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Macrolides and Diseases Associated with Loss of Epithelial Barrier Integrity
In addition to the antiinflammatory/immunoregulatory actions of macrolide antibiotics, more recent investigations indicate the potential...
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Gut microbiota-derived 3-phenylpropionic acid promotes intestinal epithelial barrier function via AhR signaling
BackgroundThe intestinal epithelial barrier confers protection against the intestinal invasion by pathogens and exposure to food antigens and toxins....
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SARS-CoV-2 infects epithelial cells of the blood-cerebrospinal fluid barrier rather than endothelial cells or pericytes of the blood-brain barrier
BackgroundAs a consequence of SARS-CoV-2 infection various neurocognitive and neuropsychiatric symptoms can appear, which may persist for several...
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Blockade of PI3K/AKT signaling pathway by Astragaloside IV attenuates ulcerative colitis via improving the intestinal epithelial barrier
BackgroundThe specific pathogenesis of UC is still unclear, but it has been clear that defects in intestinal barrier function play an important role...
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Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis
Immune checkpoint inhibitor (ICI) therapy has revolutionized oncology, but treatments are limited by immune-related adverse events, including...
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Lactic acid from vaginal microbiota enhances cervicovaginal epithelial barrier integrity by promoting tight junction protein expression
BackgroundWomen with a cervicovaginal microbiota dominated by Lactobacillus spp. are at reduced risk of acquiring sexually transmitted infections...
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Tight Junctions, the Epithelial Barrier, and Toll-like Receptor-4 During Lung Injury
Lung epithelium is constantly exposed to the environment and is critically important for the orchestration of initial responses to infectious...
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Enteric glial adenosine 2B receptor signaling mediates persistent epithelial barrier dysfunction following acute DSS colitis
Intestinal epithelial barrier function is compromised in inflammatory bowel disease and barrier dysfunction contributes to disease progression....
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The Immune Barrier: Influence of Food Components on the Intestinal Barrier
The skin and mucous membranes of the body constitute the first defense element of the immune system. Single- to multilayered epithelial end tissues...
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Enteric glial cells aggravate the intestinal epithelial barrier damage by secreting S100β under high-altitude conditions
Damage to the intestinal epithelial barrier (IEB) has been reported under high-altitude (HA) conditions and may be responsible for HA-associated...
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Epithelial NELF guards intestinal barrier function to ameliorate colitis by maintaining junctional integrity
Well-orchestrated transcriptional programs in intestinal epithelial cells (IECs) are essential for maintenance of optimal mucosal barrier functions,...
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Blocked conversion of Lactobacillus johnsonii derived acetate to butyrate mediates copper-induced epithelial barrier damage in a pig model
BackgroundHigh-copper diets have been widely used to promote growth performance of pigs, but excess copper supplementation can also produce negative...
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Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity
Goblet cells secrete mucin to create a protective mucus layer against invasive bacterial infection and are therefore essential for maintaining...
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Determining the toxicological effects of indoor air pollution on both a healthy and an inflammatory-comprised model of the alveolar epithelial barrier in vitro
Exposure to indoor air pollutants (IAP) has increased recently, with people spending more time indoors ( i.e. homes, offices, schools and...
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Investigation of the Relation between Epithelial Barrier Function and Autism Symptom Severity in Children with Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder characterized by limitations in mutual communication and social interaction as...
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Changes of physico-chemical properties of nano-biomaterials by digestion fluids affect the physiological properties of epithelial intestinal cells and barrier models
BackgroundThe widespread use of nano-biomaterials (NBMs) has increased the chance of human exposure. Although ingestion is one of the major routes of...
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Baicalein ameliorates ulcerative colitis by improving intestinal epithelial barrier via AhR/IL-22 pathway in ILC3s
Ulcerative colitis (UC) is a chronic inflammatory disease of the gastrointestinal tract, which is closely related to gut barrier dysfunction....
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Gastric Epithelial Barrier Disruption, Inflammation and Oncogenic Signal Transduction by Helicobacter pylori
Helicobacter pylori exemplifies one of the most favourable bacterial pathogens worldwide. The bacterium colonizes the gastric mucosa in about half of...
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Epithelial-Neuronal Communication in Visceral Pain
Visceral hypersensitivity and pain are common symptoms of irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Pain results, at least...
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Sympathetic-Mediated Intestinal Cell Death Contributes to Gut Barrier Impairment After Stroke
Tissue injury induced by stroke is traditionally thought to be localised to the brain. However, there is an accumulating body of evidence to...
