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Complement System
The term complement refers to the ability of some non-specific proteins in human serum to complement, that is, augment the effects of other immune...
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Alzheimer’s disease-associated complement gene variants influence plasma complement protein levels
BackgroundAlzheimer’s disease (AD) has been associated with immune dysregulation in biomarker and genome-wide association studies (GWAS). GWAS hits...
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A guide to complement biology, pathology and therapeutic opportunity
Complement has long been considered a key innate immune effector system that mediates host defence and tissue homeostasis. Yet, growing evidence has...
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Mass cytometric analysis of the immune cell landscape after traumatic brain injury elucidates the role of complement and complement receptors in neurologic outcomes
Following traumatic brain injury (TBI), a neuroinflammatory response can persist for years and contribute to the development of chronic neurological...
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Influence of complement protein C1q or complement receptor C5aR1 on gut microbiota composition in wildtype and Alzheimer’s mouse models
The contribution of the gut microbiome to neuroinflammation, cognition, and Alzheimer’s disease progression has been highlighted over the past few...
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Complement propagates visual system pathology following traumatic brain injury
BackgroundTraumatic brain injury (TBI) is associated with the development of visual system disorders. Visual deficits can present with delay and...
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A single-cell lung atlas of complement genes identifies the mesothelium and epithelium as prominent sources of extrahepatic complement proteins
To understand functional duality of the complement system in host defense and lung injury, a more comprehensive view of its localized production in...
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Complement networks in gene-edited pig xenotransplantation: enhancing transplant success and addressing organ shortage
The shortage of organs for transplantation emphasizes the urgent need for alternative solutions. Xenotransplantation has emerged as a promising...
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Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington’s disease
Huntington’s disease (HD) is a devastating monogenic neurodegenerative disease characterized by early, selective pathology in the basal ganglia...
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The Role of the Complement System in Chronic Inflammatory Demyelinating Polyneuropathy: Implications for Complement-Targeted Therapies
Chronic inflammatory demyelinating polyneuropathy (CIDP) is the most common, heterogeneous, immune-mediated neuropathy, characterized by predominant...
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Gliosis-dependent expression of complement factor H truncated variants attenuates retinal neurodegeneration following ischemic injury
Inherited, age-related, and acute retinal diseases are often exacerbated by an aberrant or excessive activity of the complement system. Consequently,...
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Detection of Intracellular Complement Activation by Nanoparticles in Human T Lymphocytes
The complement system is complex and includes two main components: the systemic or plasma complement and the so-called intracellular complement or...
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Associations of cerebrospinal fluid complement proteins with Alzheimer’s pathology, cognition, and brain structure in non-dementia elderly
BackgroundCerebrospinal fluid (CSF) complement activation is a key part of neuroinflammation that occurs in the early stages of Alzheimer’s disease...
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Testosterone deficiency promotes arterial stiffening independent of sex chromosome complement
BackgroundSex hormones and sex chromosomes play a vital role in cardiovascular disease. Testosterone plays a crucial role in men’s health. Lower...
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Increased infiltration of CD4+ T cell in the complement deficient lymphedema model
BackgroundLymphedema is an intractable disease that can be caused by injury to lymphatic vessels, such as by surgical treatments for cancer. It can...
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Complement and Cancer Immunity
The complement system is a crucial mediator of the innate immune mechanisms; its three major activation pathways contribute to cellular homeostasis,...
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Role of the complement system in kidney cell death induced by Loxosceles venom Sphingomyelinases D
Envenomation by Loxosceles spiders can result in local and systemic pathologies. Systemic loxoscelism, which can lead to death, is characterized by...
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Thinking inside the box: intracellular roles for complement system proteins come into focus
Over the last decade, perspectives on the complement system in the context of cancer have shifted, with complement proteins now implicated in many of...
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Complement Inhibition in Kidney Transplantation: Where Are We Now?
Kidney transplantation is a life-saving strategy for patients with end-stage renal disease. Although progress has been made in the field of...
