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Biomedicine

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Showing 1-4 of 4 results

  1. Genomic and transcriptomic profiling of combined small-cell lung cancer through microdissection: unveiling the transformational pathway of mixed subtype

    Background

    Combined small-cell lung carcinoma (cSCLC) represents a rare subtype of SCLC, the mechanisms governing the evolution of cancer genomes and...

    Wenjuan Ma, Ting Zhou, ... Li Zhang in Journal of Translational Medicine
    Article Open access 21 February 2024

  2. PARP inhibitor resistance: the underlying mechanisms and clinical implications

    Due to the DNA repair defect, BRCA1/2 deficient tumor cells are more sensitive to PARP inhibitors (PARPi) through the mechanism of synthetic...

    He Li, Zhao-Yi Liu, ... **g Wang in Molecular Cancer
    Article Open access 20 June 2020

  3. Determinants of CPT-11 and SN-38 activities in human lung cancer cells

    Irinotecan (CPT-11) is a semisynthetic camptothecin derivative with a broad spectrum of anti-tumour activity. Carboxylesterase (CE) catalyses the...

    J van Ark-Otte, MA Kedde, ... G Giaccone in British Journal of Cancer
    Article 01 June 1998

  4. Flow cytometric analysis of Hoechst 33342 uptake as an indicator of multi-drug resistance in human lung cancer

    Cytotoxic drug resistance develo** after chemotherapy is thought to be the main cause of treatment failure in several human tumours, including...

    SA Morgan, JV Watson, ... PJ Smith in British Journal of Cancer
    Article 01 September 1989
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