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Are Multi-Component Drugs Better in Resolving the Inflammation Compared to the Single-Component Drugs?
As the cost of develo** novel single-component drugs is always increasing, multi-component drugs could be seen as a solution. Diseases often affect...
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Fine map** of candidate effector genes for heart rate
An elevated resting heart rate (RHR) is associated with increased cardiovascular mortality. Genome-wide association studies (GWAS) have...
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Candidate Translational Characterization
Promising clinical candidates undergo extensive translational characterization prior to advancement into activities required for first-in-human...
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Repurposing of Drugs in Aging
Aging is a complex biological process characterized by a gradual decline in physiological functions and an increased susceptibility to age-related...
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Therapeutic efficacy of candidate antischistosomal drugs in a murine model of schistosomiasis mansoni
Schistosomiasis is a neglected tropical disease associated with considerable morbidity . Praziquantel (PZQ) is effective against adult schistosomes,...
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Antimalarial Drugs and Drug Resistance
WHO estimated 241 million malaria cases in 2020 in 85 different malaria-endemic countries, more than in 2019. The reduction of cases due to...
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Discovery of SARS-CoV-2 Antiviral Drugs Through Large-Scale Virtual Screening of FDA-Approved Drugs
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent responsible for the viral pneumonia outbreak of coronavirus...
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Chronology of Anticancer Drugs and Their Development
Chemotherapeutic drugs, or anticancer, are the chemical components which are used to treat cancer. The term anticancer drugs evolved in the era of...
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A method for predicting drugs that can boost the efficacy of immune checkpoint blockade
Combination therapy is a promising therapeutic strategy to enhance the efficacy of immune checkpoint blockade (ICB); however, predicting drugs for...
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Development of complemented comprehensive networks for rapid screening of repurposable drugs applicable to new emerging disease outbreaks
BackgroundComputational drug repurposing is crucial for identifying candidate therapeutic medications to address the urgent need for develo**...
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Harnessing large language models (LLMs) for candidate gene prioritization and selection
BackgroundFeature selection is a critical step for translating advances afforded by systems-scale molecular profiling into actionable clinical...
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Analysis of 10,478 cancer genomes identifies candidate driver genes and opportunities for precision oncology
Tumor genomic profiling is increasingly seen as a prerequisite to guide the treatment of patients with cancer. To explore the value of whole-genome...
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The Competitive Counterflow Assay for Identifying Drugs Transported by Solute Carriers: Principle, Applications, Challenges/Limits, and Perspectives
The identification of substrates for solute carriers (SLCs) handling drugs is an important challenge, owing to the major implication of these plasma...
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Drugs from Nature: Targets, Assay Systems, and Leads
The overview is done to determine whether the era of natural products for drug discovery is over or not over. Though the drug discovery process is...
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Repurposing Drugs for Treatment of Age-Related Macular Degeneration
The need for new drugs to treat dry forms of age-related macular degeneration remains high. A promising approach is repurposing of FDA-approved...
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High-Throughput Screening Assay Identifies Berberine and Mubritinib as Neuroprotection Drugs for Spinal Cord Injury via Blood-Spinal Cord Barrier Protection
Because the breakdown of the blood–brain spinal cord barrier (BBSCB) worsens many central nervous system (CNS) diseases, prevention of BBSCB...
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Identifying the tumor location-associated candidate genes in development of new drugs for colorectal cancer using machine-learning-based approach
Numerous studies have been conducted to elucidate the relation of tumor proximity to cancer prognosis and treatment efficacy in colorectal cancer....
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Chronology of Anticancer Drugs and Their Development
Chemotherapeutic drugs, or anticancer, are the chemical components which are used to treat cancer. The term anticancer drugs evolved in the era of...
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Insights on Various Antiviral Drugs for Treating Patients with COVID-19
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was the cause of the first pandemic of the twenty-first century, which began in...
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The pipeline for drugs for control and elimination of neglected tropical diseases: 1. Anti-infective drugs for regulatory registration
The World Health Organization ‘Ending the neglect to attain the Sustainable Development Goals: A road map for neglected tropical diseases 2021–2030’...
