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An Integrative QbD Approach for the Development and Optimization of Controlled Release Compressed Coated Formulation of Water-Soluble Drugs
Controlled release dosage forms maintain regulated pharmacokinetic profile of drug substance within its therapeutic window by ensuring constant...
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Synthesis, Characterization, In Silico Analysis, and Pharmacological Evaluation of Metoprolol-Modified Saccharide Conjugates for Cardiovascular Targeting
Targeted drug delivery to selective cell has emerged as one of the most significant areas of biomedical engineering research today, so to optimize...
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Investigations on Compaction Behavior of Kollidon®SR-Based Multi-component Directly Compressed Tablets for Preparation of Controlled Release Diclofenac Sodium
The physics of tablets mixtures has gained much attention lately. The purpose of this work is to evaluate the compaction properties of Kollidon ® SR...
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Optimization of Unidirectional Mucoadhesive Buccal Patches Based on Chitosan and Pluronic® F-127 for Metoprolol Controlled Release: In Vitro and Ex Vivo Evaluations
PurposeThe aim of this work was to optimize unidirectional buccal patches loaded with metoprolol (MT-MBPs) to provide adequate mucoadhesive and water...
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Metabolomic profiling of metoprolol hypertension treatment reveals altered gut microbiota-derived urinary metabolites
IntroductionMetoprolol succinate is a long-acting beta-blocker prescribed for the management of hypertension (HTN) and other cardiovascular diseases....
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The role of beta-adrenoreceptors in postoperative ileus in rats
The aim of the research was to evaluate the influence of antagonists of specific beta-adrenergic receptor subtypes on bowel motility following...
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β1- and β1/β2-adrenergic receptor antagonists block 6-nitrodopamine-induced contractions of the rat isolated epididymal vas deferens
6-Nitrodopamine (6-ND) is an endogenous modulator of the contractility in the rat isolated epididymal vas deferens (RIEVD) and considered to be the...
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Biomaterials for Controlled Drug Delivery Applications
A drug delivery system (DDS) is by definition a platform that can transfer a therapeutic agent to the disease site in order to elicit and improve the...
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The role of the peripheral and central adrenergic system in the construction of the subjective emotional experience of panic
RationaleAlthough the study of emotions can look back to over 100 years of research, it is unclear which information the brain uses to construct the...
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Predicting Food Effects on Oral Extended-Release Drug Products: A Retrospective Evaluation
Theoretically, the risk of food effects for extended-release (ER) products compared to IR products may be less because: (1) postprandial...
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Selective Laser Sintering (SLS) in Pharmaceuticals
Rapidly develo** and evolving rapid prototy** technologies and the emergence of 3D printable materials integrated with drug moieties have...
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Oral Controlled Release Systems: Current Strategies and Challenges
Oral drug delivery route is the widely favored and adaptable for all as it is endowed with a maximum surface area when compared to the other routes...
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Increased Renal Dysfunction, Apoptosis, and Fibrogenesis Through Sympathetic Hyperactivity After Focal Cerebral Infarction
Sympathetic nervous system plays an important role in secondary injury of diseases. Accumulating evidence has observed association between ischemic...
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Pharmaceutical Formulation Development Based on the Polymers Obtained from Edible Plants: An Excellent Approach for the Betterment in Health-Care Services
Pharmacy is a professional health science that deals with the techniques and chemical sciences of preparing and dispensing drugs to ensure the safe...
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Preferential Oxycodone Loss of Physically Manipulated Abuse Deterrent Oxycodone HCl Extended Release Tablets Prepared for Nasal Insufflation Studies
A method to reproducibly mill abuse deterrent oxycodone hydrochloride (HCl) extended release (ER) tablets was developed for a nasal insufflation...
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Overdose and Alcohol Sensitive Immediate Release System (OASIS) for Deterring Accidental Overdose or Abuse of Drugs
Death from an accidental or intentional overdose of slee** tablets has increased exponentially in the USA. Furthermore, the simultaneous...
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Physiologically-Based Pharmacokinetic Models of CYP2D6 Substrate and Inhibitors Nebivolol, Cinacalcet and Mirabegron to Simulate Drug–Drug Interactions
Background and ObjectivesIndex substrates and inhibitors to investigate the role of the polymorphic enzyme, cytochrome P450 (CYP) 2D6, in the...
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The Neuro-cardiac Axis in Arrhythmogenesis: Role and Impact of Autonomic Modulation
The autonomic nervous system consisting of two limbs, the sympathetic and parasympathetic nervous system, plays a key role in the modulation of...
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The Renin-Angiotensin System and Cancer
The renin-angiotensin system (RAS), classically known for its role in cardiovascular homeostasis, is increasingly recognized to be dysregulated in...
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Prediction of maternal pharmacokinetics using physiologically based pharmacokinetic models: assessing the impact of the longitudinal changes in the activity of CYP1A2, CYP2D6 and CYP3A4 enzymes during pregnancy
Concerns over gestational effects on the disposition of drugs has highlighted the need for a better understanding of drug distribution and...
