Search

Search Results

1. Nanotechnology for Enhanced Cytoplasmic and Organelle Delivery of Bioactive Molecules to Immune Cells

   Immune cells stand as a critical component of the immune system to maintain the internal environment homeostasis. The dysfunction of immune cells can...

   **aoyu Li, Charos Omonova Tuychi qizi, ... Zhigui Su in Pharmaceutical Research

   Article 03 June 2022
   

2. Strategy for Cytoplasmic Delivery Using Inorganic Particles

   Endosome escape is a key process for intracellular uptake of intact biomolecules and therapeutics, such as nucleic acids. Lysosome escape is a more...

   Zhi ** Gordon Xu in Pharmaceutical Research

   Article Open access 02 February 2022
   

3. Editorial of Special Issue “Cytoplasmic Delivery of Bioactives”

   Zimei Wu in Pharmaceutical Research

   Article Open access 23 May 2022

4. Nanoparticle-Mediated Cytoplasmic Delivery of Messenger RNA Vaccines: Challenges and Future Perspectives

   The COVID-19 pandemic has left scientists and clinicians no choice but a race to find solutions to save lives while controlling the rapid spreading....

   Zimei Wu, Tonglei Li in Pharmaceutical Research

   Article 03 March 2021
   

5. Connexin-Containing Vesicles for Drug Delivery

   Connexin is a transmembrane protein present on the cell membrane of most cell types. Connexins assemble into a hexameric hemichannel known as...

   Mahmoud S. Hanafy, Zhengrong Cui in The AAPS Journal

   Article 24 January 2024
   

6. Synbiotics in Oral Drug Delivery

   Gut microbiota constitutes a variety of microorganism like bacteria, fungi, virus, rickettsiae, etc. Any imbalance in gut microbiota termed as...

   Girish Kumar, Tarun Virmani, ... Kamla Pathak in Synbiotics in Human Health: Biology to Drug Delivery

   Reference work entry 2024
   

7. Exosome: From biology to drug delivery

   In recent years, different advancements have been observed in nanosized drug delivery systems. Factors such as stability, safety and targeting...

   Himakshi Baruah, Anupam Sarma, ... Mridusmita Das in Drug Delivery and Translational Research

   Article 22 January 2024
   

8. Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia

   Background

   Progranulin (PGRN) haploinsufficiency due to progranulin gene ( GRN ) variants can cause frontotemporal dementia (FTD) with aberrant TAR...

   Wonjae Sung, Min-Young Noh, ... Seung Hyun Kim in Journal of Neuroinflammation

   Article Open access 13 February 2024
   

9. RNA Nanomedicine: Delivery Strategies and Applications

   Delivery of RNA using nanomaterials has emerged as a new modality to expand therapeutic applications in biomedical research. However, the delivery of...

   Junho Byun, Yina Wu, ... Yu-Kyoung Oh in The AAPS Journal

   Article 02 October 2023
   

10. Microfluidic Approaches for Gene Delivery and Therapy

    Gene editing techniques such as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR/Cas9) have been developed to target a gene into...

    Mayur Parekh, Zulfiqur Ali in Microfluidics in Pharmaceutical Sciences

    Chapter 2024
    

11. Polymeric Nanocarriers for the Delivery of Phytoconstituents

    In past decades, with the advent of nanotechnology, nanocarriers have been highlighted as promising drug delivery systems for therapeutic,...

    Kanika Verma, Akanksha Chaturvedi, ... Swapnil Sharma in Nanotechnology Based Delivery of Phytoconstituents and Cosmeceuticals

    Chapter 2024
    

12. The 60-year evolution of lipid nanoparticles for nucleic acid delivery

    Delivery of genetic information to the interior of target cells in vivo has been a major challenge facing gene therapies. This barrier is now being...

    P. R. Cullis, P. L. Felgner in Nature Reviews Drug Discovery

    Article 04 July 2024
    

13. Enhancing in situ cancer vaccines using delivery technologies

    In situ cancer vaccination refers to any approach that exploits tumour antigens available at a tumour site to induce tumour-specific adaptive immune...

    Ningqiang Gong, Mohamad-Gabriel Alameh, ... Michael J. Mitchell in Nature Reviews Drug Discovery

    Article 01 July 2024
    

14. Targeted gene delivery systems for T-cell engineering

    T lymphocytes are indispensable for the host systems of defense against pathogens, tumors, and environmental threats. The therapeutic potential of...

    Fengling Wang, Yong Huang, ... Wei Wang in Cellular Oncology

    Article 16 May 2024
    

15. Current application of dexamethasone-incorporated drug delivery systems for enhancing bone formation

    Background

    Dexamethasone (DEX) is a well-known anti-inflammatory and immunosuppressive drug applied broadly as an osteoinductive agent in bone...

    Thi Phuong Mai, Jun-Beom Park, ... Cheol Moon in Journal of Pharmaceutical Investigation

    Article 09 August 2023
    

16. Regulating lactate-related immunometabolism and EMT reversal for colorectal cancer liver metastases using shikonin targeted delivery

    Background

    There are few effective medications for treating colorectal cancer and liver metastases (CRLM). The interactions among glycolysis,...

    Li Long, Wei **ong, ... Yongzhuo Huang in Journal of Experimental & Clinical Cancer Research

    Article Open access 10 May 2023
    

17. Oral delivery of RNAi for cancer therapy

    Cancer is a major health concern worldwide and is still in a continuous surge of seeking for effective treatments. Since the discovery of RNAi and...

    Humayra Afrin, Renu Geetha Bai, ... Md Nurunnabi in Cancer and Metastasis Reviews

    Article 27 March 2023
    

18. Phosphoserine-86-HSPB1 (pS86-HSPB1) is cytoplasmic and highly induced in rat myometrium at labour

    Uterine myocytes during pregnancy proceed through a series of adaptations and collectively transform into a powerfully contractile tissue by term....

    E. I. Miskiewicz, A. Olaloku, ... D. J. MacPhee in Histochemistry and Cell Biology

    Article Open access 19 October 2022
    

19. N⁶-methyladenosine modification of circMARK2 enhances cytoplasmic export and stabilizes LIN28B, contributing to the progression of Wilms tumor

    Background

    The potential involvement of circular RNAs (circRNAs) and N ⁶ -methyladenosine (m ⁶ A) modification in the progression of Wilms tumor (WT) has...

    Guannan Shu, Zhang Zhao, ... Guochang Liu in Journal of Experimental & Clinical Cancer Research

    Article Open access 11 July 2024
    

20. Role of Block Copolymers in Targeted Drug Delivery

    In various fields of sciences, research on block copolymers has made significant contributions that have advanced our understanding regarding its...

    Rakesh E. Mutha, Piyush S. Bafna, ... Saurabh Maru in Block Co-polymeric Nanocarriers: Design, Concept, and Therapeutic Applications

    Chapter 2023