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Areca Thirteen Pill Improves Depression in Rat by Modulation of the Chemokine/Chemokine Receptor Axis
Depressive disorder is a severe and complex mental illness. There are a few anti-depressive medications that can reduce depressive symptoms, but with...
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The chemokine receptor CCR5: multi-faceted hook for HIV-1
Chemokines are cytokines whose primary role is cellular activation and stimulation of leukocyte migration. They perform their various functions by...
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Chemokine and Cytokine Networks in Tumor Microenvironment
A large family of tiny chemotactic cytokines direct the migration of immune cells and is known as chemokines. Chemotactic factors help the immune...
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Atypical chemokine receptors in the immune system
Leukocyte migration is a fundamental component of innate and adaptive immune responses as it governs the recruitment and localization of these motile...
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Inhibition of CC chemokine receptor 1 ameliorates osteoarthritis in mouse by activating PPAR-γ
BackgroundOsteoarthritis (OA) is a degenerative joint disease characterized by cartilage destruction and inflammation. CC chemokine receptor 1...
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Chemokines and Chemokine Receptors in Cancer: An Update
The chemokine family is composed of small chemotactic cytokines and receptors that mediate the infiltration of various immune cells. According to the...
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The synthetic opioid fentanyl increases HIV replication and chemokine co-receptor expression in vitro
The US is experiencing a major public health crisis that is fueled by the illicit use of synthetic opioids including fentanyl. While several drugs of...
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Cysteine-cysteine Chemokine Receptor Type 5 Plays a Critical Role in Exercise Performance by Regulating Mitochondrial Content in Skeletal Muscle
Cysteine-cysteine chemokine receptor type 5 (CCR5) is thought to play an important role in the trafficking of lymphoid cells but has recently also...
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Introduction to Cytokine and Chemokine Networks
Cytokines are small-molecular-weight, proteinaceous, immunomodulating molecules that are crucial for controlling the growth and activity of blood and...
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Activation of the CXCR4 Receptor by Chemokine CXCL12 Increases the Excitability of Neurons in the Rat Central Amygdala
Primarily regarded as immune proteins, chemokines are emerging as a family of molecules serving neuromodulatory functions in the develo** and adult...
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CC chemokine receptors are prognostic indicators of gastric cancer and are associated with immune infiltration
BackgroundCC chemokine receptors are responsible for regulating the tumor microenvironment (TME) and participating in carcinogenesis and tumor...
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C–C chemokine receptor 5 is essential for conventional NK cell trafficking and liver injury in a murine hepatitis virus-induced fulminant hepatic failure model
BackgroundPrevious studies have demonstrated that natural killer (NK) cells migrated into the liver from peripheral organs and exerted cytotoxic...
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NMR Methods for Characterization of Glycosaminoglycan–Chemokine Interactions
Humans express around 50 chemokines that play crucial roles in human pathophysiology from combating infection to immune surveillance by directing and...
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Chemokine receptor CCR9 suppresses the differentiation of CD4+CD8αα+ intraepithelial T cells in the gut
The chemokine receptor CCR9 equips T cells with the ability to respond to CCL25, a chemokine that is highly expressed in the thymus and the small...
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Chemokine receptor 7 contributes to T- and B-cell filtering in ageing bladder, cystitis and bladder cancer
BackgroundResearch has suggested significant correlations among ageing, immune microenvironment, inflammation and tumours. However, the relationships...
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New genetic and epigenetic insights into the chemokine system: the latest discoveries aiding progression toward precision medicine
Over the past thirty years, the importance of chemokines and their seven-transmembrane G protein-coupled receptors (GPCRs) has been increasingly...
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Chemokine and Cytokine Network in Angiogenesis
Angiogenesis is a hallmark of cancer and has been the target of new therapies since last few years; however, it is a complex process and involves...
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Methods to Assess Chemokine Binding and Anti-chemotactic Activity of Virus Proteins
Chemokines are key instigators of inflammatory and immune responses. Viruses can suppress these responses by secreting proteins that interfere with...
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Cytokine and chemokine map of peripheral specific immune cell subsets in Parkinson’s disease
Peripheral immune cells play a vital role in the development of Parkinson’s disease (PD). However, their cytokine and chemokine secretion functions...
