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Epigenetic Chemicals
Epigenetic chemicals are chemical substances that exert their toxicity on individual inheritance through the epigenetic mechanism. In this chapter,...
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Developments in Epigenetic Cancer Therapeutics
Epigenetic changes can regulate the activity of the gene without altering the DNA sequence. Acetylation, methylation, and succinylation are the...
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Targeted Modification of Epigenetic Marks Using CRISPR/dCas9-SunTag-Based Modular Epigenetic Toolkit
The epigenome, consisting of chemical modifications to DNA and histone proteins, can alter gene expression. Clustered regularly interspaced short...
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Epigenetic modulation of ferroptosis in cancer: Identifying epigenetic targets for novel anticancer therapy
Ferroptosis is a newly recognized form of oxidative-regulated cell death resulting from iron-mediated lipid peroxidation accumulation....
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Developments in Epigenetic Cancer Therapeutics
Epigenetic changes can regulate the activity of the gene without altering the DNA sequence. Acetylation, methylation, and succinylation are the...
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Epigenetic Alterations as an Adaptive Response to Chemotherapy
The growing field of cancer research has revealed the complex interaction between epigenetic modifications and the development of drug resistance in...
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Epigenetic aging in older people living with HIV in Eswatini: a pilot study of HIV and lifestyle factors and epigenetic aging
BackgroundPeople living with HIV (PLHIV) on effective antiretroviral therapy are living near-normal lives. Although they are less susceptible to...
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The Epigenetic Landscape of Meningiomas
Epigenetic changes have been found to be increasingly important in tumor development and progression. These alterations can be present in tumors such...
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Epigenetic Control and Cerebellar Neurodevelopmental Disorders
Epigenetic mechanisms regulate cellular identity and organ morphology via instructing the gene expression program of specific cell types. Such...
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Epigenetic Therapy for Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with no effective treatments. Increasing evidence suggests that the epigenetic...
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Targeting the Epigenetic Landscape for Cancer Therapy
The role of epigenetics, focusing on changes in gene functions unrelated to DNA sequence, is becoming increasingly evident in cancer initiation,...
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How calorie restriction slows aging: an epigenetic perspective
Genomic instability and epigenetic alterations are some of the prominent factors affecting aging. Age-related heterochromatin loss and decreased...
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Epigenetic Modification in Aluminum-Induced Neurotoxicity
The toxicity of aluminum has been confirmed from many aspects, such as plant, animal, model organism, in vitro study, and epidemiological studies....
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Epigenetic Influences and Brain Development
Recent years have seen raid growth in the quantity of scientific data on the involvement of epigenetic processes in regulating brain development...
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Comparative epigenetic and genetic spatial structure in Mediterranean mountain plants: a multispecies study
Changes in epigenetic states can allow individuals to cope with environmental changes. If such changes are heritable, this may lead to epigenetic...
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Epigenetic variation impacts individual differences in the transcriptional response to influenza infection
Humans display remarkable interindividual variation in their immune response to identical challenges. Yet, our understanding of the genetic and...
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Epigenetic effects of herbal medicine
Epigenetic memory is essential for life that governs the predefined functional features of cells. Recent evidence has indicated that the epigenetic...
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Epigenetic regulation of breast cancer metastasis
Breast cancer is the most frequently diagnosed malignancy and the second leading cause of cancer-related mortality among women worldwide. Recurrent...
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Epigenetic control of pancreatic cancer metastasis
Surgical resection, when combined with chemotherapy, has been shown to significantly improve the survival rate of patients with pancreatic ductal...
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Epigenetic reprogramming of mtDNA and its etiology in mitochondrial diseases
Mitochondrial functionality and its regulation are tightly controlled through a balanced crosstalk between the nuclear and mitochondrial DNA...
