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Effect of cachexia on bone turnover in cancer patients: a case-control study
BackgroundIncreased bone turnover is frequently observed in advanced cancer and predominantly related to bone metastases or therapy. Cachexia...
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An Overview of Bone Toxicology
The skeleton is an active and dynamic tissue that interacts with other complex systems such as the endocrine, nervous, and immune systems. During the...
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Centenarian longevity had inverse relationships with nutritional status and abdominal obesity and positive relationships with sex hormones and bone turnover in the oldest females
ObjectiveThe number of older people is estimated to increase from 524 million in 2010 to 1.5 billion in 2050. The factors and models of human...
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Bone Tumors: An Overview
Bone tumors account for less than 1% of all tumors. Most patients come with a history of progressive pain. Age and location of tumors are important...
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Enhanced molecular release from elderly bone samples using collagenase I: insights into fatty acid metabolism alterations
BackgroundBone is a metabolically active tissue containing different cell types acting as endocrine targets and effectors. Further, bone is a dynamic...
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Current knowledge of bone-derived factor osteocalcin: its role in the management and treatment of diabetes mellitus, osteoporosis, osteopetrosis and inflammatory joint diseases
Osteocalcin (OC) is the most abundant non-collagenous and osteoblast-secreted protein in bone. It consists of two forms such as carboxylated OC (cOC)...
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Extracellular Vesicles in Bone Remodeling and Osteoporosis
Osteoporosis is a systemic disorder characterized by bone mass loss, leading to fractures due to weak and brittle bones. The bone tissue...
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Markers of bone metabolism and overall survival in men with bone-metastatic hormone sensitive prostate cancer (HSPC): A subset analysis of SWOG S1216, a phase III trial of androgen deprivation with or without orteronel
BackgroundCirculating biomarkers of bone metabolism are significantly associated with overall survival (OS) in men with advanced prostate cancer. In...
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Long-term second-generation antipsychotics decreases bone formation and resorption in male patients with schizophrenia
RationalePatients with schizophrenia with second-generation antipsychotics (SGAs) treatment have shown an increased risk of bone fragility and...
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Flotillin-1 palmitoylation turnover by APT-1 and ZDHHC-19 promotes cervical cancer progression by suppressing IGF-1 receptor desensitization and proteostasis
We have shown that insulin-like growth factor-1 (IGF-1) induces palmitoylation turnover of Flotillin-1 (Flot-1) in the plasma membrane (PM) for cell...
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Homocysteine and Bone Health
Homocysteine is a sulfur-containing intermediary amino acid synthesized during methionine metabolism. Homocysteine has a significant role in the...
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Stable Isotope Tracer Methods for the Measure of Skeletal Muscle Protein Turnover
In this chapter, we will discuss two approaches to measure protein metabolism using stable isotope tracers and the advantages and disadvantages of...
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Autophagic Control of Stem Cells Differentiation into Osteogenic Lineage—Implications in Bone Disorders
AutophagyAutophagy is a degradative metabolic process involved in sustaining the cellular homeostasis by regulating the turnover of cytosolic...
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Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial
Preclinical evidence demonstrates that senescent cells accumulate with aging and that senolytics delay multiple age-related morbidities, including...
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Microstructural fatigue fracture behavior of glycated cortical bone
AbstractThe current study aims to simulate fatigue microdamage accumulation in glycated cortical bone with increased advanced glycation end-products...
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Pyroptosis in bone loss
Pyroptosis could be responsible for the bone loss from bone metabolic diseases, leading to the negative impact on people's health and life. It has...
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Fibrosis and bone marrow: understanding causation and pathobiology
Bone marrow fibrosis represents an important structural change in the marrow that interferes with some of its normal functions. The aetiopathogenesis...
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Comparative effects of various running exercise modalities on femoral bone quality in rats
BackgroundIt is now well established that physical exercise is an effective preventive method to reduce and treat certain chronic diseases,...
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Portable x-ray fluorescence for bone lead measurement: Current approaches and future directions
Purpose of ReviewLegacy lead exposures persist as a widespread problem. Blood lead is traditionally used for lead exposure surveillance; however,...
