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Critical Analysis of cGMP Large-Scale Expansion Process in Bioreactors of Human Induced Pluripotent Stem Cells in the Framework of Quality by Design
Human induced pluripotent stem cells (hiPSCs) are manufactured as advanced therapy medicinal products for tissue replacement applications. With this...
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Macroporous Cryogel-Based Systems for Water Treatment Applications and Safety: Nanocomposite-Based Cryogels and Bacteria-Based Bioreactors
Providing clean water to everyone is one of the current global challenges highlighted by the United Nations. Continuous industrial development,...
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Bioreactors
This chapter will introduce students to different types of bioreactors that help to culture 3D tissue-engineered constructs, providing cell growth in...
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Cows as Bioreactors for the Production of Nutritionally and Biomedically Significant Proteins
Dairy and beef cattle make a vital contribution to global nutritionNutrition, and since their domestication, they have been continuously exposed to...
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Large-Scale Culture of Mammalian Cells for Various Industrial Purposes
There is the widespread use of large-scale mammalian cell culture in biotechnological and pharmaceutical industries for various purposes. Select...
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Process Design for Human Mesenchymal Stem Cell Products in Stirred-Tank Bioreactors
Mesenchymal stem cells (MSCs) and their extracellular vesicles (EVs) are gaining importance as so-called advanced therapy medicinal products....
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Comparison of in Vascular Bioreactors and In Vivo Models of Degradation and Cellular Response of Mg–Zn–Mn Stents
Traditional in vitro evaluation criteria of magnesium (Mg)-based stents cannot reflect the degradation process in vivo , due to the interdependence...
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Viral Vector Upstream Processing and Clarification
The increasing number of gene therapy drugs entering the clinic targeting large population and/or large dosage diseases has forced gene therapy...
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Upstream Processing of Viral Therapeutics: From Host Cell Expansion to Virus Production
Viral vectors have emerged as a promising approach to treat genetic diseases and cancers, marking the start of a new era in the pharmaceutical...
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Bioreactor-Based Tissue Models as an Alternative Approach in Cancer Research
Integration of new technologies in cancer research in medicine provides an opportunity to do more comprehensive studies on more specified areas. One...
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Biofilm colonization and succession in a full-scale partial nitritation-anammox moving bed biofilm reactor
BackgroundPartial nitritation-anammox (PNA) is a biological nitrogen removal process commonly used in wastewater treatment plants for the treatment...
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A high-density microfluidic bioreactor for the automated manufacturing of CAR T cells
The manufacturing of autologous chimaeric antigen receptor (CAR) T cells largely relies either on fed-batch and manual processes that often lack...
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Mammalian Cell Culture in Three Dimensions: Basic Guidelines
Mammalian cell culture has technologically advanced from being conducted in two- to three-dimensional culture vessels (2D and 3D, respectively). The...
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Ecological interactions and the underlying mechanism of anammox and denitrification across the anammox enrichment with eutrophic lake sediments
BackgroundIncreasing attention has recently been devoted to the anaerobic ammonium oxidation (anammox) in eutrophic lakes due to its potential key...
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Machine learning-assisted identification of bioindicators predicts medium-chain carboxylate production performance of an anaerobic mixed culture
BackgroundThe ability to quantitatively predict ecophysiological functions of microbial communities provides an important step to engineer microbiota...
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Shear bioreactors stimulating chondrocyte regeneration, a systematic review
It is commonly accepted that the mechanical stimuli are important factors in the maintenance of normal structure and function of the articular...
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Use of Genome Editing Techniques to Produce Transgenic Farm Animals
Recombinant proteins are essential for the treatment and diagnosis of clinical human ailments. The availability and biological activity of...
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A Millifluidic Chamber for Controlled Shear Stress Testing: Application to Microbial Cultures
In vitro platforms such as bioreactors and microfluidic devices are commonly designed to engineer tissue models as well as to replicate the crosstalk...
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Microbial community regulation and performance enhancement in gas biofilters by interrupting bacterial communication
BackgroundControlling excess biomass accumulation and clogging is important for maintaining the performance of gas biofilters and reducing energy...
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Fungal Polysaccharide Production for Dermatological Purposes
Bioactive polysaccharides such as β-glucans are important structural component of cell wall in practically all fungi. To obtain these substances is...