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Enlightening Cardiac Arrhythmia with Optogenetics
Cardiac optogenetics offers unprecedented opportunities to study the role of different cell populations in complex biological tissues, such as the...
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Kv11.1 (hERG1) Channels and Cardiac Arrhythmia
The rapid delayed rectifier K+ current (IKr) is one of several outward currents that mediate repolarization of cardiac action potentials in humans...
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An end-end arrhythmia diagnosis model based on deep learning neural network with multi-scale feature extraction
This study presents an innovative end-to-end deep learning arrhythmia diagnosis model that aims to address the problems in arrhythmia diagnosis. The...
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DG-Map**: a novel software package for the analysis of any type of reentry and focal activation of simulated, experimental or clinical data of cardiac arrhythmia
In this work, we present the release of a novel easy to use software package called DGM or Directed-Graph-Map**. DGM can automatically analyze any...
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Role of NCX1 and NHE1 in Ventricular Arrhythmia
Lethal ventricular arrhythmias are one of the primary causes of high mortality among patients with a variety of cardiac diseases, like acute...
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Impact of calmodulin missense variants associated with congenital arrhythmia on the thermal stability and the degree of unfolding
Thermal denaturation profiles of proteins that bind several ligands may deviate from the single transition, making their thermodynamic description...
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Cardiac-specific deletion of BRG1 ameliorates ventricular arrhythmia in mice with myocardial infarction
Malignant ventricular arrhythmia (VA) after myocardial infarction (MI) is mainly caused by myocardial electrophysiological remodeling. Brahma-related...
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Forced activation of dystrophin transcription by CRISPR/dCas9 reduced arrhythmia susceptibility via restoring membrane Nav1.5 distribution
Dystrophin deficiency due to genetic mutations causes cardiac abnormalities in Duchenne’s muscular dystrophy. Dystrophin is also shown to be...
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Human macrophages directly modulate iPSC-derived cardiomyocytes at healthy state and congenital arrhythmia model in vitro
The electrophysiological regulation of cardiomyocytes (CMs) by the cardiac macrophages (MΦs) has been recently described as an unconventional role of...
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Cellular mechanisms and molecular pathways linking bitter taste receptor signalling to cardiac inflammation, oxidative stress, arrhythmia and contractile dysfunction in heart diseases
Heart diseases and related complications constitute a leading cause of death and socioeconomic threat worldwide. Despite intense efforts and research...
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Arrhythmia detection and classification using ECG and PPG techniques: a review
Electrocardiogram (ECG) and photoplethysmograph (PPG) are non-invasive techniques that provide electrical and hemodynamic information of the heart,...
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TRPC Channels in Cardiac Arrhythmia: Their Role during Purinergic Activation Induced by Ischemia
Cardiac electrical activity is mainly determined by a set of voltage-dependent channels that control depolarizing currents carried by Na+ and Ca2+...
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High-throughput functional map** of variants in an arrhythmia gene, KCNE1, reveals novel biology
BackgroundKCNE1 encodes a 129-residue cardiac potassium channel ( I Ks ) subunit. KCNE1 variants are associated with long QT syndrome and atrial...
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The role of calcium homeostasis remodeling in inherited cardiac arrhythmia syndromes
Sudden cardiac death due to malignant ventricular arrhythmias remains the major cause of mortality in the postindustrial world. Defective...
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Inherited Ventricular Arrhythmia in Zebrafish: Genetic Models and Phenoty** Tools
In the last years, the field of inheritable ventricular arrhythmia disease modelling has changed significantly with a push towards the use of novel...
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Automated detection of arrhythmia from electrocardiogram signal based on new convolutional encoded features with bidirectional long short-term memory network classifier
Early detection of cardiac arrhythmia is needed to reduce mortality. Automatically detecting the cardiac arrhythmias is a very challenging task. In...
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Knockout of interleukin-17A diminishes ventricular arrhythmia susceptibility in diabetic mice via inhibiting NF-κB-mediated electrical remodeling
Interleukin-17A (IL-17), a potent proinflammatory cytokine, has been shown to participate in cardiac electrical disorders. Diabetes mellitus is an...
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Deciphering the roles of triiodothyronine (T3) and thyroid-stimulating hormone (TSH) on cardiac electrical remodeling in clinical and experimental hypothyroidism
Hypothyroidism is the most frequent endocrine pathology. Although clinical or overt hypothyroidism has been traditionally associated to low T3 / T4...
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Targeting NLRP3 signaling reduces myocarditis-induced arrhythmogenesis and cardiac remodeling
BackgroundMyocarditis substantially increases the risk of ventricular arrhythmia. Approximately 30% of all ventricular arrhythmia cases in patients...
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The Short QT Syndrome
The short QT syndrome (SQTS) is characterised by abbreviated QT intervals on the electrocardiogram and by an increased risk of atrial and ventricular...