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Genetic variation across and within individuals
Germline variation and somatic mutation are intricately connected and together shape human traits and disease risks. Germline variants are present...
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Genetic and environmental interactions contribute to immune variation in rewilded mice
The relative and synergistic contributions of genetics and environment to interindividual immune response variation remain unclear, despite...
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Reduced within-population quantitative genetic variation is associated with climate harshness in maritime pine
How evolutionary forces interact to maintain genetic variation within populations has been a matter of extensive theoretical debates. While mutation...
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Genetic variation of morphological scaling in Drosophila melanogaster
Morphological scaling relationships between the sizes of individual traits and the body captures the characteristic shape of a species, and their...
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Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes
Noncoding genetic variation drives phenotypic diversity, but underlying mechanisms and affected cell types are incompletely understood. Here,...
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Cell subtype-specific effects of genetic variation in the Alzheimer’s disease brain
The relationship between genetic variation and gene expression in brain cell types and subtypes remains understudied. Here, we generated...
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Impact of Genetic Variation on Drug Response
Pharmacogenomics investigates the influence of genetics on drug response, with the ultimate aim of giving patients the right drug at the right dose...
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Somatic genetic variation in healthy tissue and non-cancer diseases
Somatic genetic variants have been studied for several years mostly concerning cancer, where they contribute to its origin and development. It is...
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Resolving haplotype variation and complex genetic architecture in the human immunoglobulin kappa chain locus in individuals of diverse ancestry
Immunoglobulins (IGs), critical components of the human immune system, are composed of heavy and light protein chains encoded at three genomic loci....
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Germline genetic variation and predicting immune checkpoint inhibitor induced toxicity
Immune checkpoint inhibitor (ICI) therapy has revolutionised the treatment of various cancer types. ICIs reinstate T-cell function to elicit an...
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Association of disease severity and genetic variation during primary Respiratory Syncytial Virus infections
BackgroundRespiratory Syncytial Virus (RSV) disease in young children ranges from mild cold symptoms to severe symptoms that require hospitalization...
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Contrasts in riverscape patterns of intraspecific genetic variation in a diverse Neotropical fish community of high conservation value
Spatial patterns of genetic variation compared across species provide information about the predictability of genetic diversity in natural...
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HLA Genes: A Hallmark of Functional Genetic Variation and Complex Evolution
The major histocompatibility complex (MHC) with its highly polymorphic HLA genes represents one of the most intensely studied genomic regions in the...
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Characterization of the genetic variation and evolutionary divergence of the CLEC18 family
BackgroundThe C-type lectin family 18 (CLEC18) with lipid and glycan binding capabilities is important to metabolic regulation and innate immune...
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Host genetic variation drives the differentiation in the ecological role of the native Miscanthus root-associated microbiome
BackgroundMicrobiome recruitment is influenced by plant host, but how host plant impacts the assembly, functions, and interactions of perennial plant...
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Genetic variation of the freshwater snail Indoplanorbis exustus (Gastropoda: Planorbidae) in Thailand, inferred from 18S and 28S rDNA sequences
Indoplanorbis exustus , a freshwater pulmonate snail, is widely distributed in tropical and subtropical zones and plays a significant role as an...
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Genetic Variation and Mendelian Randomization Approaches
While genome-wide association studies (GWAS) on levels of nuclear receptors are sparse, the genetics of ligands of these receptors (steroid hormones,...
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Leveraging Mann–Whitney U test on large-scale genetic variation data for analysing malaria genetic markers
BackgroundThe malaria risk analysis of multiple populations is crucial and of great importance whilst compressing limitations. However, the...
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Dietary stress remodels the genetic architecture of lifespan variation in outbred Drosophila
Evolutionary theory suggests that lifespan-reducing alleles should be purged from the gene pool, and yet decades of genome-wide association and model...
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The relationship between extreme inter-individual variation in macrophage gene expression and genetic susceptibility to inflammatory bowel disease
The differentiation of resident intestinal macrophages from blood monocytes depends upon signals from the macrophage colony-stimulating factor...
