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Cardiac Ion Channels and Heart Rate and Rhythm
The excitability of the heart is a prerequisite for its function as a pump distributing blood throughout the body. Initiated in the sinoatrial node,...
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PREDICTION OF THE RISK OF SUDDEN CARDIAC DEATH BASED ON HEART RATE VARIABILITY ANALYSIS AND THE DIAGNOSIS OF DANGEROUS RHYTHM DISORDERS
A method for the differential diagnosis of dangerous cardiac arrhythmias at short time intervals is proposed. The possibility of detecting...
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Heart Rate and Rhythm Molecular Basis, Pharmacological Modulation and Clinical Implications
This completely updated and expanded 2nd Edition provides all the information needed in order to understand the complex molecular, cellular and...
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Circadian rhythm of intraocular pressure
Intraocular pressure (IOP) plays a crucial role in glaucoma development, involving the dynamics of aqueous humor (AH). AH flows in from the ciliary...
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Role of Circadian Rhythm in Hormonal Cancers
Circadian rhythm is a fundamental biological process that regulates various physiological functions in the body, including the secretion of hormones....
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Enlightening Cardiac Arrhythmia with Optogenetics
Cardiac optogenetics offers unprecedented opportunities to study the role of different cell populations in complex biological tissues, such as the...
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Molecular mechanisms of artificial light at night affecting circadian rhythm disturbance
Artificial light at night (ALAN) pollution has been regarded as a global environmental concern. More than 80% of the global population is exposed to...
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L-Type Ca2+ Channels and Cardiac Arrhythmias
L-type Ca2+ channels (LTCC) are voltage-gated Ca2+ channels with particular importance for cardiac function. They mediate Ca2+-induced Ca2+ release...
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Dose-Dependent Heart Rhythm Disturbance Occurring in Response to the Activation of Choline-Reactive Structures in Early Rat Ontogeny
The effect of dose-dependent activation of cholinoreactive structures on the severity of sinus bradycardia occurring in some intact newborn rats...
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Mechano-Electric Coupling in the Heart: Effects on Heart Rate and Rhythm
Cardiac electrical and mechanical activity are closely interrelated, not only via the chain of events commonly referred to as ‘excitation-contraction...
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Long-term continuous monitoring of arrhythmias in pigs with insertable cardiac monitors
Arrhythmia detection is essential when assessing the safety of novel drugs and therapies in preclinical studies. Many short-term arrhythmia...
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Benzonatate Overdose Presenting as Cardiac Arrest with Rapidly Narrowing QRS Interval
IntroductionBenzonatate is a local anesthetic-like sodium channel antagonist that is widely prescribed as an antitussive. While it may be reasonable...
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Age-related increases in cardiac excitability, refractoriness and impulse conduction favor arrhythmogenesis in male rats
The effects of excitability, refractoriness, and impulse conduction have been independently related to enhanced arrhythmias in the aged myocardium in...
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Cardiac Development at a Single-Cell Resolution
Mammalian cardiac developmentCardiacdevelopment is a complex, multistage process. Though traditional lineage tracing studies have characterized the...
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Transcutaneous vagus nerve stimulation ameliorates cardiac abnormalities in chronically stressed rats
Chronically stressed patients often have low vagal tone and increased levels of proinflammatory cytokines, which increase their risk for develo**...
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In silico optical modulation of spiral wave trajectories in cardiac tissue
Life-threatening cardiac arrhythmias such as ventricular tachycardia and fibrillation are common precursors to sudden cardiac death. They are...
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TRPC Channels in Cardiac Arrhythmia: Their Role during Purinergic Activation Induced by Ischemia
Cardiac electrical activity is mainly determined by a set of voltage-dependent channels that control depolarizing currents carried by Na+ and Ca2+...
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Cardiac Disease Modeling with Engineered Heart Tissue
The rhythmically beating heart is the foundation of life-sustaining blood flow. There are four chambers and many different types of cell in the...