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Reduced glutathione level in the aqueous humor of patients with primary open-angle glaucoma and normal-tension glaucoma
Glaucoma is a leading cause of blindness worldwide in older people. Profiling the aqueous humor, including the metabolites it contains, is useful to...
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Glaucoma-TrEl: A web-based interactive database to build evidence-based hypotheses on the role of trace elements in glaucoma
ObjectiveGlaucoma is a chronic neurological disease that is associated with high intraocular pressure (IOP), causes gradual damage to retinal...
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Ventriculoperitoneal shunt patients and glaucoma: a cohort analysis of the NPH registry
BackgroundIdiopathic Normal Pressure Hydrocephalus (iNPH) is a chronic condition affecting the elderly. It is characterized by a triad of symptoms...
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Regulated Necrosis in Glaucoma: Focus on Ferroptosis and Pyroptosis
Glaucoma is one of the most common causes of irreversible blindness worldwide. This neurodegenerative disease is characterized by progressive and...
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Advances in Neuroprotective Mechanisms of Aerobic Exercise to Reduce the Risk of Glaucoma
PurposeGlaucoma is the leading cause of irreversible blindness worldwide and remains a worldwide problem. Epidemiological studies have shown that...
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Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci
Glaucoma, a leading cause of irreversible blindness, is a highly heritable human disease. Previous genome-wide association studies have identified...
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Polygenic risk score-based phenome-wide association for glaucoma and its impact on disease susceptibility in two large biobanks
BackgroundGlaucoma is a leading cause of worldwide irreversible blindness. Considerable uncertainty remains regarding the association between a...
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Perspectives on Adherence to Glaucoma Medical Therapy in Brazilian Patients
BackgroundPoor adherence to glaucoma medication regimens may be associated with subsequent optic nerve damage and irreversible visual loss. Specific...
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Tau modulation through AAV9 therapy augments Akt/Erk survival signalling in glaucoma mitigating the retinal degenerative phenotype
The microtubule-associated protein Tau is a key player in various neurodegenerative conditions, including Alzheimer's disease (AD) and Tauopathies,...
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Th1 cells contribute to retinal ganglion cell loss in glaucoma in a VCAM-1-dependent manner
Glaucoma is a complex neurodegenerative disorder characterized by the progressive loss of retinal ganglion cells (RGC) and optic nerve axons, leading...
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Regulated Cell Death of Retinal Ganglion Cells in Glaucoma: Molecular Insights and Therapeutic Potentials
Glaucoma is a group of diseases characterized by the degeneration of retinal ganglion cells (RGCs) and progressive, irreversible vision loss. High...
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Identification and validation of autophagy-related genes in primary open-angle glaucoma
BackgroundAs the most common type of glaucoma, the etiology of primary open-angle glaucoma (POAG) has not been unified. Autophagy may affect the...
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cFLIP in the molecular regulation of astroglia-driven neuroinflammation in experimental glaucoma
BackgroundRecent experimental studies of neuroinflammation in glaucoma pointed to cFLIP as a molecular switch for cell fate decisions, mainly...
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Loss of Sarm1 reduces retinal ganglion cell loss in chronic glaucoma
Glaucoma is one of the leading causes of irreversible blindness worldwide and vision loss in the disease results from the deterioration of retinal...
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Manufacturing and characterisation of 3D-printed sustained-release Timolol implants for glaucoma treatment
Timolol maleate (TML) is a beta-blocker drug that is commonly used to lower the intraocular pressure in glaucoma. This study focused on using a 3D...
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Aqueous Humor Circulation in the Era of Minimally Invasive Surgery for Glaucoma
Glaucoma surgery with implantation of aqueous humor draining microstents may compromise long-term corneal health by disrupting aqueous humor...
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NRF2/ARE mediated antioxidant response to glaucoma: role of glia and retinal ganglion cells
Glaucoma, the second leading cause of irreversible blindness worldwide, is associated with age and sensitivity to intraocular pressure (IOP). We have...
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The correlation between primary open-angle glaucoma (POAG) and gut microbiota: a pilot study towards predictive, preventive, and personalized medicine
BackgroundGlaucoma is the leading cause of irreversible blindness worldwide. Emerged evidence has shown that glaucoma is considered an immune system...
