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Primary Intestinal Fibroblasts: Isolation, Cultivation, and Maintenance
Intestinal fibroblasts maintain homeostasis and contribute to inflammatory responses and the development of cancer. Intestinal fibroblasts express...
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Metastasis-associated fibroblasts in peritoneal surface malignancies
Over decades, peritoneal surface malignancies (PSMs) have been associated with limited treatment options and poor prognosis. However, advancements in...
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CD200+ fibroblasts form a pro-resolving mesenchymal network in arthritis
Fibroblasts are important regulators of inflammation, but whether fibroblasts change phenotype during resolution of inflammation is not clear. Here...
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Distinct origin and region-dependent contribution of stromal fibroblasts to fibrosis following traumatic injury in mice
Fibrotic scar tissue formation occurs in humans and mice. The fibrotic scar impairs tissue regeneration and functional recovery. However, the origin...
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CD34+ synovial fibroblasts exhibit high osteogenic potential in synovial chondromatosis
Synovial chondromatosis (SC) is a disorder of the synovium characterized by the formation of osteochondral nodules within the synovium. This study...
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CNS tumor stroma transcriptomics identify perivascular fibroblasts as predictors of immunotherapy resistance in glioblastoma patients
Excessive deposition of extracellular matrix (ECM) is a hallmark of solid tumors; however, it remains poorly understood which cellular and molecular...
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In situ reprogramming of cardiac fibroblasts into cardiomyocytes in mouse heart with chemicals
Cardiomyocytes are terminal differentiated cells and have limited ability to proliferate or regenerate. Condition like myocardial infarction causes...
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Loss of SPRY2 contributes to cancer-associated fibroblasts activation and promotes breast cancer development
The communication between tumor cells and tumor microenvironment plays a critical role in cancer development. Cancer-associated fibroblasts (CAFs)...
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Transgene-free direct conversion of murine fibroblasts into functional muscle stem cells
Transcription factor-based cellular reprogramming provides an attractive approach to produce desired cell types for regenerative medicine purposes....
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Cancer-associated fibroblasts: a versatile mediator in tumor progression, metastasis, and targeted therapy
Tumor microenvironment (TME) has been demonstrated to play a significant role in tumor initiation, progression, and metastasis. Cancer-associated...
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IRAK-M Regulates Proliferative and Invasive Phenotypes of Lung Fibroblasts
Lung fibroblasts play an important role in subepithelial fibrosis, one feature for airway remodeling. IL-1 receptor-associated kinase (IRAK)-M was...
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Mitochondrial alterations in fibroblasts from sporadic Alzheimer's disease (AD) patients correlate with AD-related clinical hallmarks
Mitochondrial dysfunctions are key features of Alzheimer’s disease (AD). The occurrence of these disturbances in the peripheral cells of AD patients...
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Cancer-associated fibroblasts: from basic science to anticancer therapy
Cancer-associated fibroblasts (CAFs), as a central component of the tumor microenvironment in primary and metastatic tumors, profoundly influence the...
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A new physiological medium uncovers biochemical and cellular alterations in Lesch-Nyhan disease fibroblasts
BackgroundLesch-Nyhan disease (LND) is a severe neurological disorder caused by the genetic deficiency of hypoxanthine–guanine...
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Isolation of Normal and Cancer-Associated Fibroblasts
Cancer-associated fibroblasts (CAFs) play important roles in regulating tumor progression, metastasis, and response to therapies. Accurately modeling...
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Exosomes from senescent epithelial cells activate pulmonary fibroblasts via the miR-217-5p/Sirt1 axis in paraquat-induced pulmonary fibrosis
BackgroundParaquat (PQ) is a widely used and highly toxic herbicide that poses a significant risk to human health. The main consequence of PQ...
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Heterogeneous response to TGF-β1/3 isoforms in fibroblasts of different origins: implications for wound healing and tumorigenesis
Identification of therapeutic targets for treating fibrotic diseases and cancer remains challenging. Our study aimed to investigate the effects of...
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Role and mechanism of CD90+ fibroblasts in inflammatory diseases and malignant tumors
Fibroblasts are highly heterogeneous mesenchymal stromal cells, and different fibroblast subpopulations play different roles. A subpopulation of...
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IL-33/ST2 axis of human amnion fibroblasts participates in inflammatory reactions at parturition
BackgroundInflammation of the fetal membranes is an indispensable event of labor onset at both term and preterm birth. Interleukin-33 (IL-33) is...
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ETS1 governs pathological tissue-remodeling programs in disease-associated fibroblasts
Fibroblasts, the most abundant structural cells, exert homeostatic functions but also drive disease pathogenesis. Single-cell technologies have...
