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Liensinine reduces acute lung injury brought on by lipopolysaccharide by inhibiting the activation of the NF-κB signaling pathway through modification of the Src/TRAF6/TAK1 axis
ALI is characterized by macrophage-driven inflammation, causing severe lung damage. Currently, there are limited therapeutic options available for...
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Inhibition of Maternal c-Src Ameliorates the Male Offspring Hypertension by Suppressing Inflammation and Neurotransmitters in the Paraventricular Nucleus
Long-term maternal salt intake induces the hypertension in offspring. Numerous studies have also indicated that high-salt diet causes the...
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Human T-cell lymphotropic virus type 1 (HTLV-1) grip on T-cells: investigating the viral tapestry of activation
IntroductionHuman T-cell Lymphotropic virus type 1 (HTLV-1) belongs to retroviridae which is connected to two major diseases, including...
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Aberrant activation of AXL may drive progression of squamous cell carcinoma in CLL patients: a mechanistic study with clinical implications
BackgroundOccurrence of squamous cell carcinoma (SCC) even in early-stage, untreated chronic lymphocytic leukemia (CLL) patients can be a significant...
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TRPA1 activation and Hsp90 inhibition synergistically downregulate macrophage activation and inflammatory responses in vitro
BackgroundTransient receptor potential ankyrin 1 (TRPA1) channels are known to be actively involved in various pathophysiological conditions,...
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Loss of SPRY2 contributes to cancer-associated fibroblasts activation and promotes breast cancer development
The communication between tumor cells and tumor microenvironment plays a critical role in cancer development. Cancer-associated fibroblasts (CAFs)...
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The tobacco-specific carcinogen NNK induces pulmonary tumorigenesis via nAChR/Src/STAT3-mediated activation of the renin-angiotensin system and IGF-1R signaling
The renin-angiotensin (RA) system has been implicated in lung tumorigenesis without detailed mechanistic elucidation. Here, we demonstrate that...
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The disruptor of telomeric silencing 1-like (DOT1L) promotes peritoneal fibrosis through the upregulation and activation of protein tyrosine kinases
The disruptor of telomeric silencing 1-like (DOT1L), a specific histone methyltransferase that catalyzed methylation of histone H3 on lysine 79, was...
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Protein–protein-interaction assay coupled with proteome profiler and immune activation flow cytometry assay validate immune activation in 3D oral cancer-immune co-culture model
Immune evasion is one of the hallmarks of cancer progression. Immunotherapy failed to produce appreciable treatment response in aggressive oral...
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A stepwise activation model for the insulin receptor
The binding of insulin to the insulin receptor (IR) triggers a cascade of receptor conformational changes and autophosphorylation, leading to the...
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PAK and PI3K pathway activation confers resistance to KRASG12C inhibitor sotorasib
BackgroundKRAS is a frequently mutated oncogene in human cancer. Clinical studies on the covalent inhibitors of the KRAS G12C mutant have reported...
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Exploring the putative role of PRDM1 and PRDM2 transcripts as mediators of T lymphocyte activation
BackgroundT cell activation and programming from their naïve/resting state, characterized by widespread modifications in chromatin accessibility...
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Association of TRAIL receptor with phosphatase SHP-1 enables repressing T cell receptor signaling and T cell activation through inactivating Lck
BackgroundT cell receptor (TCR) signaling and T cell activation are tightly regulated by gatekeepers to maintain immune tolerance and avoid...
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Immunopathology of and potential therapeutics for secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome: a translational perspective
Secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome (sHLH/MAS) is a life-threatening immune disorder triggered by rheumatic...
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Activation of leukotriene B4 receptor 1 is a prerequisite for complement receptor 3-mediated antifungal responses of neutrophils
Invasive fungal infections are life-threatening, and neutrophils are vital cells of the innate immune system that defend against them. The role of...
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Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease
Recent genetic studies on Alzheimer’s disease (AD) have brought microglia under the spotlight, as loci associated with AD risk are enriched in genes...
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Activated Src requires Cadherin-11, Rac, and gp130 for Stat3 activation and survival of mouse Balb/c3T3 fibroblasts
We previously demonstrated that engagement of cadherins, cell to cell adhesion molecules, triggers a dramatic increase in levels and activity of the...
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AKT Isoforms in Macrophage Activation, Polarization, and Survival
Macrophages display an array of activation phenotypes depending on the activation signal and the cellular microenvironment. The type and magnitude of...
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Activation and Functions of Plasmacytoid Dendritic Cells
The major functional identity of plasmacytoid dendritic cells (pDCs), despite their ontogenic affiliation to the dendritic cell (DC) lineage of...
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Optogenetic dissection of RET signaling reveals robust activation of ERK and enhanced filopodia-like protrusions of regenerating axons
RET (REarranged during Transfection) is a receptor tyrosine kinase that transduces various external stimuli into biological functions, such as...
