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Densifying Co-Precipitated Amorphous Dispersions to Achieve Improved Bulk Powder Properties
PurposePrecipitation of amorphous solid dispersions has gained traction in the pharmaceutical industry given its application to pharmaceuticals with...
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Multivariate Analysis of Solubility Parameters for Drug-Polymer Miscibility Assessment in Preparing Raloxifene Hydrochloride Amorphous Solid Dispersions
The success of obtaining solid dispersions for solubility improvement invariably depends on the miscibility of the drug and polymeric carriers. This...
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Screening of Organic Small Molecule Excipients on Ternary Solid Dispersions Based on Miscibility and Hydrogen Bonding Analysis: Experiments and Molecular Simulation
The preparation of solid dispersions by mixing insoluble drugs with polymers is the main way to improve the aqueous solubility of drugs. The...
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Microfluidics-on-a-chip for designing celecoxib-based amorphous solid dispersions: when the process shapes the product
The fundamental idea underlying the use of amorphous solid dispersions (ASDs) is to make the most of the solubility advantage of the amorphous form...
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The Implications of Drug-Polymer Interactions on the Physical Stability of Amorphous Solid Dispersions
Amorphous solid dispersions (ASDs) are a formulation and development strategy that can be used to increase the apparent aqueous solubility of poorly...
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Continuous Manufacturing and Molecular Modeling of Pharmaceutical Amorphous Solid Dispersions
Amorphous solid dispersions enhance solubility and oral bioavailability of poorly water-soluble drugs. The escalating number of drugs with poor...
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Drug-Carrier Miscibility in Solid Dispersions of Glibenclamide and a Novel Approach to Enhance Its Solubility Using an Effervescent Agent
The present research aims to investigate the miscibility, physical stability, solubility, and dissolution rate of a poorly water-soluble...
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Comparative Study of Methods for the Pharmaceutical Preparation and Effectiveness of Darunavir Ethanolate Compositions with Mesoporous Carriers and Polymer Solid Dispersions
PurposeThe aim of this work was to study the effectiveness of various methods for improving the solubility and bioavailability of darunavir by...
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Solid Dispersions of Gefitinib Prepared by Spray Drying with Improved Mucoadhesive and Drug Dissolution Properties
Gefitinib is a tyrosine kinase inhibitor that is intended for oral administration yet suffers poor bioavailability along with undesirable side...
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Influence of Poloxamer on the Dissolution and Stability of Hot-Melt Extrusion–Based Amorphous Solid Dispersions Using Design of Experiments
The current study aimed to see the effects of poloxamer P407 on the dissolution performance of hydroxypropyl methylcellulose acetate succinate...
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Co-spray Drying Drugs with Aqueous Polymer Dispersions (APDs)—a Systematic Review
Aqueous colloidal dispersions of water-insoluble polymers (APDs) avoid hassles associated with the use of organic solvents and offer processing...
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Impact of Processing Methods on the Physico-chemical Properties of Posaconazole Amorphous Solid Dispersions
Background & PurposeDifferent methods have been exploited to generate amorphous solid dispersions (ASDs) of poorly water-soluble drugs. However, the...
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Enhancement of dissolution and oral bioavailability by adjusting microenvironment pH in crocetin ternary solid dispersions: Optimization, characterization, in vitro evaluation, and pharmacokinetics
The most promising active ingredient of Crocus sativus L., crocetin (CCT), has been demonstrated to possess many biological activities. However, only...
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Antioxidant-containing monoolein aqueous dispersions: a preliminary study
The present study describes a preliminary study on the use of monoolein aqueous dispersions (MADs) as delivery systems for antioxidant molecules,...
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Drug Release from Surfactant-Containing Amorphous Solid Dispersions: Mechanism and Role of Surfactant in Release Enhancement
PurposeTo understand how surfactants affect drug release from ternary amorphous solid dispersions (ASDs), and to investigate different mechanisms of...
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Enhancing Biopharmaceutical Attributes of Khellin by Amorphous Binary Solid Dispersions
Khellin, a furanochromone isolated from fruits and seeds of Ammi visnaga , is traditionally used in many eastern Mediterranean countries. The plant...
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Preparation and Evaluation of Siderol Amorphous Solid Dispersions: Selection of Suitable Matrix/Carrier
The present study investigates the preparation of amorphous solid dispersions (ASD) for the ent-kaurane diterpenoid siderol (SDR). Initially,...
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Preparation and Characterization of Ibrutinib Amorphous Solid Dispersions: a Discussion of Interaction Force
The aim of this study was to improve the solubility and dissolution of Ibrutinib (IBR), a biopharmaceutical classification system (BCS) class II...
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Design and Characterization of HY-038 Solid Dispersions via Spray Drying Technology: In Vitro and In Vivo Evaluations
The aim of this study was to prepare HY-038 solid dispersions (SDs) with single carrier at high drug loading and then forming a tablet to enhance...
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Role of Permeability on the Biopredictive Dissolution of Amorphous Solid Dispersions
An ideal dissolution test for amorphous solid dispersions (ASDs) should reflect physicochemical, physiological, and hydrodynamic conditions which...
