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Accelerated Extracellular Nucleotide Metabolism in Brain Microvascular Endothelial Cells in Experimental Hypercholesterolemia
Hypercholesterolemia affects the neurovascular unit, including the cerebral blood vessel endothelium. Operation of this system, especially in the...
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Microglial Uptake of Extracellular Tau by Actin-Mediated Phagocytosis
Microglia are scavengers of the brain environment that clear dead cells, debris, and microbes. In Alzheimer’s disease, microglia get activated to...
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Plant-Derived Extracellular Nanovesicles for Disease Therapy
Natural plants and traditional Chinese medicines (TCMs) have been widely used throughout human history and are available in many pharmaceutical...
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Biological Functions of Extracellular Vesicles in Various Systems
Extracellular vesicles (EVs) are secreted by almost all cells and are widely found in biological fluids. EVs contain a variety of bioactive...
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Extracellular Vesicle Biomarkers for Renal Diseases
Extracellular vesicles (EVs) are emerging as a new mechanism of intercellular communication in renal disease. EVs originating from the renal system...
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Proteomic differences between extracellular vesicles and extracellular vesicle-depleted excretory/secretory products of barber’s pole worm
BackgroundComponents of excretory/secretory products (ESPs) of helminths have been proposed as vaccine targets and shown to play a role in modulating...
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Extracellular Vesicles and Cardiac Aging
Global population aging is a major challenge to health and socioeconomic policies. The prevalence of diseases progressively increases with aging,...
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Methods for Analysis of Extracellular Vesicle Functions
Extracellular vesicles (EVs) are nanoscale vesicles that are secreted by virtually all cells and are involved in numerous biological processes....
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Extracellular Purine Metabolism—Potential Target in Multiple Sclerosis
The purinergic signaling system comprises a complex network of extracellular purines and purine-metabolizing ectoenzymes, nucleotide and nucleoside...
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Extracellular MicroRNAs as Putative Biomarkers of Air Pollution Exposure
Air pollution is a global environmental and public health issue. Exposure to air pollution is associated with elevated risk of morbidity and...
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Gene Therapy of Extracellular Vesicles in Cardiovascular and Metabolic Diseases
The ultimate and most complex form of treating human diseases is embodied by gene therapy. For an effective gene therapeutic product we need to hack...
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Technologies Used for Analysis of Extracellular Vesicle-Omics
Extracellular vesicles (EVs) are naturally occurring and secreted membrane vesicles that carry proteins, lipids, and RNAs (mRNAs, microRNAs [miRNAs],...
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Brain alarm by self-extracellular nucleic acids: from neuroinflammation to neurodegeneration
Neurological disorders such as stroke, multiple sclerosis, as well as the neurodegenerative diseases Parkinson's or Alzheimer's disease are...
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The circadian regulation of extracellular ATP
Extracellular ATP is a potent signaling molecule released from various cells throughout the body and is intimately involved in the pathophysiological...
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LIPCAR levels in plasma-derived extracellular vesicles is associated with left ventricle remodeling post-myocardial infarction
BackgroundLong Intergenic noncoding RNA predicting CARdiac remodeling (LIPCAR) is a long noncoding RNA identified in plasma of patients after...
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Mechanical overload-induced release of extracellular mitochondrial particles from tendon cells leads to inflammation in tendinopathy
Tendinopathy is one of the most common musculoskeletal diseases, and mechanical overload is considered its primary cause. However, the underlying...
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Biosensing Technologies for Detection of Extracellular Vesicles
Extracellular vesicles (EVs) are novel biomarkers evaluated during liquid biopsy and are involved in many physiological functions in cells as well as...
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Extracellular vesicular lncRNA FAL1 promotes hepatocellular carcinoma cell proliferation and invasion by inducing macrophage M2 polarization
Current evidence finds that circulating exosomal lncRNA focally amplified lncRNA on chromosome 1 (FAL1) promotes the progression of hepatocellular...
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Extracellular MicroRNAs as Putative Biomarkers of Air Pollution Exposure
Air pollution is a global environmental and public health issue. Exposure to air pollution is associated with elevated risk of morbidity and...