Visual Defects in Twin Screw Wet Granulation Using Wall Friction Measurements
Starting point of the presented study were abrasion effects occurring during a twin screw wet granulation (TSG) process of a new chemical entity...
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Twin Screw Melt Granulation: Alternative Approach for Improving Solubility and Permeability of a Non-steroidal Anti-inflammatory Drug Ibuprofen
The current research is focused on investigating the suitability of the twin screw melt granulation (TSMG) approach for improving the solubility of a...
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Risk Assessment for a Twin-Screw Granulation Process Using a Supervised Physics-Constrained Auto-encoder and Support Vector Machine Framework
Quality risk management is an important task when it pertains to the pharmaceutical industry, as this is directly related to product performance....
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Impact of Properties of Hydrated Silicon Dioxide as Core Material on the Characteristics of Drug-containing Particles Prepared by the 2-step Process Melt Granulation Technology, MALCORE®
Drug-containing particles (DCPs) are frequently used as cores in the development of solid oral dosage forms. The wet layering technique, which is a...
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The Effect of Process Variables and Binder Concentration on Tabletability of Metformin Hydrochloride and Acetaminophen Granules Produced by Twin Screw Melt Granulation with Different Polymeric Binders
In twin screw melt granulation, granules are produced by passing mixtures of drug substances and polymeric binders through twin screw extruder such...
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Immediate-Release Formulations Produced via Twin-Screw Melt Granulation: Systematic Evaluation of the Addition of Disintegrants
The current study evaluated the effect of location and amount of various superdisintegrants on the properties of tablets made by twin-screw melt...
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Artificial Neural Network and Support Vector Regression Modeling for Prediction of Mixing Time in Wet Granulation
PurposeEvery successful pharmaceutical product requires a rapid and reliable scale-up process from small laboratory quantities to a large commercial...
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Continuous Wet Granulation
Wet granulation is a critical unit operation in solid dosage form manufacturing in the pharmaceutical industry. Traditionally, wet granulation has...
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Effects of Formulation and Manufacturing Process on Drug Release from Solid Self-emulsifying Drug Delivery Systems Prepared by High Shear Mixing
This study sought to investigate the influence of formulation and process factors of the high shear mixing (HSM) on the properties of solid...
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Tablet Quality-Prediction Model Using Quality Material Attributes: Toward Flexible Switching Between Batch and Continuous Granulation
PurposeThe purpose of the study was to develop a model to predict the critical quality attribute (CQA) of tablets during continuous and batch...
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Rapid Mixer Granulator
For manufacturing solid oral dosage forms, such as tablets and capsules, good flow of granules is crucial. Granulation of poorly flowable powder can...
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Effect of Hydroxypropyl Cellulose Level on Twin-Screw Melt Granulation of Acetaminophen
This study investigated the effect of binder level on the physicochemical changes and tabletability of acetaminophen (APAP)-hydroxypropyl cellulose...
