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Identification of Non-excitatory Amino Acids and Transporters Mediating the Irreversible Synaptic Silencing After Hypoxia
The contribution of excitatory amino acids (AA) to ischemic brain injury has been widely described. In addition, we reported that a mixture of...
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Effect of Noopept on the Content of Neurotransmitter Amino Acids in the Hippocampus in Alcoholized Rats Using In Vivo Microdialysis
Abstract — The aim of the present work was to study the dynamics of neurotransmitter amino acids after acute Noopept (a dipeptide analogue of piracetam...
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Systemic perturbations in amino acids/amino acid derivatives and tryptophan pathway metabolites associated with murine influenza A virus infection
BackgroundInfluenza A virus (IAV) is the only influenza virus causing flu pandemics (i.e., global epidemics of flu disease). Influenza (the flu) is a...
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The Effect of Pyridine Oxime Derivative (GIZh-298) and Sodium Valproate on the Neurotransmitter Amino Acids Content in the Brain Structures of Mice in the Maximal Electroshock Seizure Test
Abstract —Here we studied the effects of anti-epileptic substance GIZh-298 and the drug of comparison sodium valproate (NaV) on the contents of...
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The role of excitatory amino acid transporter 2 (EAAT2) in epilepsy and other neurological disorders
Glutamate is the major excitatory neurotransmitter in the central nervous system (CNS). Excitatory amino acid transporters (EAATs) have important...
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Influence of Amino Acids on Autism and Attention-Deficit Hyperactive Disorder
Recent reports illustrated the increasing universal occurrence of autism and attention-deficit hyperactivity disorder (ADHD). Much of the...
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Plasma branched-chain and aromatic amino acids correlate with the gut microbiota and severity of Parkinson’s disease
Disturbances of circulating amino acids have been demonstrated in patients with Parkinson’s disease (PD). However, there have been no consistent...
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Transformation of the Amino Acid Pool in the Rat Brain under Conditions of Experimental Immunodeficiency
Abstract —The immune system, as one of the integrating general regulatory systems of the body, is in close relationship with the nervous and endocrine...
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Molecular Basis of Coupled Transport and Anion Conduction in Excitatory Amino Acid Transporters
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system. After its release from presynaptic nerve terminals,...
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Heptapeptide Analogue of Tuftsin Prevents the Increase in the Content of Inhibitory Amino Acids in the Brain When Modeling Alcohol Withdrawal in Rats
Abstract —In mammals, chronic alcohol exposure disrupts the balance between excitatory and inhibitory neurotransmitter amino acids, including a...
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Interorgan Metabolism of Amino Acids in Human Health and Disease
Amino acids are integral for human health, influencing an array of physiological processes from gene expression to vasodilation to the immune...
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Evaluation of Branched-Chain Amino Acids in Children with Autism Spectrum Disorder and Epilepsy
Autism spectrum disorder (ASD) and epilepsy run hand-to-hand in their pathophysiology. Epilepsy is not an uncommon finding in patients with ASD. The...
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Amino Acid Transporters Proteins Involved in the Glutamate-Glutamine Cycle and Their Alterations in Murine Models of Alzheimer’s Disease
The brain’s ability to integrate external stimuli and generate responses is highly complex. While these mechanisms are not completely understood,...
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Nutrition and Functions of Amino Acids in Fish
Aquaculture is increasingly important for providing humans with high-quality animal protein to improve growth, development and health. Farm-raised...
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The Effect of Noopept on the Content of Monoamines and Their Metabolites and Neurotransmitter Amino Acids in the Brain Structures of BALB/c and C57BL/6 Mice: A Comparative Study
Abstract —The aim of this study was to compare neurochemical changes induced by the dipeptide analogue of piracetam, the ethyl ester of N -phenylacetyl-...
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Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis
Idiopathic autism spectrum disorder (ASD) is highly heterogeneous, and it remains unclear how convergent biological processes in affected individuals...
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Time and Brain Region-Dependent Excitatory Neurochemical Alterations in Bilateral Common Carotid Artery Occlusion Global Ischemia Model
Strict metabolic regulation in discrete brain regions leads to neurochemical changes in cerebral ischemia. Accumulation of extracellular glutamate is...
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Predictive Ability of Serum Amino Acid Levels to Differentiate Fibromyalgia Patients from Healthy Subjects
BackgroundFibromyalgia is a complex illness to diagnose and treat.
ObjectivesTo evaluate a broad range of circulating free amino acid (AA) levels in...
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Amino Acids and Their Metabolites for Improving Human Exercising Performance
Achieving adequate nutrition for exercising humans is especially important for improving both muscle mass and metabolic health. One of the most...
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Exogenous Adenosine Antagonizes Excitatory Amino Acid Toxicity in Primary Astrocytes
Excitatory toxicity is still a hot topic in the study of ischemic stroke, and related research has focused mainly on neurons. Adenosine is an...
