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Novel Antidepressant-Like Properties of the Iron Chelator Deferiprone in a Mouse Model of Depression
Depressed individuals who carry the short allele for the serotonin-transporter-linked promotor region of the gene are more vulnerable to stress and...
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Treatment Response of Deferiprone in Infratentorial Superficial Siderosis: a Systematic Review
Superficial siderosis describes haemosiderin deposition on the surface of the brain. When present on infratentorial structures, it can cause ataxia,...
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RETRACTED ARTICLE: Deferiprone Treatment in Aged Transgenic Tau Mice Improves Y-Maze Performance and Alters Tau Pathology
The accumulation of neurofibrillary tangles (NFTs), which is composed of abnormally hyperphosphorylated tau aggregates, is the classic neuropathology...
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Develo** an Analytical Method Based on Graphene Quantum Dots for Quantification of Deferiprone in Plasma
In the world of nanotechnology, graphene quantum dots (GQDs) have been considerably employed in numerous optical sensing and bioanalytical...
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Awareness and practical evaluation of correct use of iron chelators; a study to track the ambiguities of thalassemia patients on their medications in Iran
PurposeThis study aimed to evaluate the knowledge, attitude, and practice toward iron chelating agents (ICAs) in Iranian thalassemia major patients.
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Measuring Autophagic Cargo Flux with Keima-Based Probes
Autophagy and autophagy-associated genes are implicated in a growing list of cellular, physiological, and pathophysiological processes and...
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Reversal of genetic brain iron accumulation by N,N′-bis(2-mercaptoethyl)isophthalamide, a lipophilic metal chelator, in mice
N,N’- bis(2-mercaptoethyl)isophthalamide (NBMI) is a novel lipophilic metal chelator and antioxidant used in mercury poisoning. Recent studies have...
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LUHMES Dopaminergic Neurons Are Uniquely Susceptible to Ferroptosis
Ferroptosis is a necrotic cell death caused by lipid oxidation that may be responsible for neural degeneration in Parkinson’s disease. We assessed...
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Endolysosome iron restricts Tat-mediated HIV-1 LTR transactivation by increasing HIV-1 Tat oligomerization and β-catenin expression
HIV-1 transactivator of transcription (Tat) protein is required for HIV-1 replication, and it has been implicated in the pathogenesis of...
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Therapeutic Biomarkers in Friedreich’s Ataxia: a Systematic Review and Meta-analysis
Although a large array of biomarkers have been investigated in Friedreich’s ataxia (FRDA) trials, the optimal biomarker for assessing disease...
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Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated fatty liver disease in mice: potential involvement of PANoptosis
Ferroptosis is a new form of regulated cell death characterized by excessive iron accumulation and uncontrollable lipid peroxidation. The role of...
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Targeting ferroptosis in ischemia/reperfusion renal injury
Renal I/R injury is a severe medical condition contributing to acute kidney injury (AKI), leading to rapid kidney dysfunction and high mortality...
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Drugs in Selected Ataxias
In this chapter, drug treatment in the few treatable causes of degenerative ataxias will first be presented including vitamin deficiency, metabolic...
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Control of nutrient uptake by IRF4 orchestrates innate immune memory
Natural killer (NK) cells are innate cytotoxic lymphocytes with adaptive immune features, including antigen specificity, clonal expansion and memory....
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Metal Chelators as a Potential Therapeutic Agent for Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurological condition that causes behavioural abnormalities and a progressive decline in intellectual abilities....
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The Role of Iron Metabolism in Sepsis-associated Encephalopathy: a Potential Target
Sepsis-associated encephalopathy (SAE) is an acute cerebral dysfunction secondary to infection, and the severity can range from mild delirium to deep...
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Superficial Siderosis
Superficial siderosis (SS) is an uncommon and often underdiagnosed disorder caused by chronic or repeated hemorrhage in the subarachnoid space that...