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Transporter Systems and Metabolism at the Blood–Brain Barrier and Blood–CSF Barrier
Neurodegenerative disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD), are a leading cause of...
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Choroid plexus enlargement in amyotrophic lateral sclerosis patients and its correlation with clinical disability and blood-CSF barrier permeability
BackgroundUsing in vivo neuroimaging techniques, growing evidence has demonstrated that the choroid plexus (CP) volume is enlarged in patients with...
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Changes in CSF sPDGFRβ level and their association with blood–brain barrier breakdown in Alzheimer’s disease with or without small cerebrovascular lesions
BackgroundCSF-soluble platelet-derived growth factor receptor beta (sPDGFRβ) is closely associated with pericyte damage. However, the changes in CSF...
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Role of SPAK–NKCC1 signaling cascade in the choroid plexus blood–CSF barrier damage after stroke
BackgroundThe mechanisms underlying dysfunction of choroid plexus (ChP) blood–cerebrospinal fluid (CSF) barrier and lymphocyte invasion in...
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Evaluation of Blood-CSF Barrier Transport by Quantitative Real Time Fluorescence Microscopy
PurposeTransporters at the blood-cerebrospinal fluid (CSF) barrier (BCSFB) play active roles in removing drugs and toxins from the CSF. The goal of...
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Blood and CSF levels of brain-derived neurotrophic factor in patients with encephalopathy/encephalitis: a systematic review and meta-analysis
BackgroundBrain-derived neurotrophic factor (BDNF) is critical for enhancing the survival and growth of neurons and modulating the synaptic...
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Scavenger receptor CD36 governs recruitment of myeloid cells to the blood–CSF barrier after stroke in neonatal mice
BackgroundIschemic stroke induces the activation and recruitment of peripheral leukocytes to the injured brain. These cells can infiltrate the brain...
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Development of a multicellular in vitro model of the meningeal blood-CSF barrier to study Neisseria meningitidis infection
BackgroundBacterial meningitis is a life-threatening disease that occurs when pathogens such as Neisseria meningitidis cross the meningeal blood...
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Are CSF CXCL13 concentrations solely dependent on intrathecal production? A commentary on “Chemokine CXCL13 in serum, CSF, and blood–CSF barrier function”
Pilz et al. (Fluids Barriers CNS 17:7; 2020) investigated how CSF CXCL13 concentrations are influenced by CXCL13 serum concentrations and blood-CSF...
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Blood and CSF chemokines in Alzheimer’s disease and mild cognitive impairment: a systematic review and meta-analysis
ObjectiveChemokines, which are chemotactic inflammatory mediators involved in controlling the migration and residence of all immune cells, are...
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Visinin-like protein 1 levels in blood and CSF as emerging markers for Alzheimer’s and other neurodegenerative diseases
BackgroundVisinin-like protein 1 (VILIP-1) belongs to the group of emerging biomarkers with the potential to support the early diagnosis of...
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Functional Evaluation of P-gp and Bcrp at the Murine Blood-Cerebrospinal Fluid Barrier
PurposeThe brain is protected from circulating metabolites and xenobiotics by the blood–brain barrier (BBB) and the blood-cerebrospinal fluid (CSF)...
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Interactions of brain, blood, and CSF: a novel mathematical model of cerebral edema
BackgroundPrevious models of intracranial pressure (ICP) dynamics have not included flow of cerebral interstitial fluid (ISF) and changes in...
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Active Uptake of Oxycodone at Both the Blood-Cerebrospinal Fluid Barrier and The Blood-Brain Barrier without Sex Differences: A Rat Microdialysis Study
BackgroundOxycodone active uptake across the blood-brain barrier (BBB) is associated with the putative proton-coupled organic cation (H + /OC)...
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Blood-spinal cord barrier disruption in degenerative cervical myelopathy
Degenerative cervical myelopathy (DCM) is the most prevalent cause of spinal cord dysfunction in the aging population. Significant neurological...
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Elevated blood and cerebrospinal fluid biomarkers of microglial activation and blood‒brain barrier disruption in anti-NMDA receptor encephalitis
BackgroundAnti-NMDA receptor (NMDAR) encephalitis is an autoimmune disease characterized by complex neuropsychiatric syndrome and cerebrospinal fluid...
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Global alterations to the choroid plexus blood-CSF barrier in amyotrophic lateral sclerosis
The choroid plexus (CP) is a highly vascularized structure located in the ventricles that forms the blood-CSF barrier (BCSFB) and separates the blood...
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Population pharmacokinetic modeling of CSF to blood clearance: prospective tracer study of 161 patients under work-up for CSF disorders
BackgroundQuantitative measurements of cerebrospinal fluid to blood clearance has previously not been established for neurological diseases....
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Blood-Brain Barrier
While Edwin Goldmann is recognized as the first to provide substantial evidence of a blood-brain barrier (BBB) in 1909 and 1913, the actual term was...