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Design, synthesis, and biological evaluation of 2, 4-dichlorophenoxyacetamide chalcone hybrids as potential c-Met kinase inhibitors
c-Met is involved in cellular processes that lead to the development and progression of cancer. A series of 2, 4-dichlorophenoxyacetamide-chalcones...
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Progress of antibody–drug conjugates (ADCs) targeting c-Met in cancer therapy; insights from clinical and preclinical studies
The cell-surface receptor tyrosine kinase c-mesenchymal-epithelial transition factor (c-Met) is overexpressed in a wide range of solid tumors, making...
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Suppression of TNBC metastasis by doxazosin, a novel dual inhibitor of c-MET/EGFR
BackgroundTriple-negative breast cancer (TNBC) is characterized by aggressive growth and a high propensity for recurrence and metastasis....
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HGF-mediated elevation of ETV1 facilitates hepatocellular carcinoma metastasis through upregulating PTK2 and c-MET
BackgroundMetastasis is a major determinant of death in patients with hepatocellular carcinoma (HCC). Dissecting key molecular mediators that promote...
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Safety, efficacy and pharmacokinetics of BPI-9016M in c-MET overexpression or MET exon 14 skip** mutation patients with locally advanced or metastatic non-small-cell lung cancer: a phase Ib study
BackgroundAs a potential target receptor tyrosine kinase, mesenchymal-epithelial transition factor ( MET ) exhibits high aberrant expression across...
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Molecular mechanism(s) of regulation(s) of c-MET/HGF signaling in head and neck cancer
Head and neck cancer is the sixth most common cancer across the globe. This is generally associated with tobacco and alcohol consumption. Cancer in...
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c-MET-positive circulating tumor cells and cell-free DNA as independent prognostic factors in hormone receptor-positive/HER2-negative metastatic breast cancer
BackgroundEndocrine therapy resistance in hormone receptor-positive/HER2-negative (HR+/HER2−) breast cancer (BC) is a significant clinical challenge...
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The anti-tumor effects of AZD4547 on ovarian cancer cells: differential responses based on c-Met and FGF19/FGFR4 expression
BackgroundThe FGF/FGFR signaling pathway plays a critical role in human cancers. We analyzed the anti-tumor effect of AZD4547, an inhibitor targeting...
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Effects of Ephedra Herb extract on the expression of EGFR-activating mutations and c-Met in non-small-cell lung cancer cell line, H1975, and its combined effects with osimertinib
We previously reported that the combined application of Ephedra Herb extract (EHE) and epidermal growth factor receptor (EGFR)-tyrosine kinase...
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CD4+c-Met+Itgα4+ T cell subset promotes murine neuroinflammation
Objectivec-Met, a tyrosine kinase receptor, is the unique receptor for hepatocyte growth factor (HGF). The HGF/c-Met axis is reported to modulate...
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c-Met up-regulates the expression of PD-L1 through MAPK/NF-κBp65 pathway
AbstractSorafenib acquired drug resistance during the treatment of hepatocellular carcinoma (HCC) reduces the efficacy of the drug. The immune escape...
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Significance of tumor heterogeneity of p-Smad2 and c-Met in HER2-positive gastric carcinoma with lymph node metastasis
BackgroundTumor heterogeneity has frequently been observed in gastric cancer (GC), but the correlation between patients’ clinico-pathologic features...
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LncRNA HOTTIP Knockdown Attenuates Acute Myocardial Infarction via Regulating miR-92a-2/c-Met Axis
Increasing investigations have focused on long non-coding RNAs (lncRNAs) in various human diseases, including acute myocardial infarction (AMI)....
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Recent Advances in FDA-Approved Kinase Inhibitors Targeting Lung Cancer
Lung cancer is a chronic deadly disease and is implicated with highest mortality rate among all cancers since years. Kinase are the...
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B3GALT4 remodels the tumor microenvironment through GD2-mediated lipid raft formation and the c-met/AKT/mTOR/IRF-1 axis in neuroblastoma
BackgroundBeta-1,3-galactosyltransferase-4 (B3GALT4) plays a critical regulatory role in tumor biology. However, the role of B3GALT4 in modulating...
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Mesothelioma-associated fibroblasts enhance proliferation and migration of pleural mesothelioma cells via c-Met/PI3K and WNT signaling but do not protect against cisplatin
BackgroundPleural mesothelioma (PM) is an aggressive malignancy with poor prognosis . Unlike many other cancers, PM is mostly characterized by...
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Molecular mechanism study of HGF/c-MET pathway activation and immune regulation for a tumor diagnosis model
BackgroundHepatocyte growth factor (HGF) binds to the c-mesenchymal-epithelial transition (C-MET) receptor and activates downstream signaling...
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Recent Advances in FDA-Approved Kinase Inhibitors Targeting Lung Cancer
Lung cancer is a chronic deadly disease and is implicated with highest mortality rate among all cancers since years. Kinase are the...
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HGF/c-Met Signalling in the Tumor Microenvironment
Recently, it has become clearer that tumor plasticity increases the chance that cancer cells could acquire new mechanisms to escape immune...
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Verticillin A inhibits colon cancer cell migration and invasion by targeting c-Met
Verticillin A is a diketopiperazine compound which was previously isolated from Amanita flavorubescens Alk (containing parasitic fungi Hypomyces...