Search
Search Results
-
ACE2 Expressed on Myeloid Cells Alleviates Sepsis-Induced Acute Liver Injury via the Ang-(1–7)–Mas Receptor Axis
Sepsis-induced acute liver injury (ALI) is common in intensive care units. Angiotensin-converting enzyme 2 (ACE2) plays a vital role in hepatic...
-
MiR-17-5p Mediates the Effects of ACE2-Enriched Endothelial Progenitor Cell-Derived Exosomes on Ameliorating Cerebral Ischemic Injury in Aged Mice
Aging is one of the key mechanisms of vascular dysfunction and contributes to the initiation and progression of ischemic stroke (IS). Our previous...
-
SARS-CoV-2 receptor binding domain radio-probe: a non-invasive approach for angiotensin-converting enzyme 2 map** in mice
The spike protein of SARS-CoV-2 interacts with angiotensin-converting enzyme 2 (ACE2) of human respiratory epithelial cells, which leads to...
-
Effect of exercise duration on toluene-induced locomotor sensitization in mice: a focus on the Renin Angiotensin System
RationaleExercise attenuates addictive behavior; however, little is known about the contribution of exercise duration to this positive effect. The...
-
Diminazene aceturate mitigates cardiomyopathy by interfering with renin-angiotensin system in a septic rat model
BackgroundThere were limited studies investigating treatments of septic cardiomyopathy (SCM), which is a common complication during sepsis. A septic...
-
Epigenetic targeting of the ACE2 and NRP1 viral receptors limits SARS-CoV-2 infectivity
BackgroundSARS-CoV-2 uses the angiotensin-converting enzyme 2 (ACE2) and neuropilin-1 (NRP1) receptors for entry into cells, and the serine protease...
-
The Actin Bundling Protein Fascin-1 as an ACE2-Accessory Protein
We have previously shown that angiotensin-converting enzyme 2 (ACE2), an enzyme counterbalancing the deleterious effects of angiotensin type 1...
-
Protective effect of recombinant Lactobacillus plantarum against H2O2-induced oxidative stress in HUVEC cells
This study probed the protective effect of recombinant Lactobacillus plantarum against hydrogen peroxide (H 2 O 2 )-induced oxidative stress in human...
-
Techniques for Develo** Reliable Machine Learning Classifiers Applied to Understanding and Predicting Protein:Protein Interaction Hot Spots
With machine learning now transforming the sciences, successful prediction of biological structure or activity is mainly limited by the extent and...
-
In Vitro and in Vivo Evaluation Tools of SARS-CoV-2 Antiviral Drugs
We have outlined the in vitro and preclinical methods for the assessment of the therapeutic properties of compounds against SARS-CoV2 in this...
-
Correlation Between Renin Angiotensin System and Infectious Disease
The renin- angiotensin system (RAS) is a physiological system that through a cascade of mediators and different mechanisms is able to regulate...
-
Metabolomics Approach in Differentiating RAS Responses in ARDS and SAR-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes host angiotensin converting enzyme 2 (ACE2) for viral entry. This interaction...
-
Emerging Contributions of Endocrine Pathophysiology in Virus-Related Infectious Disease: Focus on the RAAS in COVID-19 and HIV
Aside from its traditional role in maintaining vascular hemodynamics and sodium balance, the renin–angiotensin–aldosterone system (RAAS) is...
-
Insights on Various Antiviral Drugs for Treating Patients with COVID-19
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was the cause of the first pandemic of the twenty-first century, which began in...
-
Essentials in saline pharmacology for nasal or respiratory hygiene in times of COVID-19
PurposeNasal irrigation or nebulizing aerosol of isotonic or hypertonic saline is a traditional method for respiratory or nasal care. A recent small...
-
Cardiovascular Protective Arm of Renin Angiotensin System
Cardiovascular protective axis of Renin Angiotensin SystemRenin angiotensin system is relatively newer concept and largely originated from the...
-
The Renin Angiotensin System at the Time of COVID-19
The renin angiotensin system RASRenin angiotensin system is one of the most complex regulatory circuits in our body, e.g. responsible for the...
-
Serum Angiotensin II as a Biomarker in COVID-19
Angiotensin II, synthesized by the cleavage of angiotensinogen to angiotensin I by renin and then conversion to angiotensin II by the...
-
COVID-19-Induced Kidney Disease: Ethnopharmacological Intervention to Ameliorate Kidney Damage and Improve Kidney Function
The coronavirus disease 2019 (COVID-19) pandemic has left a trail of disaster in its wake. Not only has it resulted in a large-scale loss of life,...
-
Role of Renin-Angiotensin System in the Pathogenesis and Progression of Non-alcoholic Fatty Liver
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver diseases and is increasing simultaneously with obesity and Type 2...