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Identification of m6A methylation-related genes in cerebral ischaemia‒reperfusion of Breviscapus therapy based on bioinformatics methods
BackgroundCerebral ischaemia‒reperfusion (I/R) frequently causes late-onset neuronal damage. Breviscapine promotes autophagy in microvascular...
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Breviscapine
Breviscapine is extracted from Erigeron breviscapus, the main component of which is scutellarin. Breviscapine has a good pharmacological activity in...
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Phospholipid Complex Formulation Technology for Improved Drug Delivery in Oncological Settings: a Comprehensive Review
Addressing poor solubility and permeability issues associated with synthetic drugs and naturally occurring active compounds is crucial for improving...
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Effects of linalool on postoperative peritoneal adhesions in rats
The current study examines the effects of linalool in preventing postoperative abdominal adhesions. Twenty male Wistar rats were randomly divided...
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Injectable Formulations of Poorly Water-Soluble Drugs
Each year, an increasing number of new molecular entities in the drug development pipeline are characterized as having poor water solubility. While...
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Unwinding Helicase MCM Functionality for Diagnosis and Therapeutics of Replication Abnormalities Associated with Cancer: A Review
The minichromosome maintenance (MCM) protein is a component of an active helicase that is essential for the initiation of DNA replication....
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Effect of breviscapine on CYP3A metabolic activity in healthy volunteers
ObjectiveThe purpose of this study was to investigate the influence of breviscapine on the pharmacokinetics of concomitantly administered midazolam...
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Nanotechnology in Drug Delivery: How Compatible It Is for TCM Drug Delivery
Traditional Chinese medicine (TCM) is a treasure of the traditional culture of the Chinese nation, although many Chinese medicine ingredients have...
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Role of polyphenolic compounds and their nanoformulations: a comprehensive review on cross-talk between chronic kidney and cardiovascular diseases
Chronic kidney disease (CKD) affects a huge portion of the world’s population and frequently leads to cardiovascular diseases (CVDs). It might be...
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Aloe-emodin inhibits African swine fever virus replication by promoting apoptosis via regulating NF-κB signaling pathway
African swine fever (ASF) is an acute infectious haemorrhagic fever of pigs caused by African swine fever virus (ASFV). Aloe-emodin (Ae) is an active...
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Design, synthesis of amide derivatives of scutellarin and their antileukemia and neuroprotective activities
A unique series of amide-scutellarin derivatives were designed and synthesized in order to develop the function of scutellarin further. The...
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Antioxidant Therapy for High Altitude Sickness and Nano-Medicine
High altitude sickness is associated with increased levels of reactive oxygen species (ROS) that leads to oxidative stress in cells. At elevated...
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Natural products: potential treatments for cisplatin-induced nephrotoxicity
Cisplatin is a clinically advanced and highly effective anticancer drug used in the treatment of a wide variety of malignancies, such as head and...
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Phospholipid Complexation for Bioavailability Improvement of Albendazole: Preparation, Characterization and In Vivo Evaluation
The current study aimed to improve the poor solubility of albendazole (ABZ) by means of phospholipid complexation, hence to improve its oral...
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Microparticulate Drug Delivery Systems for Chinese Medicines
Microparticulate drug delivery system of Chinese medicine refers to particles within 1–1000 μm using microencapsulation technology to load the active...
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Mitochondria-Endoplasmic Reticulum Contact Sites (MERCS): A New Axis in Neuronal Degeneration and Regeneration
Mitochondria-Endoplasmic Reticulum Contact Sites (MERCS) are dynamic structures whose physiological interaction is vital to direct life and death of...
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Nanotechnology-Based Phytotherapeutics: Current Status and Challenges
Nanotechnology has the potential to overcome numerous shortcomings associated with conventional phytotherapeutics. Notable steps have been taken...
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D-limonene inhibits peritoneal adhesion formation in rats via anti-inflammatory, anti-angiogenic, and antioxidative effects
The aim of this research was to investigate the effects of d -limonene on decreasing post-operative adhesion in rats and to understand the mechanisms...
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Targeting PI3K/Akt in Cerebral Ischemia Reperfusion Injury Alleviation: From Signaling Networks to Targeted Therapy
Ischemia/reperfusion (I/R) injury is a pathological event that results in reperfusion due to low blood flow to an organ. Cerebral ischemia is a...
