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Quantification of Compatibility Between Polymeric Excipients and Atenolol Using Principal Component Analysis and Hierarchical Cluster Analysis
An important challenge to overcome in the solid dosage forms technology is the selection of the most biopharmaceutically efficient polymeric...
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Comparative cardioprotective effects of carvedilol versus atenolol in a rat model of cardiorenal syndrome type 4
The incidence of chronic kidney disease is escalating; cardiorenal syndrome (CRS) type 4 is gaining a major health concern causing significant...
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Functional network analysis reveals potential repurposing of β-blocker atenolol for pancreatic cancer therapy
BackgroundThe survival rate of patients with pancreatic cancer is low; therefore, continuous discovery and development of novel pancreatic cancer...
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Single-cell Sequence Analysis Combined with Multiple Machine Learning to Identify Markers in Sepsis Patients: LILRA5
Sepsis is a disease with a very high mortality rate, mainly involving an immune-dysregulated response due to bacterial infection. Most studies are...
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Nebivolol in oral subacute treatment prevents cardiac post-ischemic dysfunction in rats, but hyperthyroidism reduces this protection: mechanisms involved
Nebivolol could prevent dysfunction in patients suffering myocardial ischemia. However, influence of hyperthyroidism is not known. Consequences and...
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β1- and β1/β2-adrenergic receptor antagonists block 6-nitrodopamine-induced contractions of the rat isolated epididymal vas deferens
6-Nitrodopamine (6-ND) is an endogenous modulator of the contractility in the rat isolated epididymal vas deferens (RIEVD) and considered to be the...
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The role of the peripheral and central adrenergic system in the construction of the subjective emotional experience of panic
RationaleAlthough the study of emotions can look back to over 100 years of research, it is unclear which information the brain uses to construct the...
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Co-prescription of metoprolol and CYP2D6-inhibiting antidepressants before and after implementation of an optimized drug interaction database in Norway
PurposeTo compare the co-prescription of metoprolol and potent CYP2D6-inhibiting antidepressants before and during a 10-year period after...
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Characterization of critical parameters using an air–liquid interface model with RPMI 2650 cells for permeability studies of small molecules
The field of nasal drug delivery gained enormously on interest over the past decade. Performing nasal in vivo studies is expensive and...
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Application of an Integrative Drug Safety Model for Detection of Adverse Drug Events Associated With Inhibition of Glutathione Peroxidase 1 in Chronic Obstructive Pulmonary Disease
BackgroundChronic Obstructive Pulmonary Disease is characterised by declining lung function and a greater oxidative stress burden due to reduced...
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Utilization patterns of cardiovascular medications in patients with diabetes mellitus; a retrospective cross-sectional study, 2013-17
BackgroundDiabetes Mellitus (DM) is a prominent health care issue worldwide. One of the most prevalent comorbidities of DM is cardiovascular disease...
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Influence of osmolality on gastrointestinal fluid volume and drug absorption: potential impact on oral salt supplementation
BackgroundThe syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is the most frequent cause of hyponatremia in patients with...
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Dissecting the role of cell signaling versus CD8+ T cell modulation in propranolol antitumor activity
AbstractPreclinical and early clinical mechanistic studies of antitumor activity from the beta-adrenergic receptor (β-AR) blocker propranolol have...
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Availability and affordability of cardiovascular medicines in a major city of Afghanistan in 2020
PurposeAffordable access to quality medicines is a critical target of global efforts to achieve universal health coverage. The aim of this study is...
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α1-adrenergic receptors accompanied by GATA4 expression are related to proarrhythmic conduction and automaticity in rat interatrial septum
The development of interatrial septum (IAS) is a complicated process, which continues during postnatal life. The hypertrophic signals in develo**...
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Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer’s disease
BackgroundGenome-wide association studies (GWAS) have identified numerous susceptibility loci for Alzheimer’s disease (AD). However, utilizing GWAS...
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The role of adrenergic and muscarinic receptors in stress-induced cardiac injury
Takotsubo syndrome (TS) is a rare but dangerous disease that can be fatal. The pathogenesis of TS is not well understood because there is no animal...
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Analysis of Non-linear Pharmacokinetics of P-Glycoprotein Substrates in a Microfluidic Device Using a Mathematical Model that Includes an Unstirred Water Layer (UWL) Compartment
PurposeThe purpose of this research is to analyze non-linear pharmacokinetics of P-glycoprotein (P-gp) substrates in a cell based assay of a...
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Three Days of Chronic Intermittent Hypoxia Induce β1-Adrenoceptor Dependent Increases in Left Ventricular Contractility
Sleep apnea is characterized by bouts of chronic intermittent hypoxia (CIH) that elicit sympathetic hyperactivity resulting in residual hypertension....