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Comparison of different dose accumulation strategies to estimate organ doses after stereotactic magnetic resonance-guided adaptive radiotherapy
IntroductionRe-irradiation is frequently performed in the era of precision oncology, but previous doses to organs-at-risk (OAR) must be assessed to...
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Cone beam CT-based dose accumulation and analysis of delivered dose to the dominant intraprostatic lesion in primary radiotherapy of prostate cancer
BackgroundEvaluation of delivered dose to the dominant intraprostatic lesion (DIL) for moderately hypofractionated radiotherapy of prostate cancer by...
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Biologically consistent dose accumulation using daily patient imaging
BackgroundThis work addresses a basic inconsistency in the way dose is accumulated in radiotherapy when predicting the biological effect based on the...
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Histopathological biomarkers for predicting the tumour accumulation of nanomedicines
The clinical prospects of cancer nanomedicines depend on effective patient stratification. Here we report the identification of predictive biomarkers...
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Intranasal Exposure to Low-Dose Rotenone Induced Alpha-Synuclein Accumulation and Parkinson’s Like Symptoms Without Loss of Dopaminergic Neurons
Epidemiologically Parkinson’s disease (PD) is associated with chronic ingestion or inhalation of environmental toxins leading to the development of...
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Reduced lysosomal activity and increased amyloid beta accumulation in silica-coated magnetic nanoparticles-treated microglia
Nanoparticles have been used in neurological research in recent years because of their blood–brain barrier penetration activity. However, their...
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Maximum Tolerated Dose (MTD) Studies in Drug Toxicology Assessments
In order to transition a new chemical entity (NCE) from the discovery arena into nonclinical development and potentially the clinic, a comprehensive...
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Use of a long-acting substitute in detoxification from benzodiazepines: safety (accumulation) problems and proposed mitigation procedure
ObjectiveIn the majority of approaches, detoxification of patients with benzodiazepine (BZD) addiction is preceded by conversion to long-acting BZDs....
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Dose Range Finding (DRF) Studies in Drug Toxicology Assessments
Early repeated dose-range finding (DRF) toxicology studies, usually conducted in rodent and non-rodent animal species, seek to provide the earliest...
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Piezo1 regulates meningeal lymphatic vessel drainage and alleviates excessive CSF accumulation
Piezo1 regulates multiple aspects of the vascular system by converting mechanical signals generated by fluid flow into biological processes. Here, we...
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Deferoxamine Ameliorates Cypermethrin-Induced Iron Accumulation and Associated Alterations
Iron is widely linked with the onset and development of Parkinson’s disease (PD). Accumulation of iron induces free radical generation and promotes...
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Low-dose metronomic cisplatin as an antiangiogenic and anti-inflammatory strategy for cancer
BackgroundConventional chemotherapy is based on the maximum tolerated dose (MTD) and requires treatment-free intervals to restore normal host cells....
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Repeated-dose toxicity and toxicokinetic study of isobutylparaben in rats subcutaneously treated for 13 weeks
Parabens have historically served as antimicrobial preservatives in a range of consumables such as food, beverages, medications, and personal care...
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Physiologically based pharmacokinetic model combined with reverse dose method to study the nephrotoxic tolerance dose of tacrolimus
Nephrotoxicity is the most common side effect that severely limits the clinical application of tacrolimus (TAC), an immunosuppressive agent used in...
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In vitro modulation of mTOR and mGlur5 influence α-synuclein accumulation
One of the main hallmarks of Parkinson’s disease (PD) is abnormal alpha-synuclein (α-syn) aggregation which forms the main component of intracellular...
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Recommendations on dose level selection for repeat dose toxicity studies
Prior to registering and marketing any new pharmaceutical, (agro)chemical or food ingredient product manufacturers must, by law, generate data to...
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Dose-dependent pleiotropic role of neutrophils during acetaminophen-induced liver injury in male and female mice
Acetaminophen (APAP) overdose is the leading cause of acute liver failure in western countries. APAP can cause extensive hepatocellular necrosis,...
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Non-linear dose response of DNA double strand breaks in response to chronic low dose radiation in individuals from high level natural radiation areas of Kerala coast
BackgroundThe human population living in high level natural radiation areas (HLNRAs) of Kerala coast provide unique opportunities to study the...
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Toxicokinetics of praseodymium and cerium administered as chloride salts in Sprague–Dawley rats: impacts of the dose and of co-exposure with additional rare earth elements
We conducted a rat exposure study to assess the impacts of dose and co-exposure with other rare earth elements (REEs) on the toxicokinetics of...
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Realgar-Induced Neurotoxicity: Crosstalk Between the Autophagic Flux and the p62-NRF2 Feedback Loop Mediates p62 Accumulation to Promote Apoptosis
Realgar is a traditional Chinese medicine that contains arsenic. It has been reported that the abuse of medicine-containing realgar has potential...
