Search
Search Results
-
Cell-Free DNA in Plasma Reveals Genomic Similarity Between Biliary Tract Inflammatory Lesion and Biliary Tract Cancer
Similar clinical manifestations and imaging features between biliary tract inflammatory lesion (BTI) and biliary tract cancer (BTC) pose significant...
-
Combination effects of amino acid transporter LAT1 inhibitor nanvuranlat and cytotoxic anticancer drug gemcitabine on pancreatic and biliary tract cancer cells
BackgroundCytotoxic anticancer drugs widely used in cancer chemotherapy have some limitations, such as the development of side effects and drug...
-
Transgelin-2, a novel cancer stem cell-related biomarker, is a diagnostic and therapeutic target for biliary tract cancer
BackgroundBiliary tract cancer (BTC) is a relatively rare but aggressive gastrointestinal cancer with a high mortality rate. Cancer stem cell (CSC)...
-
Sintilimab plus nab-paclitaxel as second-line treatment for advanced biliary tract cancer: study protocol for an investigator-initiated phase 2 trial (NapaSinti trial)
BackgroundBiliary tract cancer (BTC) is a relatively rare but highly aggressive malignancy. However, there is currently no satisfactory second-line...
-
Epidemiologic patterns of biliary tract cancer in the United States: 2001–2015
BackgroundBiliary tract cancer (BTC) includes intrahepatic cholangiocarcinoma (ICC), extrahepatic cholangiocarcinoma, gallbladder cancer, and ampulla...
-
Associations between cigarette smoking and biliary tract cancer by anatomic subsite and sex: a prospective cohort study in Japan
PurposeBiliary tract cancer (BTC) has not been considered a tobacco-related cancer, largely because of inconclusive results from epidemiological...
-
Experimental Model of Biliary Tract Cancers: Subcutaneous Xenograft of Human Cell Lines in Immunodeficient Nude Mice
The ectopic xenograft mouse model of cancer is a commonly employed tool for in vivo investigations, particularly for studying cell tumorigenicity and...
-
Epidemiology of biliary tract-associated bloodstream infections and adequacy of empiric therapy: an Australian population-based study
PurposeAlthough the biliary tract is a common source of invasive infections, the epidemiology of cholangitis- and cholecystitis-associated...
-
Chemotherapy and targeted therapy for advanced biliary tract cancers: an umbrella review
BackgroundMalignant tumors of the biliary system are characterized by a high degree of malignancy and strong invasiveness, and they are usually...
-
Potential influence of the microbiome environment in patients with biliary tract cancer and implications for therapy
Biliary tract cancers, including intra- and extra-hepatic cholangiocarcinoma as well as gallbladder cancer, are associated with poor prognosis and...
-
Gut microbiota and metabolites signatures of clinical response in anti-PD-1/PD-L1 based immunotherapy of biliary tract cancer
BackgroundAccumulating evidence suggests that the gut microbiota and metabolites can modulate tumor responses to immunotherapy; however, limited data...
-
Detection and characterization of pancreatic and biliary tract cancers using cell-free DNA fragmentomics
BackgroundPlasma cell-free DNA (cfDNA) fragmentomics has demonstrated significant differentiation power between cancer patients and healthy...
-
Gallstones and risk of cancers of the liver, biliary tract and pancreas: a prospective study within two U.S. cohorts
BackgroundGallstones may result in inflammation, altered bile flow, and changes in metabolic hormone levels, thereby increasing cancer risk. However,...
-
Cost-effectiveness analysis of pembrolizumab in combination with chemotherapy compared with chemotherapy alone as first-line treatment for patients with advanced biliary tract cancer in China
ObjectiveThe objective of this study is to evaluate the cost-effectiveness of adding pembrolizumab to the standard first-line therapy of advanced...
-
Mendelian randomization study of circulating lipids and biliary tract cancer among East Asians
BackgroundAssociations of High-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, total cholesterol (CHL), and...
-
Insights for clinical management from the real-life data of the centralized West of Scotland biliary cancer clinic
BackgroundWith the increasing of novel therapeutics for the treatment of Biliary Tract Cancers (BTC), and the need to assess their socio-economic...
-
Clinical usefulness and acceleratory effect of macrophage inhibitory cytokine-1 on biliary tract cancer: an experimental biomarker analysis
BackgroundBiliary tract cancer (BTC) has a poor prognosis; therefore, useful biomarkers and treatments are needed. Serum levels of macrophage...
-
Tumor Microenvironment and Immunotherapy in Advanced Biliary Tract Cancers
Intrahepatic, perihepatic, and hilar bile duct cancers are defined as cholangiocarcinoma (CCA). Cholangiocarcinomas constitute approximately 3% of...
-
HOXD8 hypermethylation as a fully sensitive and specific biomarker for biliary tract cancer detectable in tissue and bile samples
BackgroundBiliary tract cancers (BTC) are rare but highly aggressive tumours with poor prognosis, usually detected at advanced stages. Herein, we...
-
Randomised, Phase II study of selumetinib, an oral inhibitor of MEK, in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer
IntroductionCisplatin and gemcitabine (CisGem) are standard chemotherapy for advanced biliary tract cancer (BTC). The MEK inhibitor selumetinib...
