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Exploration of Abiraterone acetate loaded Nanostructured lipid carriers for bioavailability improvement and circumvention of fast-fed variability
Abiraterone acetate (ABA), a biopharmaceutical class IV drug suffers from solubility and permeability pitfalls resulting in limited oral...
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Processability and Oral Bioavailability Improvement of Itraconazole by Particle Engineering Technique
The current study aimed to improve the processability and oral bioavailability of itraconazole (ITZ) via spherical agglomeration. ITZ-spherical...
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Phospholipid Complexation for Bioavailability Improvement of Albendazole: Preparation, Characterization and In Vivo Evaluation
The current study aimed to improve the poor solubility of albendazole (ABZ) by means of phospholipid complexation, hence to improve its oral...
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Research progress on pharmacological effects and bioavailability of berberine
Berberine (BBR), a benzylisoquinoline alkaloid obtained from natural medicines such as coptidis rhizoma , has a wide range of pharmacological...
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Challenges and Strategies for Bioavailability of Curcumin
Phytochemicals have been highlighted in several sectors of industry due to their different biological activities. In fact, the curcumin is a...
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Enhanced Oral Bioavailability of Isoformononetin Through Nanoemulsion: Development, Optimization, and Characterization
BackgroundIsoformononetin (IFN) is a methoxyl derivative of daidzein and has been stated as a potent osteogenic isoflavone. However, IFN has low oral...
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Improvement in Bioavailability and Pharmacokinetic Characteristics of Efavirenz with Booster Dose of Ritonavir in PEGylated PAMAM G4 Dendrimers
Efavirenz (EFV) with a booster dose of ritonavir (RTV) (EFV-RTV) inhibits the metabolism of EFV and improves its bioavailability. However, inadequate...
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Novel rivaroxaban-loaded microsphere systems with different surface microstructure for enhanced oral bioavailability
This study compares rivaroxaban-loaded polymeric microsphere systems with three types of surface microstructure. Three types of polymeric...
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Pharmacological properties of mangiferin: bioavailability, mechanisms of action and clinical perspectives
This review aims to provide an in-depth analysis of the pharmacological properties of mangiferin, focusing primarily on its bioavailability and...
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Development of a self-microemulsifying drug delivery system using a Dunnione to enhance bioavailability
PurposeThe purpose of this study was to enhance the solubility and oral bioavailability of Dunnione (DUN) using a self-microemulsifying drug delivery...
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PEGylated Erlotinib HCl Injectable Nanoformulation for Improved Bioavailability
The present study was undertaken to synthesize PEGylated monomethoxy poly (ethylene glycol)-poly (ε-Caprolactone) (mPEG-PCL) block copolymer and...
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Water in nigella oil microemulsion for enhanced oral bioavailability of linagliptin
Linagliptin is hydrophilic antidiabetic with poor oral bioavailability due to poor permeability and pre-systemic metabolism. The objective was to...
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Response surface optimization of a cardioprotective compound through pharmacosomal drug delivery system: in vivo bioavailability and cardioprotective activity potential
Vanillic acid (VA) is a phenolic compound with potential antioxidant activity, which improves ischemia-induced myocardial degeneration, by reducing...
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Clinical trials on curcumin in relation to its bioavailability and effect on malignant diseases: critical analysis
Curcumin is an ingredient of the root Curcuma longa , which is responsible for the characteristic yellow color of curcuma. Curcumin is said to have...
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Enhanced Oral Bioavailability of Progesterone in Bilosome Formulation: Fabrication, Statistical Optimization, and Pharmacokinetic Study
Progesterone, a female sex steroid hormone, is highly lipophilic, leading to poor oral bioavailability. This study aimed to develop a progesterone...
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Study on the Correlation Between Nimodipine (BCS Class II) Solubility, Dissolution Improvement, and Brain Tissue Concentration Through Cocrystallization
BackgroundCocrystallization by solvent evaporation was used to enhance the dissolution, physicochemical properties, and bioavailability of nimodipine...
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Revitalizing allicin for cancer therapy: advances in formulation strategies to enhance bioavailability, stability, and clinical efficacy
The main objective of this review is to highlight the therapeutic potential of allicin, a defense molecule in garlic known for its diverse health...
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Incorporating sodium deoxycholate endorsed the buccal administration of avanafil to heighten the bioavailability and duration of action
The highly effective phosphodiesterase type 5 inhibitor (avanafil; AVA) is routinely prescribed to treat erectile dysfunction. The drug has poor oral...
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Simple preparation and greatly improved oral bioavailability: The supersaturated drug delivery system of quercetin based on PVP K30
Quercetin, as a representative flavonoid, is widely present in daily diet and has been developed as a dietary supplement due to its beneficial...
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A Quality by Design Approach for Develo** SNEDDS Loaded with Vemurafenib for Enhanced Oral Bioavailability
Vemurafenib (VMF) is a practically insoluble (< 0.1 μg/mL) and least bioavailable (1%) drug. To enhance its oral bioavailability and solubility, we...
